Polymers for Advanced Technologies,
Journal Year:
2023,
Volume and Issue:
35(1)
Published: Nov. 28, 2023
Abstract
Theranostics
based
on
magnetic
resonance
imaging
(MRI)
and
photothermal
therapy
can
provide
high‐resolution
with
the
minimum
side
effect
of
cancer
treatment.
In
this
research,
polydopamine
nanoparticles
(PDA‐NPs)
are
synthesized
functionalized
hyaluronic
acid
(HA)
as
a
cancer‐targeting
theranostics
agent.
The
synthesis
PDA‐NPs
an
average
size
25
nm
is
confirmed
by
field
emission
scanning
electron
microscope,
functionalization
HA
ultraviolet–visible
spectroscopy
Fourier
transform
infrared
spectroscopy.
highest
longitudinal
relaxation
rate
(
r
1)
observed
at
Fe
to
PDA
weight
ratio
0.25
MRI
analysis.
MTT
results
confirm
that
PDA/HA‐NPs
ion
concentration
6
μg
mL
−1
not
toxic
(cell
viability,
80%–95%).
result
immunocytochemistry
analysis
shows
binding
78%
human
bone
marrow
mesenchymal
stem
cells
CD44
antigens.
Finally,
irradiated
808
laser
investigate
their
property.
specific
absorption
0.4
mg
iron
determined
107.95
W
g
when
500
mW
cm
−2
power
density.
International Journal of Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
651, P. 123763 - 123763
Published: Jan. 2, 2024
Nanomaterials'
application
in
cancer
therapy
has
been
driven
by
their
ability
to
encapsulate
chemotherapeutic
drugs
as
well
reach
the
tumor
site.
Nevertheless,
nanomedicines'
translation
limited
due
lack
of
specificity
towards
cells.
Although
nanomaterials'
surface
can
be
coated
with
targeting
ligands,
such
mostly
achieved
through
non-covalent
functionalization
strategies
that
are
prone
premature
detachment.
Notwithstanding,
cells
often
establish
resistance
mechanisms
impair
effect
loaded
drugs.
This
bottleneck
may
addressed
using
near-infrared
(NIR)-light
responsive
nanomaterials.
The
NIR-light
triggered
hyperthermic
generated
these
nanomaterials
cause
irreversible
damage
or
sensitize
them
chemotherapeutics'
action.
Herein,
a
novel
covalently
functionalized
targeted
NIR-absorbing
nanomaterial
for
chemo-photothermal
was
developed.
For
such,
dopamine-reduced
graphene
oxide
were
bonded
hyaluronic
acid,
and
then
doxorubicin
(DOX/HA-DOPA-rGO).
produced
showed
suitable
physicochemical
properties,
high
encapsulation
efficiency,
photothermal
capacity.
vitro
studies
revealed
cytocompatible
display
an
improved
uptake
CD44-overexpressing
breast
Importantly,
combination
DOX/HA-DOPA-rGO
NIR
light
reduced
cells'
viability
just
23
%,
showcasing
potential
therapy.
Chemistry of Materials,
Journal Year:
2024,
Volume and Issue:
36(7), P. 3345 - 3358
Published: March 26, 2024
Mussel-inspired
polymeric
materials
have
found
a
broad
range
of
applications
not
only
in
adhesives,
coatings,
and
tough
hydrogels
but
thanks
to
self-healing
stimuli
responsiveness
drug
delivery,
tissue
engineering,
soft
robotics.
These
unique
properties
stem
from
the
reversible
dissociation
transient
bonds
made
by
protic
ligands,
specifically
catechol,
their
fascinating
sensitivity
wide
like
pH.
Nevertheless,
predictability
is
undermined
chemical
side
reactions
possible
physical
phase
separation
also
complex
dynamics
polymer
backbone
its
interplay
with
bonds.
To
address
this
gap,
herein,
we
synthesize
side-chain
supramolecular
polymers
incorporating
nitrocatechol
(nCAT)
groups
along
poly(dimethyl
acrylate)
chains.
We
form
upon
addition
Fe2+/3+
metal
ions
raising
pH
value,
thereby
changing
coordination
geometry
at
varying
hydroxyl
ion
concentrations.
Most
follow
single
relaxation
process,
whose
plateau
modulus
lifetime
can
be
explained
sticky
Rouse
mechanism.
Surprisingly,
low-frequency
mode
appears
progressive
formation
mono
complexes
either
high
concentration
or
low
values,
which
according
SAXS
results
associated
mineralization
ions.
Density
functional
theory
simulations
demonstrate
higher
affinity
Fe3+
tris
complexes,
contrast
bis
selectivity
Fe2+,
explains
highest
that
could
obtained
former.
Our
suggest
control
over
dual
dynamicity
mussel-inspired
hydrogels,
useful
development
novel
materials.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 27, 2024
Abstract
Regenerative
biomedicine
has
emerged
as
a
forefront
area
in
medical
research,
heralding
new
era
of
therapeutic
strategies.
