Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(26)
Published: Feb. 23, 2024
Abstract
Antibacterial
photocatalytic
therapy
(APCT)
is
one
of
the
most
promising
non‐antibiotic
treatment
strategies
for
biofilm‐infected
wounds
and
inflammation
caused
by
drug‐resistant
bacteria.
However,
it
still
faces
issues
such
as
inadequate
single
antibacterial
capacity
lack
antioxidant
capacity.
In
this
study,
a
Z‐scheme
heterojunction
(Bi
2
S
3‐X
@PDA)
designed
using
polydopamine
(PDA)
shell
firmly
anchored
to
surface
sulfur
vacancy‐rich
bismuth
sulfide
nanorods
NRs).
Under
near‐infrared
light
hydrogen
peroxide,
Bi
@PDA
significantly
improves
efficiency
reactive
oxygen
species
generation
shows
nearly
100%
broad‐spectrum
effect
against
multiple
bacterial
strains
biofilms
in
vitro.
Interestingly,
activity
PDA
remarkably
downregulates
expression
pro‐inflammatory
factors
promotes
macrophage
reprogramming
toward
proregenerative
M2
phenotype.
mouse
wound
model
methicillin‐resistant
Staphylococcus
aureus
biofilm
infection,
effectively
eliminates
through
APCT/mild
photothermal
therapy,
while
reducing
normal
tissues
regulating
immune
microenvironment,
thereby
promoting
rapid
healing.
Overall,
light‐controlled
strategy,
which
provides
both
anti‐inflammatory
functions,
reliable
tool
combating
infection
