Metal-Organic Frameworks in Gene Delivery DOI
Faisal Raza, Hajra Zafar, Liangdi Jiang

et al.

ACS symposium series, Journal Year: 2024, Volume and Issue: unknown, P. 315 - 338

Published: March 5, 2024

Gene therapies have sparked considerable interest among biotechnology researchers due to their immense potential. This area of research has a lot potential for expanding the scope medicine in terms patient care. The right carrier is essential increasing effectiveness nucleic acid delivery. Despite advancements nanomedicine gene delivery, challenges such as low cellular uptake, inadequate endolysosomal escape, limited systemic circulation, insufficient loading capacity, and uncontrolled release still need be addressed achieve more effective are an exciting that captured many researchers. They offer promising prospects advancing medical treatments. To enhance delivering genetic material, it crucial find carrier. However, there achieving efficient These obstacles include cell difficulty escaping pathway, circulation throughout body, capacity loading, better control over its release. development various nanomedicines, these issues persist. Metal-organic frameworks (MOFs) increasingly popular biological applications Approximately ten years ago result extensive surface precise tunability, high capacities. MOFs highly delivery methods. In this book chapter, you will detailed review highlighting substantial impact research. It discusses preparation procedures, characteristics, advantages MOFs. Additionally, covers noteworthy use

Language: Английский

A Comprehensive Review of Small Interfering RNAs (siRNAs): Mechanism, Therapeutic Targets, and Delivery Strategies for Cancer Therapy DOI Creative Commons
Jiaying Zhang, Bo Chen, Chunyuan Gan

et al.

International Journal of Nanomedicine, Journal Year: 2023, Volume and Issue: Volume 18, P. 7605 - 7635

Published: Dec. 1, 2023

Small interfering RNA (siRNA) delivery by nanocarriers has been identified as a promising strategy in the study and treatment of cancer. Short nucleotide sequences are synthesized exogenously to create siRNA, which triggers interference (RNAi) cells silences target gene expression sequence-specific way. As nucleic acid-based medicine that gained popularity recently, siRNA exhibits novel potential for However, there still many obstacles overcome before clinical devices can be developed. In this review, we discuss prospective targets drug design, explain properties benefits, give an overview current therapeutics Additionally, introduce chemical modifications systems clinically sophisticated classify bioresponsive materials release methodical manner. This review will serve reference researchers developing more precise efficient targeted systems, promoting ongoing advances applications.

Language: Английский

Citations

49
Biomedical application of metal-organic frameworks (MOFs) in cancer therapy: Stimuli-responsive and biomimetic nanocomposites in targeted delivery, phototherapy and diagnosis DOI

Beixu Li,

Milad Ashrafizadeh,

Taiwei Jiao

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 260, P. 129391 - 129391

Published: Jan. 20, 2024

Language: Английский

Citations

45
Zeolites and zeolite imidazolate frameworks on a quest to obtain the ideal biomaterial for biomedical applications: A review DOI Creative Commons
Jakub Matusiak, Agata Przekora, Wοjciech Franus

et al.

Materials Today, Journal Year: 2023, Volume and Issue: 67, P. 495 - 517

Published: July 1, 2023

Human health is considered the most important goal of all. The use different materials in biomedical applications, such as pharmacy (drug delivery systems), regenerative medicine (implantable biomaterials, wound dressings), and or tissue engineering (cell scaffolds), utmost importance right now. Therefore, development new organic–inorganic biomaterials currently hot topic. Zeolites zeolite imidazolate frameworks (ZIFs) belong to chemical groups but their structural similarity superior properties place them among interesting that could be used for various applications. Despite properties, application these aforementioned fields study quite requires further research systematisation. following work reviews recent applications zeolites ZIFs field with strongest emphasis on polymer/zeolite polymer/ZIFs composites hybrid biomaterials. In addition, systems drug carriers medicine, especially treatment osteoporosis, described summarized. Moreover, discussion antimicrobial anticancer mechanisms zeolite/ZIF-based was included. presented literature review clearly shows zeolites/ZIFs loaded are becoming a good alternative already existing therapeutic routes advanced healthcare materials. Some remarks challenges future prospects terms stability-instability, stimuli-responsive materials, toxicity also presented. this tale quest find ideal biomaterial question is: will they succeed? Let us out.

