AR and YAP crosstalk: impacts on therapeutic strategies in prostate cancer

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 3, 2025

Prostate cancer ranks as one of the most common types affecting men worldwide, and its progression is shaped by a diverse array influencing factors. The AR signaling pathway plays pivotal role in pathogenesis prostate cancer. While existing anti-androgen treatments show initial efficacy, they ultimately do not succeed halting advancement to CRPC. Recent studies have identified alterations Hippo-YAP within cancer, highlighting intricate crosstalk with pathway. In this review, we examine interactions underlying mechanisms between YAP, key molecules these two pathways. regulates stability function YAP modulating transcription, translation, phosphorylation status, while exerts both promotional inhibitory regulatory effects on AR. Based findings, paper investigates their significant roles onset, progression, therapeutic resistance discusses clinical potential treatment.

Language: Английский

---

Silencing PPP2R1A inhibits the progression of gastric cancer cells

Journal of Cancer Research and Clinical Oncology, Journal Year: 2025, Volume and Issue: 151(4)

Published: April 18, 2025

Abstract Background Protein phosphatase 2 regulatory subunit A alpha ( PPP2R1A ) is the most common scaffold protein in PP2A complex and has known tumor-suppressive functions. However, its role gastric cancer (GC) still unclear. This study aims to elucidate potential of biological functions GC. Methods The mutation status expression levels GC were assessed through bioinformatics analysis, correlation between patient survival rates was examined, functional network analyzed. Stable AGS MGC803 cell lines set up for overexpressing silencing . effects on proliferation, migration, invasion, apoptosis CCK-8 assays, scratch Transwell flow cytometry. Results significantly elevated samples P < 0.001) not caused by mutations > 0.05). Patients with high have a poorer 5-year rate 0.001). Silencing inhibits invasion cells while promoting 0.01). In contrast, overexpression does significant impact these cellular Conclusion oncogenic properties progression GC, knocking down can inhibit tumor cells. suggests that may serve as prognostic marker therapeutic target

Language: Английский

---

Advances towards potential cancer therapeutics targeting Hippo signaling

Biochemical Society Transactions, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 6, 2024

Decades of research into the Hippo signaling pathway have greatly advanced our understanding its roles in organ growth, tissue regeneration, and tumorigenesis. The is frequently dysregulated human cancers recognized as a prominent cancer pathway. Hence, represents an ideal molecular target for therapies. This review will highlight recent advancements targeting treatment discuss potential opportunities developing new therapeutic modalities.

Language: Английский

---

Modeling human gastric cancers in immunocompetent mice

Cancer Biology and Medicine, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 18

Published: June 28, 2024

Gastric cancer (GC) is a major cause of cancer-related mortality worldwide. This determined by multiple (epi)genetic and environmental factors; can occur at distinct anatomic positions the stomach; displays high heterogeneity, with different cellular origins diverse histological molecular features. heterogeneity has hindered efforts to fully understand pathology GC develop efficient therapeutics. In past decade, great progress been made in study GC, particularly subtyping, investigation immune microenvironment, defining evolutionary path dynamics. Preclinical mouse models, immunocompetent models that mimic features human combination organoid culture clinical studies, have provided powerful tools for elucidating mechanisms underlying evasion, development novel therapeutic strategies. Herein, we first briefly introduce current challenges subsequently summarize emphasizing potential application genetically engineered antitumor immunity immunotherapy studies.

Language: Английский

---

STRIPAK, a fundamental signaling hub of eukaryotic development

Microbiology and Molecular Biology Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 11, 2024

The striatin-interacting phosphatase and kinase (STRIPAK) complex is involved in the regulation of many developmental processes eukaryotic microorganisms all animals, including humans. STRIPAK a component protein 2A (PP2A), highly conserved serine-threonine composed catalytic subunits (PP2Ac), scaffolding subunit (PP2AA) various substrate-directing B regulatory subunits. In particular, B''' called striatin has evoked major interest over last 20 years. Studies fungal systems have contributed substantially to our current knowledge about composition, assembly, cellular localization, as well its role autophagy morphology development. represents signaling hub with kinases thus integrates upstream downstream information from pathways. A profound understanding STRIPAK's fungi opens gateway multifarious functions carried out by higher eukaryotes, contribution malignant cell growth.

Language: Английский

---