Chemoselective reductive coupling of α, β-unsaturated esters and nitroarenes for sustainable synthesis of β-amino acid esters by a hierarchically porous cobalt nanocatalyst DOI
Huanhuan Jia,

Junwei Xi,

Rong Xie

et al.

Journal of Catalysis, Journal Year: 2023, Volume and Issue: 429, P. 115239 - 115239

Published: Dec. 5, 2023

Language: Английский

S‐Doping Regulated Iron Spin States in Fe−N−C Single‐Atom Material for Enhanced Peroxidase‐Mimicking Activity at Neutral pH DOI
Fuying Zhu,

Yueyi Yu,

Zhixuan Yu

et al.

Small, Journal Year: 2024, Volume and Issue: 20(33)

Published: March 31, 2024

Designing biomimetic nanomaterials with peroxidase (POD)-like activity at neutral pH remains a significant challenge. An S-doping strategy is developed to afford an iron single-atom nanomaterial (Fe

Language: Английский

Citations

9
Visible-light-mediated synthesis of polysubstituted pyrroles via CAr–I reduction triggered 1,5-hydrogen atom transfer process DOI
Junlei Wang,

Qinglin Xie,

Guocheng Gao

et al.

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(16), P. 4522 - 4528

Published: Jan. 1, 2024

A novel strategy for the construction of polysubstituted pyrroles has been developed through visible-light-induced single-electron reduction C Ar –I bonds and following 1,5-hydrogen atom transfer (HAT) process.

Language: Английский

Citations

6
Metal-Free Nitrogen-Doped Mesoporous Carbons for the Mild and Selective Synthesis of Pyrroles from Nitroarenes via Cascade Reaction DOI

Xiangzhu Yu,

Meng Miao,

Shuxiao Huo

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(13), P. 16363 - 16372

Published: March 19, 2024

The cascade synthesis of pyrroles from nitroarenes is an attractive alternative strategy. However, metal catalysts and relatively high temperatures cover the existing reported catalytic systems for this development nonmetallic heterogeneous one-pot pyrrole under mild conditions both worthwhile challenging. Herein, we describe exceptionally efficient method N-substituted by reductive coupling diketones over metal-free conditions. Nonmetallic NC-X with activity were prepared pyrolysis well-defined ligands via simple sacrificing hard template methods. Hydrazine hydrate, formic acid, molecular hydrogen can all be used as reducing agents in hydrogenation/Paal–Knorr reaction sequence to efficiently synthesize various pyrroles, including drugs bioactive molecules. system was featured good tolerance sensitive functional groups no side reactions such dehalogenation aromatics hydrogenation. Hammett correlation studies have shown that electron-donating substituents are beneficial pyrroles. results established outstanding performance catalyst mainly attributed contribution graphitic N well promotion effect mesoporous structure on reaction.

Language: Английский

Citations

4
Applying green chemistry principles to iron catalysis: mild and selective domino synthesis of pyrroles from nitroarenes DOI Creative Commons
Johannes Fessler, Kathrin Junge, Matthias Beller

et al.

Chemical Science, Journal Year: 2023, Volume and Issue: 14(41), P. 11374 - 11380

Published: Jan. 1, 2023

An efficient and general cascade synthesis of pyrroles from nitroarenes using an acid-tolerant homogeneous iron catalyst is presented. Initial (transfer) hydrogenation the commercially available iron-Tetraphos followed by acid catalysed Paal-Knorr condensation. Both formic molecular hydrogen can be used as green reductants in this process. Particularly, under transfer conditions, shows remarkable reactivity at low temperatures, high functional group tolerance excellent chemoselectivity transforming a wide variety substrates. Compared to classical heterogeneous catalysts, system presents complementing reactivity, showing none typical side reactions such dehalogenation, debenzylation, arene or olefin hydrogenation. It thereby enhances chemical toolbox terms orthogonal reactivity. The methodology was successfully applied late-stage modification multi-functional drug(-like) molecules well one-pot bioactive agent BM-635.

