Metal-Organic Frameworks in Gene Delivery DOI
Faisal Raza, Hajra Zafar, Liangdi Jiang

et al.

ACS symposium series, Journal Year: 2024, Volume and Issue: unknown, P. 315 - 338

Published: March 5, 2024

Gene therapies have sparked considerable interest among biotechnology researchers due to their immense potential. This area of research has a lot potential for expanding the scope medicine in terms patient care. The right carrier is essential increasing effectiveness nucleic acid delivery. Despite advancements nanomedicine gene delivery, challenges such as low cellular uptake, inadequate endolysosomal escape, limited systemic circulation, insufficient loading capacity, and uncontrolled release still need be addressed achieve more effective are an exciting that captured many researchers. They offer promising prospects advancing medical treatments. To enhance delivering genetic material, it crucial find carrier. However, there achieving efficient These obstacles include cell difficulty escaping pathway, circulation throughout body, capacity loading, better control over its release. development various nanomedicines, these issues persist. Metal-organic frameworks (MOFs) increasingly popular biological applications Approximately ten years ago result extensive surface precise tunability, high capacities. MOFs highly delivery methods. In this book chapter, you will detailed review highlighting substantial impact research. It discusses preparation procedures, characteristics, advantages MOFs. Additionally, covers noteworthy use

Language: Английский

Role of Functionalized Peptides in Nanomedicine for Effective Cancer Therapy DOI Creative Commons
Kibeom Kim, Myoung‐Hwan Park

Biomedicines, Journal Year: 2024, Volume and Issue: 12(1), P. 202 - 202

Published: Jan. 16, 2024

Peptide-functionalized nanomedicine, which addresses the challenges of specificity and efficacy in drug delivery, is emerging as a pivotal approach for cancer therapy. Globally, remains leading cause mortality, conventional treatments, such chemotherapy, often lack precision adverse effects. The integration peptides into nanomedicine offers promising solution enhancing targeting delivery therapeutic agents. This review focuses on three primary applications peptides: cell-targeting ligands, building blocks self-assembling nanostructures, elements stimuli-responsive systems. Nanoparticles modified with improved cells, minimized damage to healthy tissues, optimized delivery. versatility self-assembled peptide structures makes them an innovative vehicle by leveraging their biocompatibility diverse nanoarchitectures. In particular, mechanism cell death induced novel addition, systems enable precise release response specific conditions tumor microenvironment. use not only augments safety treatments but also suggests new research directions. this review, we introduce functionalization methods using or peptide-modified nanoparticles overcome treatment cancers, including breast cancer, lung colon prostate pancreatic liver skin glioma, osteosarcoma, cervical cancer.

Language: Английский

Citations

5
Exploring metal-organic frameworks in gene delivery: From prostate to lung therapeutics DOI
Moein Safarkhani, Nasim Dana,

Fahimeh Taghavimandi

et al.

Applied Materials Today, Journal Year: 2024, Volume and Issue: 41, P. 102449 - 102449

Published: Oct. 1, 2024

Language: Английский

Citations

4
Understanding of endo/lysosomal escape of nanomaterials in biomedical application DOI Creative Commons
Xin Wang, Haoyu Li, Chen Chen

et al.

Smart Molecules, Journal Year: 2025, Volume and Issue: unknown

Published: March 14, 2025

Abstract Emerging therapies rely on the efficient and specific delivery of targeted agents into cytosol, such as DNA, siRNA proteins. Nanoparticles showed great potentials in safe transportation cargoes; however, entrapment endosomes degradation by enzymes lysosome hindered bioavailability, cytosolic subsequent therapeutic efficacy. In this case, development methods for focuses overcoming major challenge endo/lysosomal escape, which relies nano‐delivery systems. A deeper mechanistic understanding escape will guide more review, we summarize various mechanisms nanoparticles from endo/lysosome, showcase recent progress dissecting approaches based Emphasis lie properties that govern pathway well latest promising applications vaccine genetic engineering field.

Language: Английский

Citations

0
Metal-Organic Frameworks as Therapeutic Chameleons: Revolutionizing the Cancer Therapy Employing Novel Nanoarchitectonics DOI Creative Commons

Sajja Bhanu Prasad,

Akshay Shinde,

Dadi A. Srinivasrao

et al.

Asian Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 101054 - 101054

Published: April 1, 2025

Language: Английский

Citations

0
A biocompatible glycogen based nanoparticle coating with lipid bilayer for intracellular delivery of survivin siRNA to HeLa cells DOI
Zhilan Chen, Min Su, Jiamin Xu

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 92, P. 105371 - 105371

Published: Jan. 14, 2024

Language: Английский

Citations

3
CPP10-Targeted Photoactivatable MOF Nanosystem for Combined Photodynamic Therapy−Chemotherapy of Cancer DOI Creative Commons
Jiahui Kong, Mengru Cai,

Rongyue Zhu

et al.

