Epigenetic regulation of macrophage function in kidney disease: New perspective on the interaction between epigenetics and immune modulation

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 183, P. 117842 - 117842

Published: Jan. 13, 2025

Language: Английский

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Emerging Mechanisms and Biomarkers Associated with T-Cells and B-Cells in Autoimmune Disorders

Clinical Reviews in Allergy & Immunology, Journal Year: 2025, Volume and Issue: 68(1)

Published: Feb. 11, 2025

Language: Английский

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Epigenetic regulation of transcription factors involved in NLRP3 inflammasome and NF-kB signaling pathways

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 19, 2025

The NLRP3 inflammasome and NF-κB signaling pathways play crucial roles in orchestrating inflammation immune defense.​ This review explores the intricate relationship between these epigenetic regulation, a field of growing importance understanding responses. Epigenetic modifications, including DNA methylation, histone non-coding RNAs (ncRNAs), significantly influence activity genes involved pathways, thereby modulating inflammatory provides comprehensive overview current research on how mechanisms interact with regulate pathways. It delves into advanced concepts such as RNA modifications 3D genome organization, their impact regulation. Furthermore, implications findings for developing novel therapeutic strategies targeting regulators diseases are discussed. By synthesizing recent advancements this rapidly evolving field, underscores critical role regulation highlights potential epigenetic-based therapies treating wide range conditions, autoimmune disorders cancer.

Language: Английский

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A phase 2 study of chidamide in combination with CAG and venetoclax-azacitidine in acute myeloid leukemia: Clinical safety, efficacy, and correlative analysis

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 151, P. 114268 - 114268

Published: Feb. 21, 2025

Language: Английский

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