Language: Английский

Citations

10
Molybdenum‐Catalyzed Direct Synthesis of Pyrroles from Nitroarenes with Glycols as Reductants DOI Creative Commons
Sara Gómez‐Gil, Samuel Suárez‐Pantiga, M.R. Pedrosa

et al.

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 21, 2024

Abstract A molybdenum‐catalyzed synthesis of N ‐(hetero)aryl pyrroles directly from inexpensive and commonly available (hetero)nitroarenes via reduction with pinacol annulation 1,4‐dicarbonyls or cyclobutane‐1,2‐diols has been described. The process does not require an inert atmosphere tolerates the presence air water. This non‐noble catalytic system shows high chemoselectivity, allowing a diverse range potentially reducible functional groups such as alkynes, alkenes, halogens, cyano, carbonyls. Moreover, this strategy enables reuse waste byproduct reactant, facilitating formation challenging accessible used reducing agents.

Language: Английский

Citations

1
Gaseous toluene heterogeneous oxidative degradation by iron-based hypercrosslinked polymeric resin LXQ-10 DOI

Zhaohui Du,

Ying Yuan,

Changsong Zhou

et al.

Fuel, Journal Year: 2023, Volume and Issue: 344, P. 128080 - 128080

Published: March 20, 2023

Language: Английский

Citations

3
Theory study on catalytic hydrogenation of CO2 to formic acid over Si, N‐doped modified graphene quantum dots supported single atom Fe DOI
Fangfang Li, Xunchao Zhang, Lihua Kang

et al.

International Journal of Quantum Chemistry, Journal Year: 2024, Volume and Issue: 124(11)

Published: May 30, 2024

Abstract Exploring suitable catalysts to catalyze the chemical transformation of CO 2 molecules is essential reduce levels. In this article, catalyst models Fe‐C 4 , Fe‐N and Fe‐Si were constructed using density functional theory (DFT) calculations, reaction mechanisms hydrogenation over these three calculated analyzed. The results showed that doping N atoms lowered energy barrier second step compared with catalyst, while Si changed electron distribution on surface formed new adsorption sites. And had a stronger ability activate as well catalytic performance catalysts, which was mainly attributed synergistic effect between doped Fe metal atom.

Language: Английский

Citations

0
Chemoselective Reductive Coupling of Α, Β-Unsaturated Esters and Nitroarenes for Sustainable Synthesis of Β-Amino Acid Esters by a Hierarchically Porous Cobalt Nanocatalyst DOI
Min Zhang, Huanhuan Jia,

Junwei Xi

et al.

Published: Jan. 1, 2023

Reductive coupling of two unsaturated substances for the construction functional molecules remains a significant challenge due to difficulty in controlling chemoselective reduction. Here, by developing cobalt and nitrogen co-doped hierarchically porous carbon material (Co/N-HPNC) deriving from homomorphic Zr-based metal-organic framework (MOF), we describe, first time, its application as bifunctional catalyst direct access β-amino acid esters via reductive hydroamination α, β-unsaturated with cheap air-stable nitroarenes. The structure-performance relationship reveals that N-dopants benefit adsorption nitroarenes protons, active species run transfer hydrogenation nitroarenes, such synergisitc effect results formation desired products. developed catalytic transformation proceeds good substrate functionality tolerance, use easily accessible reusable base metal catalyst, operational simplicity, high step atom efficiency, easy applicability further fabrication molecules, which offers sustainable platform synthesis valuable products bulk raw materials.

Language: Английский

Citations

0
Chemoselective reductive coupling of α, β-unsaturated esters and nitroarenes for sustainable synthesis of β-amino acid esters by a hierarchically porous cobalt nanocatalyst DOI
Huanhuan Jia,

Junwei Xi,

Rong Xie

et al.

Journal of Catalysis, Journal Year: 2023, Volume and Issue: 429, P. 115239 - 115239

Published: Dec. 5, 2023

Language: Английский

Citations

0