Language: Английский

Citations

35
Get out or die trying: Peptide- and protein-based endosomal escape of RNA therapeutics DOI Creative Commons
A. Klipp, Michael Burger, Jean‐Christophe Leroux

et al.

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 200, P. 115047 - 115047

Published: Aug. 2, 2023

RNA therapeutics offer great potential to transform the biomedical landscape, encompassing treatment of hereditary conditions and development better vaccines. However, delivery RNAs into cell is hampered, among others, by poor endosomal escape. This major hurdle often tackled using special lipids, polymers, or protein-based vectors. In this review, we will focus on most prominent peptide- escape strategies with drugs. We discuss penetrating peptides, which are still incorporated novel transfection systems today promote direct evidence for enhanced action such peptides missing their efficiency, even in permissive culture conditions, rather low. Endosomal help pore forming proteins phospholipases, other hand, allowed generate more efficient systems. These are, however, hampered considerable toxicity immunogenicity. conclude that perfect enhancer has yet be devised. To increase chances success, any new system should tested under relevant guided assays allow quantification

Language: Английский

Citations

31
Oridonin-induced ferroptosis and apoptosis: a dual approach to suppress the growth of osteosarcoma cells DOI Creative Commons
Feifan Zhang,

Yang Hao,

Ning Yang

et al.

BMC Cancer, Journal Year: 2024, Volume and Issue: 24(1)

Published: Feb. 12, 2024

Abstract Background Osteosarcoma (OS) is one of the most common aggressive bone malignancy tumors in adolescents. With application new chemotherapy regimens, finding and effective anti-OS drugs to coordinate program implementation urgent for patients OS. Oridonin had been proved mediate anti-tumor effect on OS cells, but its mechanism has not fully elucidated. Methods The effects oridonin viability, clonal formation migration 143B U2OS cells were detected by CCK-8, colony assays wound-healing test. Kyoto Encyclopedia Genes Genomes (KEGG) enrichment analysis was used explore Western blot (WB), real-time quantitative PCR (qRT-PCR) detect expression levels apoptosis ferroptosis-relative proteins genes. Annexin V-FITC detection kit flow cytometry examination level apoptosis. Iron assay evaluate relative Fe 2+ content. mitochondrial membrane potential lipid peroxidation production determined ROS kit. Results could effectively inhibit survival, metastasis cells. KEGG results indicated that associated with malignant phenotypic signaling pathways proliferation, migration, drug resistance capable inhibiting expressions BAX, cl-caspase3, SLC7A11, GPX4 FTH1 mRNA, while promoting Bcl-2 ACSL4 Additionally, we found promote accumulation reactive oxygen species (ROS) as well reduce potential, these be significantly reversed ferroptosis inhibitor ferrostatin-1 (Fer-1). Conclusion can trigger collaboratively making it a promising agent therapy.

Language: Английский

Citations

11
Challenges and opportunities for improving the druggability of natural product: Why need drug delivery system? DOI Creative Commons
Peng Tang, Tianze Shen, Hairong Wang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 164, P. 114955 - 114955

Published: June 1, 2023

Bioactive natural products (BNPs) are the marrow of medicinal plants, which secondary metabolites organisms and have been most famous drug discovery database. for their enormous number great safety in medical applications. However, BNPs troubled by poor druggability compared with synthesis drugs challenged as medicine (only a few applied clinical settings). In order to find reasonable solution improving BNPs, this review summarizes bioactive nature based on pharmacological research tries explain reasons BNPs. And then focused boosting loaded delivery systems, further concludes advantages systems improvement from perspective nature, discusses why need predicts next direction.

