Microbiome Integrity Enhances the Efficacy and Safety of Anticancer Drug

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 422 - 422

Published: Feb. 10, 2025

The intricate relationship between anticancer drugs and the gut microbiome influences cancer treatment outcomes. This review paper focuses on role of integrity in enhancing efficacy safety drug therapy, emphasizing pharmacokinetic interactions microbiota. It explores how disruptions to composition, or dysbiosis, can alter metabolism, immune responses, side effects. By examining mechanisms disruption caused by drugs, this highlights specific case studies like cyclophosphamide, 5-fluorouracil, irinotecan, their impact microbial diversity clinical also discusses microbiome-targeted strategies, including prebiotics, probiotics, postbiotics, fecal microbiota transplantation (FMT), as promising interventions enhance treatment. Furthermore, potential profiling personalizing therapy integrating these into practice is explored. Finally, proposes future research directions, developing novel biomarkers a deeper comprehension drug-microbiome interactions, respond current gaps knowledge improve patient outcomes care.

Language: Английский

Microbiota and Inflammatory Markers: A Review of Their Interplay, Clinical Implications, and Metabolic Disorders

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1773 - 1773

Published: Feb. 19, 2025

The human microbiota, a complex ecosystem of microorganisms, plays pivotal role in regulating host immunity and metabolism. This review investigates the interplay between microbiota inflammatory markers, emphasizing their impact on metabolic autoimmune disorders. Key biomarkers, such as C-reactive protein (CRP), interleukin-6 (IL-6), lipopolysaccharides (LPS), zonulin (ZO-1), netrin-1 (Ntn1), are discussed context intestinal barrier integrity chronic inflammation. Dysbiosis, characterized by alterations microbial composition function, directly modulates levels activity these exacerbating responses compromising epithelial barriers. disruption is further correlated with increased permeability inflammation, serving precursor to conditions like type 2 diabetes (T2D), obesity, non-alcoholic fatty liver disease. Additionally, this examines therapeutic strategies, including probiotics prebiotics, designed restore balance, mitigate enhance homeostasis. Emerging evidence positions microbiota-targeted interventions critical components advancement precision medicine, offering promising avenues for diagnosing treating

Language: Английский

Impact of Microencapsulation on Escherichia coli Transcriptome under Simulated Gastric Stress: Implications for Oral Fecal Microbiota Transplant Delivery

Food Hydrocolloids for Health, Journal Year: 2025, Volume and Issue: unknown, P. 100214 - 100214

Published: April 1, 2025

Language: Английский