New immobilized lipases for synthesis of tyrosol esters in hydrophobic deep eutectic solvents DOI

Guobin Liang,

Yang Cheng,

Kang-Hong Wang

et al.

Biocatalysis and Biotransformation, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 9

Published: Dec. 24, 2024

As a new generation of water-immiscible solvents, hydrophobic deep eutectic solvents (HDESs) have shown great potential as green and sustainable reaction media for biocatalytic applications. Tyrosol is major phenolic compound present in olive oil wine with pharmacological benefits due to its strong antioxidant properties, application can be highly extended by increasing lipophilicity through esterification. In this study, two lipases, one from Aspergillus oryzae (AOL) another Pseudomonas fluorescens (PFL), were immobilized on inorganic salt crystals (i.e. @Cu3(PO4)2) metal-organic frameworks @HKUST-1). The structural features these four biocatalysts characterized their activity stability assayed. They successfully employed catalyze the esterification tyrosol produce esters HDESs excellent yields, which are comparable to, or even better than, results obtained using most commonly used commercial lipase Novozym 435 Novozymes). carboxylic acid-based provide not only medium but also an acylating agent enzymatic (trans)esterification reactions.

Language: Английский

A Comprehensive Review on Deep Eutectic Solvents: Their Current Status and Potential for Extracting Active Compounds from Adaptogenic Plants DOI Creative Commons
Małgorzata Stanisz, Beata Stanisz, Judyta Cielecka‐Piontek

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(19), P. 4767 - 4767

Published: Oct. 9, 2024

Deep eutectic solvents (DESs) have attracted attention from researchers as novel compounds for extracting active substances because of their negligible toxicity, polarity, and ability to be tailored depending on the experiment. In this review, we discuss deep a promising medium extraction adaptogenic compounds. comparison traditional methods, with use DESs is great alternative excessive usage harmful organic solvents. It can conducted in mild conditions, designed different precursors, enhancing versatility. Adaptogenic herbs long medicinal history, especially Eastern Asia. They exhibit unique properties through structures, including saponins, flavonoids, polysaccharides, alkaloids. Therefore, they demonstrate wide range pharmaceutical effects, such anti-inflammatory, antibacterial, anticancer abilities. Since ancient times, many been discovered are well known,

Language: Английский

Citations

4
The exploration of interaction between DES (1 TEAB: 3 EG) and molecular solvents by transfer properties DOI
Jie Wei,

Chunlin Tao,

Jingyuan He

et al.

Journal of Molecular Liquids, Journal Year: 2024, Volume and Issue: unknown, P. 126757 - 126757

Published: Dec. 1, 2024

Language: Английский

Citations

1
New immobilized lipases for synthesis of tyrosol esters in hydrophobic deep eutectic solvents DOI

Guobin Liang,

Yang Cheng,

Kang-Hong Wang

et al.

Biocatalysis and Biotransformation, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 9

Published: Dec. 24, 2024

As a new generation of water-immiscible solvents, hydrophobic deep eutectic solvents (HDESs) have shown great potential as green and sustainable reaction media for biocatalytic applications. Tyrosol is major phenolic compound present in olive oil wine with pharmacological benefits due to its strong antioxidant properties, application can be highly extended by increasing lipophilicity through esterification. In this study, two lipases, one from Aspergillus oryzae (AOL) another Pseudomonas fluorescens (PFL), were immobilized on inorganic salt crystals (i.e. @Cu3(PO4)2) metal-organic frameworks @HKUST-1). The structural features these four biocatalysts characterized their activity stability assayed. They successfully employed catalyze the esterification tyrosol produce esters HDESs excellent yields, which are comparable to, or even better than, results obtained using most commonly used commercial lipase Novozym 435 Novozymes). carboxylic acid-based provide not only medium but also an acylating agent enzymatic (trans)esterification reactions.

Language: Английский

Citations

0