Accounts of Chemical Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

ConspectusDiazocarbonyl compounds have become essential tools in organic synthesis, due to their ability situ generate reactive carbenes and be inserted a variety of otherwise stable bonds, such as C-H, C-C, H-O, so on. However, soluble metal salt or complex catalyst is generally required selectively activate couple the carbene, metals employed far are expensive (Rh, Au, Ag, Cu) often unrecoverable. It noteworthy that price ligands can make cheaper (i.e., other ligand-free noble catalysts. In realm modern sustainable chemistry, most these methodologies now unacceptable must adapted, simple strategies for include carbene photoactivation use recoverable solid Unfortunately, despite research field insertion reactions has extended more than 50 years, examples with catalysts still minor, efficient only been reported last two decades.This Account shows journey faced by our group eight years find challenging reactions, employing diazocarbonyl precursors. We will contextualize results those previous The discovery 2017 quasi-linear Pd4 cluster stabilized within metal-organic framework (MOF) was able catalyze Büchner spurred design supported clusters reactions. Pd4-MOF could reused 20 times batch implemented flow process. Following this, catalytic solids, including Au Ag metals, not same MOF but also on oxides zeolites supports, showed good activity were reusable.Our temporarily finishes 2024 when "blank" experiments dealuminated zeolite surprisingly revealed this acid, without any metal, easily activates compound catalyzes thus providing cheap, commercially available, reusable Overall, rapid progress solid-catalyzed activation, formation, achieved during moving from difficult prepare based acid zeolites, pointing confined Brønsted acids study near future.

Language: Английский