Radiation symptoms resemble laminopathies and the physical underlying cause may sit at the lamin A C-terminus DOI Creative Commons

A Waldherr,

Anna Fogtman

Molecular Medicine, Journal Year: 2025, Volume and Issue: 31(1)

Published: Feb. 20, 2025

Ionizing radiation causes three divergent effects in the human body: On one side, tissue death (= deterministic effects) sets on, on other mutations and cancer growth stochastic can occur. In recent years, additional phenomenon of accelerated aging has come to light. following, we argue that these seemingly contradictory responses namely: (i) increased growth, (ii) ablation or (iii) senescence, share an underlying cause from damage at lamin A C-terminus. words, besides typically described genomic impact, propose destabilization pathway via oxidation nuclear envelope. We five concrete hypotheses draw a direct mechanistic model cellular oxidative stress, micronuclei clinical symptoms. conjunction with B compensation, might be able explain why dominate. If our holds true, novel target for radiotherapeutics radiooncology arises, rationale closer connect laminopathy radioprotection research.

Language: Английский

Radiation symptoms resemble laminopathies and the physical underlying cause may sit at the lamin A C-terminus DOI Creative Commons

A Waldherr,

Anna Fogtman

Molecular Medicine, Journal Year: 2025, Volume and Issue: 31(1)

Published: Feb. 20, 2025

Ionizing radiation causes three divergent effects in the human body: On one side, tissue death (= deterministic effects) sets on, on other mutations and cancer growth stochastic can occur. In recent years, additional phenomenon of accelerated aging has come to light. following, we argue that these seemingly contradictory responses namely: (i) increased growth, (ii) ablation or (iii) senescence, share an underlying cause from damage at lamin A C-terminus. words, besides typically described genomic impact, propose destabilization pathway via oxidation nuclear envelope. We five concrete hypotheses draw a direct mechanistic model cellular oxidative stress, micronuclei clinical symptoms. conjunction with B compensation, might be able explain why dominate. If our holds true, novel target for radiotherapeutics radiooncology arises, rationale closer connect laminopathy radioprotection research.

Language: Английский

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