Journal of Science Advanced Materials and Devices, Journal Year: 2024, Volume and Issue: 9(3), P. 100761 - 100761

Published: June 25, 2024

The annual prevalence of gastric cancer has increased in recent years. Curcumin (CUR) shown great potential the treatment cancer; however, its low bioavailability and poor efficacy hinder widespread clinical application. Additionally, CUR been found to be excellent photosensitizer photodynamic therapy. In this study, Fe-based metal-organic framework (MOF) Fe Tetrakis (4-carboxyphenyl) porphyrin (Fe-TCPP,FT) was used as a mononuclear agent. natural anti-tumor active ingredient loaded both chemotherapeutic agent form nanoparticles CUR@FT (CF). Finally, cell-penetrating peptide (CPP10) modified on surface construct drug delivery system (named CPP10-PEG@CUR@FT, CCF) that could actively target tumor cells while exerting synergistic therapeutic effect chemotherapy This can improve or photosensitizer, high load pH sensitivity FT provide an carrier for efficient CUR. polyethene glycol (PEG)-conjugated CPP10 (PEG-CPP10) coating allows specifically cells, significantly improving absorption vivo vitro biosafety. We evaluated thermal stability, loading capacity, safety vehicle. also assessed performance toxicity various targeting biocompatibility CPP10-PEG@CUR@FT. CPP10-PEG@CUR@FT killing (MKN45) under light much stronger than free Its side effects other organs tissues are low, offering good experimental results showed exerted therapy chemotherapy. summary, our novel CUR-loaded targeted nano offers significant advantages by combining treatment. approach introduces new concept integrating chemotherapy, delivery, potentially providing strategy cancer.

Language: Английский

Citations

3
Spermine delivered by ZIF90 nanoparticles alleviates atherosclerosis by targeted inhibition of macrophage ferroptosis in plaque DOI Creative Commons
Yuwu Chen,

Biyi Xu,

Quan Lin

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 4, 2025

Nowadays, emerging evidence have suggested that the ferroptosis of macrophages could contribute to progression atherosclerosis (AS). Meanwhile, Spermine (Sp) serve as an endogenous small molecule exhibiting a wide range cardiovascular protective effects. Zeolitic imidazolate framework-90 (ZIF90) nanoparticles were synthesized and utilized create novel delivery nanosystem encapsulated with Sp (CD16/32-ZIF90@Sp). The efficacy CD16/32-ZIF90@Sp in protecting against AS was evaluated ApoE-/- mice macrophages, focus on assessing potential adverse effects vivo. exhibited reliable stable within acidic environments ATP sensitivity. effectively reduced cytotoxicity Sp. As is evidenced by vitro vivo experiments, showed precise targeting atherosclerotic plaques ox-LDL-activated macrophages. Furthermore, treatment attenuated macrophage plaque without causing significant side Mechanistically, we found inhibited via improving mitochondrial function upregulating expression level GPX4/xCT. Our study demonstrated CD16/32-modified ZIF90 target plaques, leading inhibition mice. These attributed enhancement ferroptosis, limited

Language: Английский

Citations

0
Construction of intelligent response gene vector based on MOF/Fe3O4/AuNRs for tumor-targeted gene delivery DOI
Liang Liu,

Guowei Qi,

Mingjie Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 277, P. 134313 - 134313

Published: Aug. 3, 2024

Language: Английский

Citations

2
Impact of Ligand Concentration on the Properties of Nucleic-Acid-Encapsulated MOFs and Inflammation Modulation in Prostate Cancer Cells DOI
Shakil Ahmed Polash, Arpita Poddar,

Farah Ahmady

et al.

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(11), P. 7635 - 7645

Published: Nov. 5, 2024

The zeolitic imidazolate framework (ZIF) is one of the most explored metal–organic-framework-based systems for nucleic acid delivery to cancer cells. Current tools exhibit several drawbacks, such as high manufacturing costs, endosomal entrapment, toxicity, and immunogenicity. However, biomimetic mineralization Zn-based ZIFs offers a low-cost facile encapsulation acids at room temperature in aqueous conditions. efficiency its subsequent impact on inflammation cells are influenced by physicochemical properties material. imidazole content determines formation crystallinity ZIF, an optimal ratio ensures well-defined highly crystalline structures. In this study, series siRNA-encapsulated (siRNA@ZIF) were systematically prepared varying ligand-to-metal (L/M) molar ratios. Our study demonstrates that variations ligand concentrations influence structures, particle size, shape siRNA@ZIF particles. At low L/M, two-dimensional particles form with size 1 μm. As L/M increases gradually, decreases, resulting three-dimensional ∼200 nm size. We also observed better stability water using values time-dependent cellular uptake Additionally, no significant biocomposites was found, indicating lack unwanted immune response nonimmunotoxic nature over longer periods (96 h). These findings highlight necessity fine-tuning synthesis chemistry designing efficient ZIF-based versatile platforms acids.

Language: Английский

Citations

2
Novel Strategies for Tumor Treatment: Harnessing ROS-Inducing Active Ingredients from Traditional Chinese Medicine Through Multifunctional Nanoformulations DOI Creative Commons
Zhengguang Zhang, M. Y. Li,

Xiaolong Zhang

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 9659 - 9688

Published: Sept. 1, 2024

Reactive oxygen species (ROS) encompass a diverse group of chemically reactive molecules or ions distinguished by their substantial oxidative potential. Empirical studies have shown that the targeted administration high toxic concentrations ROS can effectively induce tumor cell death in various types. Numerous bioactive ingredients derived from traditional Chinese medicine (TCM), recognized for ROS-inducing properties, demonstrated significant anti-tumor activity. Nonetheless, clinical application has been hindered challenges such as low solubility, limited bioavailability, and poor selectivity. Multifunctional nanoformulations possess potential to overcome these enhance anticancer efficacy active compounds. Through extensive searches academic databases thorough review screening relevant literature, this study aims systematically summarize generalize multiple TCM generation, along with multifunctional nanoformulations, perspectives. The objective is provide new insights references fundamental cancer research treatments. Furthermore, we acknowledge although numerous potentials, potentially offering novel strategies therapy, underlying mechanisms require further comprehensive investigation.

Language: Английский

Citations

1