X‐Ray‐Triggered CA IX Inhibition Nanoplatform Promotes Intratumoral Acidosis‐Induced Cancer Ferroptosis DOI

Yuanyuan You,

Wenxiao Jiang, Renhao Xu

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

Abstract Radiotherapy‐induced ferroptosis is accompanied by an adaptive response to the expression of tumor cell suppressor genes. Herein, a degradable and in situ generated silicomanganese composite system loaded with carbonic anhydrase (CA IX) inhibitor (4‐(2‐aminoethyl) benzenesulfonamide (ABS) constructed form DSiMn‐ABS nanosystem improve sensitivity hypoxic cells radiotherapy effect. The can be continuously degraded environment X‐rays, releasing Manganese dioxid （MnO 2 )and ABS; Thereby inhibiting activity CA IX, inducing acidification inside cells, regulating AMP‐activating protein kinase (AMPK)/Acetyl‐CoA carboxylase(ACC) axis increase ferroptosis, depleting glutathione (GSH) through MnO influencing peroxidase 4 (GPX4) activity, which further inhibits defense ultimately effectively improves therapeutic efficiency radiotherapy. Ultimately, inhibit growth. Therefore, this utilize double‐sensitized provide new ideas for

Language: Английский

Biological activation of Fenton reaction in polymeric nanoreactors driven by ferrocene-containing membranes: a microenvironment dependent study DOI Creative Commons

Alejandro González Vivancos,

Yang Zhou, Uwe Lappan

et al.

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Nanocatalytic medicine for treating cancer requires effective, versatile and novel tools approaches to significantly improve the therapeutic efficiency interactions of (non-)enzymatic reactions. However, it is necessary develop nanotechnologies capable selectively killing tumour cells without harming normal cells. Their characteristics should be adaption tumours' extra- intracellular environment being specifically active. To contribute this common goal, we propose use pH- redox-responsive ferrocene containing polymersomes (FcPsomes). This allows regulation their biological activities controlled production radicals

Language: Английский

Citations

0
Oxygen self-supplying perfluorocarbon-functionalized ferrocene nanosheets for enhanced cancer chemodynamic therapy DOI
Yaming Wang, Tan Ding, Fangying Zheng

et al.

Materials Today Chemistry, Journal Year: 2025, Volume and Issue: 45, P. 102681 - 102681

Published: April 1, 2025

Language: Английский

Citations

0
X‐Ray‐Triggered CA IX Inhibition Nanoplatform Promotes Intratumoral Acidosis‐Induced Cancer Ferroptosis DOI

Yuanyuan You,

Wenxiao Jiang, Renhao Xu

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

Abstract Radiotherapy‐induced ferroptosis is accompanied by an adaptive response to the expression of tumor cell suppressor genes. Herein, a degradable and in situ generated silicomanganese composite system loaded with carbonic anhydrase (CA IX) inhibitor (4‐(2‐aminoethyl) benzenesulfonamide (ABS) constructed form DSiMn‐ABS nanosystem improve sensitivity hypoxic cells radiotherapy effect. The can be continuously degraded environment X‐rays, releasing Manganese dioxid （MnO 2 )and ABS; Thereby inhibiting activity CA IX, inducing acidification inside cells, regulating AMP‐activating protein kinase (AMPK)/Acetyl‐CoA carboxylase(ACC) axis increase ferroptosis, depleting glutathione (GSH) through MnO influencing peroxidase 4 (GPX4) activity, which further inhibits defense ultimately effectively improves therapeutic efficiency radiotherapy. Ultimately, inhibit growth. Therefore, this utilize double‐sensitized provide new ideas for

Language: Английский

Citations

0