Language: Английский

Citations

19
Advancements and applications of upconversion nanoparticles in wound dressings DOI
Hazal Ezgi̇ Gülteki̇n, Gökçen Yaşayan, Ayça Bal‐Öztürk

et al.

Materials Horizons, Journal Year: 2023, Volume and Issue: 11(2), P. 363 - 387

Published: Nov. 2, 2023

Wound healing is a complex process that requires effective management to prevent infections and promote efficient tissue regeneration. In recent years, upconversion nanoparticles (UCNPs) have emerged as promising materials for wound dressing applications due their unique optical properties potential therapeutic functionalities. These possess enhanced antibacterial when functionalized with agents, helping infections, common complication in healing. They can serve carriers controlled drug delivery, enabling targeted release of agents the site, allowing tailored treatment optimal conditions. ability convert near-infrared (NIR) light into visible and/or ultraviolet (UV) regions, making them suitable (photothermal therapy photodynamic therapy) diagnostic applications. context healing, these be combined other such hydrogels, fibers, metal-organic frameworks (MOFs), graphene oxide,

Language: Английский

Citations

19
A biomimetic camouflaged metal organic framework for enhanced siRNA delivery in the tumor environment DOI

Tongxiang Tao,

Sajid Ur Rehman, Shuai Xu

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(17), P. 4080 - 4096

Published: Jan. 1, 2024

An illustrative depiction highlighting the targeted drug delivery mechanism by bio-functionalized camouflaged MOF nanocarriers that enhances precision targeting diseased cells and minimizing side effects.

Language: Английский

Citations

7
The utilization of metal-organic frameworks in tumor-targeted drug delivery systems DOI Creative Commons
Jiahui Kong, Mengru Cai,

Rongyue Zhu

et al.

Journal of Science Advanced Materials and Devices, Journal Year: 2024, Volume and Issue: 9(3), P. 100770 - 100770

Published: July 23, 2024

Due to the non-specific distribution of drugs in body and low concentration at tumor site traditional chemotherapy, there are challenges associated with significant side effects resistance. Therefore, a drug delivery system (DDS) urgently needs be developed that can precisely target tumors. Metal-organic frameworks (MOFs) possess advantageous characteristics derived from organic inorganic materials, including small particle size, large specific surface area, high loading capacity, adjustable structure pore as well ease modification. Consequently, MOFs offer unique advantages for designing active targeting, passive stimulus-responsive targeting strategies have become hot topic current research on tumor-targeted systems. This review will elaborate application systems perspective different strategies. We hope this paper provide assistance therapy.

Language: Английский

Citations

7
Charting a Path to Tumor Therapy: Mastery of Luminescent Metal–Organic Frameworks for Precise Spatiotemporal Control DOI

Renchi Gao,

Tianxing Xu,

Zhao Wang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(45)

Published: July 11, 2024

Abstract The field of drug delivery has significantly advanced tumor therapy, yet challenges such as the predictability treatment outcomes and real‐time monitoring progression, recurrence or metastasis. Luminescent metal–organic frameworks (L‐MOFs) are a promising solution to overcome these issues. This review offers comprehensive exploration design synthesis L‐MOFs, presenting their crucial optical properties. highlights pivotal role L‐MOFs in enabling precision medicine for driven by performance. Through strategically harnessing light‐manipulated (MOFs), therapeutic precise spatiotemporal control can be achieved. Moreover, this meticulously examines influence photomanipulating MOFs on situ synthesis, introducing catalytic gas therapy. Additionally, gene therapy vectors that utilize light trigger expression responses is also comprehensively explored article, aiming highlight through concludes proposing an artificial intelligence (AI)‐mediated blueprint with pave way innovative approaches manipulation.

Language: Английский

Citations

6