Lupus,
Journal Year:
2023,
Volume and Issue:
32(14), P. 1686 - 1688
Published: Nov. 9, 2023
Cranial
neuropathy
is
a
rare
presentation
in
juvenile
(j)
SLE
and
being
multiple
even
rarer.
We
describe
here
an
adolescent
girl
presenting
with
polyneuritis
cranialis
(PNC)
as
initial
of
which
had
not
been
reported
before
literature.
She
presented
symptoms
suggestive
bilateral
abducent
hypoglossal
nerve
conduction
studies
showing
partial
axonal
left
facial
accessory
nerves,
6
weeks
after
common
cold.
The
condition
was
associated
any
other
neurological
or
systemic
manifestations
nor
features
Sjogren's
syndrome.
Her
responded
well
to
pulsed
methylprednisolone
therapy
plasma
exchange.
After
exclusion
the
causes
owing
positive
ANA
results
mild
proteinuria,
renal
biopsy
taken
revealed
histopathological
class
III
lupus
nephritis
for
mycophenolate
mofetil
started
at
1200
mg
per
m2.
Our
case
highlights
importance
considering
collagen
disorders
including
differential
diagnosis
children
PNC
order
allow
adequate
management
proper
follow-up.
Diagnostics,
Journal Year:
2024,
Volume and Issue:
14(11), P. 1186 - 1186
Published: June 5, 2024
Systemic
lupus
erythematosus
(SLE)
is
a
chronic
autoimmune
condition
that
can
seriously
impair
multiple
organs
including
the
nervous
system,
causing
neuropsychiatric
SLE
(NPSLE),
which
encompasses
broad
range
of
symptoms.
Pathogenesis
not
completely
understood
but
thought
to
involve
inflammatory
and
vascular
pathways.
This
comprehensive
review
discusses
complex
nature
heterogeneity
NPSLE
challenges
in
diagnosis
treatment
result
from
it.
Diagnosis
often
requires
multidisciplinary
approach
with
assessments,
laboratory
testing,
imaging,
neuropsychological
evaluations.
Current
treatments
focus
on
managing
symptoms
through
immunosuppressive
anti-thrombotic
therapies
tailored
or
specific
manifestations.
paper
emphasizes
necessity
for
interdisciplinary
approaches
further
research
enhance
diagnostic
accuracy
effectiveness.
It
also
highlights
importance
understanding
underlying
mechanisms
develop
more
targeted
therapies,
citing
need
high-quality
studies
novel
agents.
Molecular and Cellular Pediatrics,
Journal Year:
2023,
Volume and Issue:
10(1)
Published: Aug. 9, 2023
Systemic
lupus
erythematosus
(SLE)
is
a
rare
autoimmune/inflammatory
disease
with
significant
morbidity
and
mortality.
Approximately
15-20%
of
SLE
patients
develop
the
during
childhood
or
adolescence
(juvenile-onset
SLE/jSLE).
Patients
jSLE
exhibit
more
variable
severe
when
compared
to
disease-onset
adulthood.
Neuropsychiatric
(NP)
involvement
clinically
heterogenous
potentially
complication.
Published
reports
on
incidence
prevalence
NP-jSLE
are
scarce,
exact
pathophysiology
poorly
understood.This
manuscript
provides
review
existing
literature,
suggesting
NP
in
13.5-51%
patients.
Among
affecting
CNS,
we
propose
two
main
subgroups:
(i)
chronic
progressive,
predominantly
type
1
interferon-driven
form
that
responds
currently
used
treatments,
(ii)
an
acutely
aggressive
usually
presents
early
may
be
primarily
mediated
by
auto-reactive
effector
lymphocytes.
While
this
hypothesis
requires
tested
large
collaborative
international
cohort
studies,
it
offer
future
patient
stratification
individualised
care.
Clinical Case Reports,
Journal Year:
2025,
Volume and Issue:
13(4)
Published: March 27, 2025
ABSTRACT
This
case
report
presents
a
preadolescent
female
with
rare
presentation
of
lupus
as
isolated
chorea.
An
investigation
to
find
out
the
cause
unexplained
cytopenia
raised
inflammatory
markers
ultimately
led
diagnosis
neuropsychiatric
antiphospholipid
antibodies.
Lupus
should
always
be
included
in
differential
for
chorea
children.