This
review
delineates
the
integration
2D
materials
(2DMs)
within
biomedical
engineering,
leveraging
their
superior
physicochemical
attributes
for
enhance
outcomes.
The
synergistic
interaction
between
biomacromolecules
and
2DMs
is
explored,
demonstrating
potential
to
mitigate
limitations
inherent
each
while
simultaneously
augmenting
beneficial
properties.
In
particular,
incorporating
into
hydrogels
highlights
capability
mechanical
strength
hydrogels,
providing
biomimetic
scaffold
tissue
engineering
regeneration
cancer
diagnosis
therapy.
An
overview
synthetic
methodologies
are
provided
2DMs,
elucidating
dynamics
with
biomacromolecules.
primarily
concentrates
on
applications
biomacromolecule‐reinforced
2DM
across
various
fields,
including
bone
wound
healing,
neural
cardiac
well
delivery
drugs
genes,
therapy,
biosensing
technologies.
Finally,
discusses
existing
challenges
future
outlook
developing
using
underlining
transformative
regenerative
medicine.
Biomimetics,
Journal Year:
2025,
Volume and Issue:
10(4), P. 206 - 206
Published: March 26, 2025
The
application
background
of
mussel-inspired
materials
is
based
on
the
unique
underwater
adhesive
ability
marine
mussels,
which
has
inspired
researchers
to
develop
bionic
with
strong
adhesion,
self-healing
ability,
biocompatibility,
and
environmental
friendliness.
Specifically,
3,
4-dihydroxyphenylalanine
(DOPA)
in
mussel
byssus
able
form
non-covalent
forces
a
variety
surfaces,
are
critical
for
mussel's
adhesion
enable
material
dissipate
energy
repair
itself
under
external
forces.
Mussel-inspired
hydrogels
ideal
medical
due
their
physical
chemical
properties,
such
as
excellent
tissue
hemostasis
bacteriostasis,
biosafety,
plasticity.
This
paper
reviewed
chitosan,
cellulose,
hyaluronic
acid,
gelatin,
alginate,
other
biomedical
discussed
advanced
functions
wound
dressings,
including
antibacterial,
anti-inflammatory,
antioxidant
hemostasis,
transport,
self-healing,
stimulating
response,
so
on.
At
same
time,
technical
challenges
limitations
biomimetic
hydrogel
applications
were
further
discussed,
its
potential
solutions
future
research
developments
field
biomedicine
highlighted.
Science Advances,
Journal Year:
2024,
Volume and Issue:
10(33)
Published: Aug. 16, 2024
Ferroptosis,
caused
by
disorders
of
iron
metabolism,
plays
a
critical
role
in
various
diseases,
making
the
regulation
metabolism
essential
for
tissue
repair.
In
our
analysis
degenerated
intervertebral
disc
tissue,
we
observe
positive
correlation
between
concentration
extracellular
ions
(ex-iron)
and
severity
ferroptosis
degeneration
(IVDD).
Hence,
inspired
magnets
attracting
metals,
combine
polyether
F127
diacrylate
(FDA)
with
tannin
(TA)
to
construct
magnetically
hydrogel
(FDA-TA).
This
demonstrates
capability
adsorb
ex-iron
remodel
cells.
Furthermore,
it
exhibits
good
toughness
self-healing
properties.
Notably,
can
activate
PI3K-AKT
pathway
inhibit
nuclear
receptor
coactivator
4–mediated
ferritinophagy
under
enrichment
conditions.
The
curative
effect
related
mechanism
are
further
confirmed
vivo.
Consequently,
on
basis
pathological
mechanism,
targeted
is
designed
reshape
offering
insights
ChemistrySelect,
Journal Year:
2025,
Volume and Issue:
10(8)
Published: Feb. 1, 2025
Abstract
Chronic
wounds,
as
a
kind
of
long‐term
disease
that
is
difficult
to
cure,
are
challenged
in
healthcare,
placing
substantial
physical,
emotional,
and
economic
burdens
on
patients
society.
Effective
treatment
chronic
wounds
essential
for
improving
patient
quality
life,
reducing
healthcare
costs,
alleviating
the
strain
medical
resources.
Hydrogel
materials
have
emerged
promising
candidates
wound
due
their
exceptional
adaptability
environments
ability
deliver
various
therapeutic
agents,
effectively
promoting
healing
wounds.
However,
wide
array
available
with
diverse
functionalities
presents
challenge
selecting
most
appropriate
components
synthesizing
hydrogel
dressings.
This
review
summarizes
common
materials,
including
properties,
cross‐linking
methods,
applications.
Additionally,
it
systematically
categorizes
different
elucidating
action
mechanisms
effects.
Furthermore,
this
work
offers
guidance
material
selection
dressing
design
based
characteristics
Finally,
challenges
future
perspectives
composite
hydrogels
field
dressings
discussed.
provides
readers
comprehensive
understanding
reliable
basis
synthesize
ideal
