Factors influencing anxiety and depression in advanced hepatocellular carcinoma patients and their impact on quality of life

World Journal of Psychiatry, Journal Year: 2025, Volume and Issue: 15(5)

Published: April 30, 2025

BACKGROUND Patients with middle and advanced hepatocellular carcinoma (HCC) frequently experience significant anxiety depression, severely affecting their quality of life. AIM To examine the depression status patients HCC, influencing factors, correlation between these psychological factors METHODS We collected baseline data from 100 assessing levels using Hamilton Anxiety Rating Scale (HAMA) Depression (HAMD). Quality life was evaluated Functional Assessment Cancer Therapy-Hepatobiliary Questionnaire. Multivariate logistic regression analyzed clinical psychosocial while Pearson assessed relationships among HAMA, HAMD, Questionnaire scores. RESULTS Results indicated that 64% exhibited 65% showed symptoms. Key included Barcelona Clinic Liver C stage, multiple tumors, social support, prior treatments (such as liver resection transcatheter arterial chemoembolization/hepatic artery infusion chemotherapy), well HAMA HAMD correlated negatively life, coefficients -0.671 -0.575 for respectively. CONCLUSION are prevalent impacting This underscores need health considerations in cancer treatment establishing interventions is essential.

Language: Английский

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Comparative efficacy of interventional therapy with or without targeted immunotherapy in Child-Pugh B hepatocellular carcinoma patients: a single-center, retrospective study

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: May 1, 2025

Background Current large clinical trials mainly focus on Child-Pugh A (CP-A) stage hepatocellular carcinoma (HCC) patients, with limited data CP-B patients especially those classified as B8-9, whose treatment needs remain inadequately addressed. This study aims to evaluate the safety efficacy of interventional treatments, or without targeted-immunotherapy and characteristics HCC receiving. Methods single-center retrospective investigation incorporated 119 were stratified into two cohorts: therapy cohort (42) combined targeted immunotherapy (77). The data, overall survival (OS), progression-free (PFS), therapeutic both groups meticulously recorded comprehensively analyzed. Survival disparities statistically compared employing Kaplan-Meier analysis method log-rank test. Tumor remission was appraised in accordance RECIST 1.1 mRECIST criteria. Independent influencing factors discerned through multifactorial COX regression analysis. Subsequently, prediction models constructed generate column line graphs, profiles adverse events associated diverse modalities also evaluated. Results grade included, median (mOS) who received combination 21.4 months (vs 13.2, P=0.038) superior that therapy, (mPFS) 12.7 10.9 months, P=0.183) not significantly improved. OS group B7 24.6 11.9, P=0.006) intervention, while there no significant improvement B8-9. objective rate (ORR) higher than intervention (RECIST: 32.5% vs 11.9%, P = 0.014; mRECIST: 48.1% 23.8%, 0.010). Except for score progression (P 0.003), difference occurrence all-grade ≥grade 3 > 0.05). Conclusion Interventional can be a safe effective B setting controlled liver function impairment.

Language: Английский

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NRF1-Induced lncRNA DDX11-AS1 Contributes to the Progression of Hepatocellular Carcinoma via Activating CA9 Expression and the MEK/ERK Pathway

Journal of Hepatocellular Carcinoma, Journal Year: 2025, Volume and Issue: Volume 12, P. 891 - 908

Published: May 1, 2025

DDX11 antisense RNA 1 (DDX11-AS1) has been recognized for its strong correlation with hepatocellular carcinoma (HCC). Nevertheless, the exact biological functions and fundamental molecular processes of DDX11-AS1 in HCC require further in-depth investigation. A comprehensive bioinformatics analysis was carried out to explore expression clinical implication utilizing TCGA data. qRT-PCR employed validate tissues/cell lines. fluorescence situ hybridization (RNA-FISH) used observe subcellular localization cells. Loss-of-function experiments, both vitro vivo, were executed elucidate HCC. sequencing (RNA-seq) identify genes signaling pathways potentially regulated by DDX11-AS1. Rescue experiments conducted that carbonic anhydrase IX (CA9) mediates promoting progression. The influence nuclear respiratory factor (NRF1) on transcription investigated through dual-luciferase reporter assays ChIP-qPCR. increased is positively associated several aggressive characteristics (pathologic T stage, histologic grade, AFP level, vascular invasion), closely linked unfavorable outcomes patients, acting as a separate hazardous overall survival. predominantly situated nucleus knockdown impeded growth, migration, invasion capabilities cells vitro, reduced tumor enlargement subcutaneous mouse model. RNA-Seq unveiled silencing lessened CA9 suppressed activity MEK/ERK cascade uncovered acts downstream target facilitating cancer-causing roles Furthermore, revealed be transcriptionally NRF1. DDX11-AS1, NRF1-induced lncRNA, facilitates development upregulating activating cascade.

Language: Английский

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Characterization of adverse reactions to four common targeted drugs for hepatocellular carcinoma in WHO-VigiAccess

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: May 9, 2025

Language: Английский

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LHX3 promotes EMT in hepatoma cell through β-catenin/TCF4 pathway

Medical Oncology, Journal Year: 2024, Volume and Issue: 42(1)

Published: Dec. 19, 2024

Language: Английский

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