Relationships of social isolation and loneliness with healthy aging among older adults DOI Creative Commons
Mengyuan Miao, Fei Fang,

Jie-Qiong Lyu

et al.

BMC Geriatrics, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 23, 2025

Social isolation and loneliness have been recognized as important psychosocial factors affecting human health. We aimed to examine the relationships of social with likelihood healthy aging among older women men. The prospective study included 13,782 female 11,838 male participants who were aged 64 years or had no major chronic diseases during recruitment UK Biobank (2006-2010). All eligible survive age 80 before latest follow-up (December 2021). Healthy was defined survival without diseases. Multivariable logistic regression models used evaluate associations isolation, their combination aging. A total 9130 (58.77%) 6406 men (41.23%) achieved After adjusting for race/ethnicity, associated a significantly 20% 14% lower men, respectively, whereas both sexes similar but statistically non-significant. Among women, association between varied by status (P interaction = 0.031), an inverse limiting socially isolated (OR 0.61; 95% CI: 0.43-0.87). Women 48% 0.52; 0.37-0.73) compared neither, this remained after wide arrange sociodemographic, behavioral, biological, female-specific risk 0.63; 0.44-0.90). Such joint relationship not observed coexistence substantially women. Our findings highlight importance support in extending women's healthspan beyond management traditional factors.

Language: Английский

Social isolation, loneliness, and incident type 2 diabetes mellitus: results from two large prospective cohorts in Europe and East Asia and Mendelian randomization DOI
Yanjun Song, Chen Zhu, Boqun Shi

et al.

EClinicalMedicine, Journal Year: 2023, Volume and Issue: 64, P. 102236 - 102236

Published: Sept. 21, 2023

Language: Английский

Citations

61
The relationship between social isolation, social support, and loneliness with cardiovascular disease and shared risk factors: A narrative review DOI
Achamyeleh Birhanu Teshale,

Htet Lin Htun,

Jessie Hu

et al.

Archives of Gerontology and Geriatrics, Journal Year: 2023, Volume and Issue: 111, P. 105008 - 105008

Published: March 23, 2023

Language: Английский

Citations

23
Prioritizing the primary prevention of heart failure: Measuring, modifying and monitoring risk DOI Creative Commons

Ruchi Patel,

Tejasvi Peesay, Vaishnavi Krishnan

et al.

Progress in Cardiovascular Diseases, Journal Year: 2024, Volume and Issue: 82, P. 2 - 14

Published: Jan. 1, 2024

Language: Английский

Citations

9
Social Isolation and Loneliness increase the risk of Coronary Heart Disease: Insights from a prospective cohort study DOI

Zhaoru Yang,

Ce Liu, He Li

et al.

Social Science & Medicine, Journal Year: 2025, Volume and Issue: 366, P. 117701 - 117701

Published: Jan. 14, 2025

Language: Английский

Citations

1
Frailty and Heart Failure: Clinical Insights, Patient Outcomes and Future Directions DOI Creative Commons

Karol Mirkowski,

Ercole Vellone,

Bernadetta Żółkowska

et al.

Cardiac failure review, Journal Year: 2025, Volume and Issue: 11

Published: Feb. 26, 2025

Frailty is common among heart failure (HF) patients and linked to increased risk of adverse outcomes. Contributing factors include inflammation, sarcopenia neurohormonal issues which diminish physiological reserves accelerate the decline health. Managing frailty in HF requires a multidisciplinary approach address physical, nutritional pharmacological needs. Structured exercise dietary support can improve physical function, while careful medication management, especially with polypharmacy, reduces frailty-related risks. Telemedicine wearable tech facilitate continuous monitoring timely intervention, for those remote areas. Future research should develop standardised assessment tools specific HF, enhancing stratification personalised care. Studies on underlying mechanisms, such as inflammation mitochondrial dysfunction, could lead new therapies. Addressing socioeconomic also care equity. This review summarises clinical characteristics impact highlighting challenges treatment opportunities improving patient

Language: Английский

Citations

1
Social Isolation, Loneliness, and Risk of Microvascular Complications Among Individuals With Type 2 Diabetes Mellitus DOI Creative Commons
Yannis Yan Liang, Yu He, Jinyu Wang

et al.