Annals of Human Genetics,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 2, 2025
ABSTRACT
Introduction
Observational
studies
have
indicated
an
association
between
systemic
lupus
erythematosus
(SLE)
and
stroke.
However,
the
genetic
causality
of
this
remains
incompletely
understood.
This
study
utilizes
Mendelian
randomization
(MR)
to
investigate
potential
causal
relationship
SLE
risk
Methods
We
utilized
summary‐level
statistics
data
from
largest
genome‐wide
(GWASs)
on
The
primary
MR
analysis
was
conducted
using
inverse
variance
weighted
(IVW)
method,
with
supplementary
analyses
performed
MR‐Egger
median
(WM)
methods.
Sensitivity
heterogeneity
were
additionally
ensure
robustness
results.
Results
IVW
a
increased
any
ischemic
stroke
(odds
ratio
[OR]
=
1.039,
95%
confidence
interval
[CI]:
1.014–1.066,
p
0.002).
no
significant
observed
large
artery
(OR:
1.024,
CI:
0.975–1.076,
0.326),
cardioembolic
1.014,
0.948–1.085,
0.667),
small
vessel
0.983,
0.942–1.026,
0.458),
or
intracerebral
hemorrhage
0.992,
0.934–1.054,
0.804).
Conclusion
provides
evidence
supporting
These
findings
underscore
significance
active
monitoring
prevention
mitigate
cerebrovascular
comorbidities
in
patients.
Given
existence
ethnic‐specific
genomic
heterogeneity,
caution
is
warranted
interpreting
these
Child Neuropsychology,
Journal Year:
2023,
Volume and Issue:
30(5), P. 818 - 846
Published: Oct. 30, 2023
Cognitive
dysfunction
(CD)
is
a
neurologic
complication
of
pediatric
systemic
lupus
erythematosus
(SLE)
that
remains
poorly
understood
and
understudied,
despite
the
potential
negative
effects
CD
on
long-term
socioeconomic
status
quality
life.
Data
regarding
prevalence
risk
factors
for
in
SLE
as
well
optimal
screening,
treatment,
outcomes
are
lacking.
In
this
review,
we
present
current
knowledge
with
focus
application
to
clinical
practice.
We
discuss
challenges
diagnosis,
screening
methods,
impacts,
interventions
complication.
Finally,
remaining
gaps
our
SLE,
avenues
future
research
efforts.
Rheumatology Science and Practice,
Journal Year:
2024,
Volume and Issue:
62(1), P. 109 - 117
Published: March 1, 2024
The
prevalence
of
concomitant
mental
disorders
in
children
with
rheumatic
diseases
is
notably
higher
than
the
overall
population.
However,
psychiatric
comorbidity
pediatric
rheumatology
remains
poorly
understood,
whereas
approaches
to
therapy
are
not
clearly
defined.
review
article
considers
currently
available
data
on
prevaling
patients
juvenile
idiopathic
arthritis,
juvenile-onset
systemic
lupus
erythematosus
and
primary
fibromyalgia.
provides
efficacy
safety
studies
psychotherapy
psychopharmacotherapy.
It
also
discusses
application
prospects
biological
disease-modifying
antirheumatic
drugs
for
treatment
comorbid
depression
diseases.
Lupus,
Journal Year:
2024,
Volume and Issue:
33(7), P. 759 - 761
Published: April 12, 2024
Idiopathic
intracranial
hypertension
(IIH)
is
a
diagnosis
of
exclusion
characterized
by
features
raised
pressure
(ICP)
in
the
absence
brain
parenchymal
lesion,
vascular
malformations,
hydrocephalus,
or
central
nervous
system
(CNS)
infection.
Commonly
used
other
terms
for
this
entity
include
benign
(BIH)
pseudotumor
cerebri.
Few
case
reports
systemic
lupus
erythematosus
(SLE)
presenting
as
IIH
are
available
literature.
We
report
12-year-old
girl
presented
with
chronic
holocranial
headache
and
occasional
episodes
projectile
vomiting
last
6
months
then
developed
blurring
vision
month.
She
fulfilled
criteria
IIH.
Subsequent
evaluation
revealed
SLE.
The
occurrence
SLE
not
coincidental
reported
1%-5.4%
patients
Though
corticosteroids
have
been
widely
IIH,
underlying
warranted
administering
subsequent
complete
resolution
Pediatricians,
neurologists,
intensivists,
ophthalmologists
should
consider
differential
children
