JACC Heart Failure, Journal Year: 2023, Volume and Issue: 11(10), P. 1470 - 1470
Published: Oct. 1, 2023
Language: Английский
Journal of the American College of Cardiology, Journal Year: 2024, Volume and Issue: 84(14), P. 1313 - 1324
Published: Sept. 23, 2024
Language: Английский
Citations
6
Current Problems in Cardiology, Journal Year: 2024, Volume and Issue: 49(9), P. 102737 - 102737
Published: June 27, 2024
Language: Английский
Citations
4
BMC Medicine, Journal Year: 2025, Volume and Issue: 23(1)
Published: Feb. 11, 2025
Preventing cardiovascular disease (CVD) in adults with hypertension is essential, but it remains uncertain whether optimizing modifiable factors can eliminate the excess CVD risk associated new-onset hypertension. In this prospective cohort study, 29,597 and no prior (from 2006–2016 surveys) were each matched by age sex to a normotensive control. Eight assessed using American Heart Association's Life's Essential 8 algorithm. We followed participants for incident until December 2020, estimating 10-year lifetime (age 25–95) risks Fine-Gray competing model. Over median follow-up of 9.81 years, had higher (8.97% vs. 6.31%) (45.55% 34.98%) compared controls. After adjusting age, sex, other unmodifiable factors, additional favorable factor was stepwise reduction (P-trend < 0.05). Hypertensive four or more 17% lower (HR 0.83; 95% CI 0.72–0.97) similar 0.90; 0.78–1.05) Notably, protective effect weaker among those early-onset (before 45) than later-onset ≥ 60) (P-interaction hypertension, maintaining at levels comparable that individuals. However, young hypertensive may require aggressive interventions mitigate risk.
Language: Английский
Citations
0
The Journal of Chemical Physics, Journal Year: 2025, Volume and Issue: 162(11)
Published: March 17, 2025
As a novel drug-drug cocrystal, sacubitril allisartan calcium (S086) has demonstrated significant efficacy in the treatment of hypertension and heart failure. S086 two crystalline forms (α ξ) with same molecular composition, but only crystal structure latter been disclosed. Using carboxylic group (COO−) amide (CONH) as structural probes, core structures local dynamics Ca2+ coordination complex unit cell cocrystals were examined by ultrafast two-dimensional infrared (2D IR) spectroscopy. A notable variation molar ratio bidentate to bridging binding types COO− groups that bind was first identified between linear IR This is accompanied greater rigidity α-crystal compared ξ-crystal, evidenced residual amplitude spectral diffusion extracted from time-dependent 2D Vibrational energy transfer tridentate found be faster than suggesting shorter intermolecular distances EXP3174 former. These findings provide dynamical parameters help understand stability releasing mechanisms drug molecules.
Language: Английский
Citations
0
BMC Medicine, Journal Year: 2024, Volume and Issue: 22(1)
Published: March 7, 2024
Abstract Background Diabetes patients are at higher risk for mortality than the general population; however, little is known about whether excess associated with diabetes could be mitigated or nullified via controlling factors. Methods We included 18,535 and 91,745 matched individuals without baseline cancer cardiovascular disease (CVD), followed up from 2006 to 2021. The main exposure was number of optimized factors including glycated hemoglobin < 53 mmol/mole, systolic blood pressure 140 mmHg diastolic 90 mmHg, no albuminuria, non-current smoking low-density lipoprotein cholesterol (LDL-C) 2.5 mmol/L. used Cox proportional hazards models explore association degree factor control all-cause mortality, CVD other mortality. Results Each additional a 16, 10, 21 15% lower respectively. Optimal (controlling 5 factors) 50% (HR 0.50, 95% CI 0.41–0.62), 74% 0.26, 0.16–0.43) 38% 0.62, 0.44–0.87) 4, 3 more controlled factors, respectively, showed compared non-diabetes patients. Conclusions results this study indicate that optimal may eliminate diabetes-related
Language: Английский
Citations
2
ACS Omega, Journal Year: 2024, Volume and Issue: 9(50), P. 49683 - 49691
Published: Dec. 4, 2024
Structurally knowing the active sites of a drug is important for understanding its therapeutic functions. S086 novel angiotensin receptor-neprilysin inhibitor that consists molecular moieties EXP3174 (the metabolite receptor blocker losartan) and sacubitril (a neprilysin prodrug) in 1:1 molar ratio. There are two forms cocrystals S086, namely, ξ-crystal α-crystal, which were formed both via intermolecular coordination bonding to calcium ions, with aid internal water. The binding state multiple carboxyl anions (COO–) Ca2+ was examined this study using infrared (IR) absorption spectroscopy, asymmetric stretching (as) symmetric (ss) modes COO– groups used as IR probes. Ultrafast two-dimensional (2D) spectroscopy utilized spectrally assigning origin by presence or absence interchromophore vibrational coupling. Key structural variation between crystal found: unit cell ξ-crystal, ratio "bridging" "bidentate" types four molecules 2:2, while predicted be 3:1 case α-crystal. However, crystals, believed similarly form "trident" type Ca2+. Our demonstrates linear nonlinear spectroscopies can characterize local structures drugs reveal subtle difference similar structures.
Language: Английский
Citations
2
JACC Heart Failure, Journal Year: 2023, Volume and Issue: 11(6), P. 689 - 690
Published: May 10, 2023
Language: Английский
Citations
4
Healthcare, Journal Year: 2024, Volume and Issue: 12(9), P. 951 - 951
Published: May 6, 2024
Given the aging global population, identifying heart failure (HF) phenotypes has become crucial, as distinct disease characteristics can influence treatment and prognosis in older adults. This study aimed to analyze association between clustering of cardiovascular risk factors HF A cross-sectional epidemiological was conducted with 1322 adults (55% women, mean age 70.4) seen primary health care. Diagnosis performed by a cardiologist based on diagnostic tests medical history. Cardiovascular included hypertension, diabetes, hypercholesterolemia, smoking. Using logistic regression, potential associations were tested. Individual factor analysis showed that or hypercholesterolemia had up 7.6 times higher odds have HF. The cluster where only one instead none increased 53.0%. Additionally, patients having ranged from 3.59 for two-risk 20.61 simultaneous presence all four factors. clusters substantially increasing revealed importance individualizing subgroups pathophysiologies. clinical significance these be beneficial guiding more personalized therapeutic approach.
Language: Английский
Citations
1
European Heart Journal - Quality of Care and Clinical Outcomes, Journal Year: 2024, Volume and Issue: unknown
Published: July 11, 2024
Abstract Aims The relationship between the level of baseline risk factor control and cardiovascular outcomes in hypertensive patients with blood pressure interventions is not well understood. It also unclear whether persuasively associated a lowering strategy. Method results We performed an analysis Strategy Blood Pressure Intervention Elderly Hypertensive Patients (STEP) trial. Participants without complete data were excluded. primary outcome was composite events all-cause mortality. Cox proportional hazard models used to calculate ratio (HR) estimate association levels (≥6, 5, 4, ≤3) outcomes. A total 8337 participants involved analysis, median follow-up period 3.19 years. Each additional uncontrolled 24% higher (HR 1.24, 95% CI 1.11–1.37). Compared optimal control, those ≤3 factors exhibited 1.95, 1.37–2.77). corresponding protective effects multiple modification influenced by intensive or standard antihypertensive treatment (P for interaction = 0.71). Conclusion stepwise observed number patients. more modified, less observed, irrespective different strategies. Comprehensive strategies are warranted reduce disease
Language: Английский
Citations
1
Nutrition Metabolism and Cardiovascular Diseases, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 1, 2024
Language: Английский
Citations
1