Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 490, P. 151790 - 151790
Published: April 29, 2024
Language: Английский
Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 687, P. 85 - 94
Published: Feb. 5, 2025
Language: Английский
Citations
2
Colloids and Surfaces B Biointerfaces, Journal Year: 2023, Volume and Issue: 232, P. 113612 - 113612
Published: Oct. 26, 2023
Language: Английский
Citations
27
Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 672, P. 589 - 599
Published: June 3, 2024
Language: Английский
Citations
7
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown
Published: July 8, 2024
Abstract Osteoarthritis is a common degenerative disease characterized by continuous detachment of lubrication factors from damaged cartilage matrix. This study proposes paradigm that combines natural polyanionic polysaccharides (hyaluronic acid, HA) with dopamine (DA) to design synovial factors‐recruiting biomimetic polyphenolized system. The lubricants can use DA's polarity and hydrophilic groups as specific binding sites type II collagen's stably bind surface, further utilize molecular interaction recruit detached, joint endogenous or chondrocytes expressed factors, continuously forming supramolecular complex onto matrix induce lubrication. Simultaneously, the biolubricants also catechol eliminate anionic free radicals resist reactive oxygen species invasion in early stages failure. prepared exhibit low coefficient friction (µ < 0.08), which attributed fluid hydration provided HA DA side chains through dynamic effect interfacial adsorption. Cell animal experiments demonstrate polyphenolic have good biocompatibility promote regeneration. Therefore, developed lubricants‐recruiting potential for treating osteoarthritis, provide theoretical basis other biological tissues problems.
Language: Английский
Citations
6
Engineered Regeneration, Journal Year: 2023, Volume and Issue: 5(1), P. 92 - 110
Published: Dec. 14, 2023
Osteoarthritis (OA) represents an enduring and widespread global burden, causing significant morbidity disability, whose pathology is characterized by persistent inflammation, progressive cartilage degeneration, abnormal bone homeostasis, excessive synovial hyperplasia, resulting from its complex microenvironment. Unfortunately, current therapeutic approaches for OA remain suboptimal, prompting increased interest in advanced nanotechnology as a means to enhance effects. In recent years, progress has been made the development of versatile nanoplatforms designed specific microenvironment OA, promising results introducing concept "OA nanomedicine". Compared conventional therapies like non-steroidal anti-inflammatory drugs (NSAIDs), nanomedicine offers precise targeted, controllable personalized ways therapy, contributing better outcomes. However, comprehensive review consolidating nanomedicine" currently absent literature. Therefore, this review, we aim unravel key pathological microenvironmental characteristics while summarizing properties advantages nanosystems possessing microenvironment-reprogramming capabilities therapy. First, make retrospection features Furthermore, provide overview advances nanomedicine. Eventually, discuss present challenges associated with insights into future prospects clinical-translational lens. By doing so, can foster propel successful nanomedicine, addressing unmet needs
Language: Английский
Citations
16
Molecular & Cellular Proteomics, Journal Year: 2024, Volume and Issue: 23(6), P. 100785 - 100785
Published: May 14, 2024
Language: Английский
Citations
4
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 18, 2025
Abstract Acute lung injury (ALI) refers to damage related cells, typically caused by an uncontrollable inflammatory response, and over‐generated reactive oxygen species (ROS). Increasing evidence suggests that reprogramming redox homeostasis holds significant potentials for the clinical treatment of ALI. Herein, simple synthesis ultra‐small Pd loaded covalent organic framework (COF) (TP@Pd) is reported, which, when combined with near infrared (NIR) irradiation, exhibits nanozyme functionalities, including multiple enzyme mimicking activities broad spectrum ROS scavenging, thereby promoting tissue repair ALI immunotherapy. Mechanistically, through therapeutic strategy TP@Pd+NIR, damaged cells tissues are ameliorated decreasing intracellular levels (total ROS, ·OH ·O 2 − ), downregulating cytokines (IL‐6, TNF‐α IL‐1β), upregulating antioxidant factor level (SOD2), inducing macrophage M2 directional polarization (downregulation iNOS CD86, upregulation IL‐10 CD206), activating immunoregulation (CD4 + /CD8 ratio increase), (upregulation HSP70 CD31), suppressing NF‐κB signaling pathway phosphorylated p65 IκBα). Furthermore, following intravenous (IV) injection in rats, TP@Pd accumulated 6 h, indicating promising efficacy via this administration route. Notably, TP@Pd+NIR demonstrated excellent synergistic effects alleviating inflammation storms, reducing diffuse alveolar damage, accelerating repair. Summarily, work has designed a novel enhancement amelioration, which may serve as approach other diseases.
Language: Английский
Citations
0
International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125548 - 125548
Published: April 1, 2025
Language: Английский
Citations
0
European Polymer Journal, Journal Year: 2023, Volume and Issue: 198, P. 112428 - 112428
Published: Sept. 15, 2023
Language: Английский
Citations
10
Published: Jan. 1, 2025
Language: Английский
Citations
0