American Journal of Kidney Diseases, Journal Year: 2024, Volume and Issue: 84(5), P. 557 - 566.e1

Published: June 24, 2024

Rationale & ObjectiveSocial disconnection has been associated with poor cardiometabolic health. This study sought to investigate the associations of social isolation and loneliness diabetic microvascular complications (DMC) among individuals type 2 diabetes mellitus (T2DM) compare these those related traditional risk factors.Study DesignProspective cohort study.Setting ParticipantsA total 24,297 UK Biobank participants T2DM no DMC at baseline.ExposureSocial measured using self-reported questionnaires.OutcomeThe incidence defined as a composite kidney disease, retinopathy, or neuropathy.Analytical ApproachMultivariable cause-specific hazards regression. To relative importance other established factors, R2 values Cox models were calculated.ResultsDuring median follow-up 12.6 years, 5,530 patients documented develop (3,458 2,255 1,146 neuropathy). The highest level was an increased any component (most vs. least: HR: 1.13; 95% CI: 1.05-1.22), especially disease (HR: 1.14, 1.04-1.25) neuropathy 1.31, 1.11-1.53). Any 1.12; 1.02-1.23) 1.16, 1.03-1.30). Social exhibited comparable conventional factors including smoking, blood pressure, physical activity.LimitationsLimited generalizability composition in Study.ConclusionsSocial independently higher incident T2DM, factors. These findings underscore novel potentially modifiable for DMC.

Language: Английский

Citations

8
Observational and genetic evidence disagree on the association between loneliness and risk of multiple diseases DOI Creative Commons
Yannis Yan Liang, Mingqing Zhou, Yu He

et al.

Nature Human Behaviour, Journal Year: 2024, Volume and Issue: 8(11), P. 2209 - 2221

Published: Sept. 16, 2024

Loneliness-the subjective experience of social disconnection-is now widely regarded as a health risk factor. However, whether the associations between loneliness and multiple diseases are consistent with causal effects remains largely unexplored. Here we combined behavioural, genetic hospitalization data from UK Biobank to examine wide range non-overlapping diseases. During median 12.2-year follow-up, was associated greater risks in 13 14 disease categories 30 56 individual considered. Of significantly loneliness, 26 had available for Mendelian randomization (MR) analyses. After Benjamini‒Hochberg correction sensitivity analyses within MR framework, non-causal were identified liability 20 out specific diseases, including cardiovascular type 2 diabetes mellitus, obesity, chronic liver kidney disease, most neurological other common Genetic only potentially causally remaining six Socioeconomic factors, behaviours, baseline depressive symptoms comorbidities explained Overall, our study revealed dissociation observational evidence regarding These findings suggest that may serve potential surrogate marker rather than factor tested here.

Language: Английский

Citations

8
Social isolation, loneliness, and the risk of incident type 2 diabetes mellitus by glycemic status DOI
Yanjun Zhang, Mengyi Liu, Chun Zhou

et al.

Diabetes & Metabolism, Journal Year: 2024, Volume and Issue: 50(2), P. 101517 - 101517

Published: Jan. 20, 2024

Language: Английский

Citations

7
Trajectories of social isolation and loneliness and the risk of incident type 2 diabetes mellitus across genetic risk score DOI
Yilin Chen, Huachen Xue, Sizhi Ai

et al.

Diabetes & Metabolism, Journal Year: 2024, Volume and Issue: 50(3), P. 101526 - 101526

Published: March 6, 2024

Language: Английский

Citations

5
Social isolation and the risk of Parkinson disease in the UK biobank study DOI Creative Commons
Tingting Geng, Yaqi Li, Yinshun Peng

et al.

npj Parkinson s Disease, Journal Year: 2024, Volume and Issue: 10(1)

Published: April 8, 2024

Abstract Parkinson disease (PD) has become one of the most rapidly growing causes disability among older population and social isolation is a major concern in PD community. However, relationship between future risk remains unclear. This study included 192,340 participants aged 60 or who were free dementia at baseline from UK Biobank study. Social was measured using composite score derived three questions on number household, frequency friend/family visits, leisure/social activities. Incident cases identified through electronic health records. Multivariable-adjusted Cox regression models used to compute hazard ratio (HR) 95% confidence interval (CI). Among (mean [standard deviation] age, 64.2 [2.9] years; 103,253 [53.7%] women), 89,075 (46.3%) least isolated group 26,161 (13.6%) group. Over median follow-up 12.5 years, 2048 incident documented. Compared group, multivariable-adjusted HRs (95% CIs) for 1.00 (0.91−1.10) moderately 1.19 (1.05−1.36) ( P - trend = 0.04). The observed association independent genetic susceptibility consistent subgroup analyses. associated with higher regardless risk. Our findings highlighted importance developing screening intervention strategies adults reduce PD.

Language: Английский

Citations

5