Manganese Dioxide Coated Piezoelectric Nanosonosensitizer for Cancer Therapy with Tumor Microenvironment Remodeling and Multienzyme‐Like Catalysis

Small Methods, Journal Year: 2024, Volume and Issue: unknown

Published: April 1, 2024

Abstract Sonodynamic therapy (SDT) as an emerging method for cancer has encountered difficulty in insufficient production of reactive oxygen species (ROS), especially tumor microenvironment (TME) with elevated antioxidants and hypoxic conditions. In this work, the authors have fabricated heterostructured manganese dioxide (MnO 2 )‐coated BaTiO 3 nanoparticles (BTO@M NPs) a piezoelectric sonosensitizer, which exhibits capacity remodeling TME multienzyme‐like catalysis boosting SDT. Benefitting from piezotronic effect, formation p ‐ n junction between MnO BTO built‐in electric field band bending efficiently promotes separation charge carriers, facilitating generation superoxide anion (•O − ) hydroxyl radical (•OH) under ultrasound (US) stimulation. Moreover, BTO@M NPs can catalyze overexpressed hydrogen peroxide (H O to produce replenishing gas source SDT, also deplete antioxidant glutathione (GSH), realizing remodeling. During process, reduced Mn(II) convert H into •OH, further amplifying cellular oxidative damage. With these combination effects, versatile exhibit prominent cytotoxicity growth inhibition against 4T1 breast cancer. This work provides feasible strategy constructing high‐efficiency sonosensitizers

Language: Английский

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Piezoelectric Effect Modulates Nanozyme Activity: Underlying Mechanism and Practical Application

Small, Journal Year: 2023, Volume and Issue: 19(52)

Published: Aug. 27, 2023

Abstract Nanozyme activity relies on surface electron transfer processes. Notably, the piezoelectric effect plays a vital role in influencing nanozyme by generating positive and negative charges materials' surfaces. This article comprehensively reviews potential mechanisms practical applications of regulating through effect. The first elucidates how enables nanozymes to exhibit catalytic activity. It is highlighted that produced this directly participate redox reactions, leading conversion materials from an inactive active state. Moreover, field generated can enhance accelerating rates or reducing binding energy between substrates. Practical are explored subsequent section, including water pollutant degradation, bacterial disinfection, biological detection, tumor therapy, which demonstrate versatile potentials applications. review concludes emphasizing need for further research into nanozymes, suggesting expanding scope types exploring new application areas. Furthermore, promising direction synergistic therapy discussed as inspiring avenue future research.

Language: Английский

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Lattice expansion in ruthenium nanozymes improves catalytic activity and electro-responsiveness for boosting cancer therapy

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Sept. 16, 2024

Nanozymes have been attracting widespread interest for the past decade, especially in field of cancer therapy, due to their intrinsic catalytic activities, strong stability, and ease synthesis. However, enhancing activity tumor microenvironment (TME) remains a major challenge. Herein, we manipulate activities Ru nanozymes via modulating lattice spacing nanocrystals supported on nitrogen-doped carbon support, achieve improvement multiple enzyme-like that can form cascade reactions boost cell killing. In addition, expansion improve responsiveness self-powered electric field, achieving maximized therapeutic outcome. Under electrical stimulation provided by human self-propelled triboelectric device, Ru-based nanozyme (Ru1000) with 5.99% realizes optimal performance outcome breast female tumor-bearing mice. Through theoretical calculations, uncover promote reaction, simultaneously, reducing electron density shifting d-band center active sites. This work provides opportunities improving development nanozymes.

Language: Английский

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Steering Piezocatalytic Therapy for Optimized Tumoricidal Effect

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(33)

Published: May 16, 2024

Abstract Piezocatalysts, because of their mechano‐electrical conversion properties, are exploited for various medical applications, such as sterilization, tissue engineering, biosensing, and disease theranostics. In particular, based on the unique advantage piezoelectric effect, piezocatalytic therapy (PCT) has been developed a novel promising candidate tumor therapy. To optimize utilization piezocatalysts in therapy, comprehensive understanding antitumor mechanism associated with these materials is imperative. Here, action principle elucidated by investigating piezocatalysts, reactants, energy inputs, products. Subsequently, mechanisms PCT have extensively discussed recapitulative follows: restraining cell proliferation, inducing programmed death, hindering metastasis, inhibiting angiogenesis, enhancing immunity. Additionally, optimized therapeutic outcomes PCT‐centric synergistic cancer systematically described. Finally, main challenges future research directions piezocatalysis applied envisioned. It believed that will serve new‐generation ingenious tool treatment.

Language: Английский

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Recent advances in sonodynamic-derived synergistic strategies against bacterial infections

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 508, P. 160962 - 160962

Published: Feb. 25, 2025

Language: Английский

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Recent advances of piezoelectric materials used in sonodynamic therapy of tumor

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 523, P. 216282 - 216282

Published: Oct. 22, 2024

Language: Английский

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Progress of Nanomaterials Based on Manganese Dioxide in the Field of Tumor Diagnosis and Therapy

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 8883 - 8900

Published: Aug. 1, 2024

As a pivotal transition metal oxide, manganese dioxide (MnO

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Thermoresponsive injectable self-healing hydrogel containing polydopamine-coated Fe/Mo-doped TiO2 nanoparticles for efficient synergistic sonodynamic-chemodynamic-photothermal-chemo therapy

Journal of Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 654, P. 1431 - 1446

Published: Oct. 30, 2023

Language: Английский

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Recent advances in chemodynamic nanotherapeutics to overcome multidrug resistance in cancers

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 184, P. 117901 - 117901

Published: Feb. 11, 2025

Language: Английский

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Single‐Atom W Anchored Hexagonal Boron Nitride Piezoelectric Nanosonosensitizer Remodels Tumor Microenvironment for Enhanced Sonodynamic Therapy

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Abstract Sonodynamic therapy (SDT) is a non‐invasive, non‐toxic technique that shows strong potential for tumor treatment: however, its application limited by lack of efficient sonosensitizers, insufficient oxygen supply, and high levels glutathione (GSH) in tumors. In this study, nanosonosensitizer, single‐atom W anchored hexagonal boron nitride@ferrihydrite@trisulfide bond‐modified carboxymethyl chitosan (W‐BN@Fht@TSCM) nanocomplex, developed exhibits an sonosensitizing effect microenvironment remodeling ability, thereby enhancing SDT. W‐BN prepared anchoring monatomic onto the surface nitride (h‐BN) nanosheets, which exhibit superior piezoelectric response to h‐BN owing breaking lattice symmetry. This excellent facilitates production more reactive species under ultrasound conditions. Moreover, H 2 O decomposed Fht nanoparticles, serve as catalase‐like nanoenzymes, alleviating hypoxia providing sufficient substrates. Additionally, TSCM, provides three unique redox sites potential, rapidly efficiently consumes GSH, weakens antioxidant defense mechanism cells enhances efficacy Improving material while demonstrates therapeutic effects reference design SDT nanosystems.

Language: Английский

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