The Pursuit of a Hydroxylation Switch Uncovers a Key Residue for Various Product Outcomes in the ent-Kaurene Synthase from Bradyrhizobium japonicum DOI
Youwei Li,

Yiting Mei,

Mark Schmidt-Dannert

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

A single residue switch leading to hydroxylation has been identified in ent-kaurene synthases (KSs) from plant gibberellin hormone biosynthesis. In this work, we a putative equivalent the bacterial BjKS gibberellin-producing Bradyrhizobium japonicum. Notably, serves as key that can be varied concert with surrounding network redirect product outcome, specificity of up 94%, providing mechanistic insight into not only but also (di)terpene more generally.

Language: Английский

The Pursuit of a Hydroxylation Switch Uncovers a Key Residue for Various Product Outcomes in the ent-Kaurene Synthase from Bradyrhizobium japonicum DOI
Youwei Li,

Yiting Mei,

Mark Schmidt-Dannert

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

A single residue switch leading to hydroxylation has been identified in ent-kaurene synthases (KSs) from plant gibberellin hormone biosynthesis. In this work, we a putative equivalent the bacterial BjKS gibberellin-producing Bradyrhizobium japonicum. Notably, serves as key that can be varied concert with surrounding network redirect product outcome, specificity of up 94%, providing mechanistic insight into not only but also (di)terpene more generally.

Language: Английский

Citations

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