Features of Highly Homologous T-Cell Receptor Repertoire in the Immune Response to Mutations in Immunogenic Epitopes DOI Open Access
Ksenia V. Zornikova, Dmitry V. Dianov, Nataliia O Ivanova

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12591 - 12591

Published: Nov. 23, 2024

CD8+ T-cell immunity, mediated through interactions between human leukocyte antigen (HLA) and the receptor (TCR), plays a pivotal role in conferring immune memory protection against viral infections. The emergence of SARS-CoV-2 variants presents significant challenge to existing population immunity. While numerous mutations have been associated with evasion from T cells, molecular effects most on epitope-specific TCR recognition remain largely unexplored, particularly for repertoires characterized by common TCRs. In this study, we investigated an HLA-A*24-restricted NYN epitope (Spike448-456) that elicits broad highly homologous cell responses COVID-19 patients. Eleven naturally occurring epitope, all which retained surface presentation HLA, were tested four transgenic Jurkat reporter lines. Our findings demonstrate that, exception L452R combined mutation L452Q + Y453F, these minimal impact avidity peptide-specific Additionally, observed similar responded differently mutant epitopes demonstrated cross-reactivity unrelated VYF (ORF3a112-120). results contradict idea limited diversity are insufficient provide emerging variants.

Language: Английский

T cell immune evasion by SARS-CoV-2 JN.1 escapees targeting two cytotoxic T cell epitope hotspots DOI

Jinmin Tian,

Bingli Shang,

Jianing Zhang

et al.

Nature Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Language: Английский

Citations

2
A Structural Voyage Toward the Landscape of Humoral and Cellular Immune Escapes of SARS‐CoV‐2 DOI Open Access

Jun Liu,

Yan Wu, George F. Gao

et al.

Immunological Reviews, Journal Year: 2025, Volume and Issue: 330(1)

Published: Feb. 5, 2025

ABSTRACT The genome‐based surveillance of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) in the past nearly 5 years since its emergence has refreshed our understanding virus evolution, especially on convergent co‐evolution with host. SARS‐CoV‐2 evolution been characterized by sets mutations that affect functional properties altering infectivity, virulence, transmissibility, and interactions host immunity. This poses a huge challenge to global prevention control measures based drug treatment vaccine application. As one key evasion strategies response immune profile human population, there are overwhelming amounts evidence for reduced antibody neutralization variants. Additionally, data also suggest levels CD4 + CD8 T‐cell responses against variants or sub‐variants decrease populations, although non‐negligible cross‐T‐cell maintained. Herein, from perspectives structural immunology, we outline characteristics mechanisms T cell SARS‐CoV variants/sub‐variants. molecular bases impact escaping interaction epitopes receptors adaptive immunity, is, major histocompatibility complex (MHC), receptor (TCR), summarized discussed, knowledge which will widen this pandemic‐threatening assist preparedness Pathogen X future.

Language: Английский

Citations

0
The molecular mechanisms of CD8+ T cell responses to SARS-CoV-2 infection mediated by TCR-pMHC interactions DOI Creative Commons

Shasha Deng,

Zhihao Xu,

Jing Hu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 10, 2024

Cytotoxic CD8

Language: Английский

Citations

1
Features of Highly Homologous T-Cell Receptor Repertoire in the Immune Response to Mutations in Immunogenic Epitopes DOI Open Access
Ksenia V. Zornikova, Dmitry V. Dianov, Nataliia O Ivanova

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12591 - 12591

Published: Nov. 23, 2024

CD8+ T-cell immunity, mediated through interactions between human leukocyte antigen (HLA) and the receptor (TCR), plays a pivotal role in conferring immune memory protection against viral infections. The emergence of SARS-CoV-2 variants presents significant challenge to existing population immunity. While numerous mutations have been associated with evasion from T cells, molecular effects most on epitope-specific TCR recognition remain largely unexplored, particularly for repertoires characterized by common TCRs. In this study, we investigated an HLA-A*24-restricted NYN epitope (Spike448-456) that elicits broad highly homologous cell responses COVID-19 patients. Eleven naturally occurring epitope, all which retained surface presentation HLA, were tested four transgenic Jurkat reporter lines. Our findings demonstrate that, exception L452R combined mutation L452Q + Y453F, these minimal impact avidity peptide-specific Additionally, observed similar responded differently mutant epitopes demonstrated cross-reactivity unrelated VYF (ORF3a112-120). results contradict idea limited diversity are insufficient provide emerging variants.

Language: Английский

Citations

1