Polymers for Advanced Technologies,
Journal Year:
2023,
Volume and Issue:
35(1)
Published: Nov. 28, 2023
Abstract
Theranostics
based
on
magnetic
resonance
imaging
(MRI)
and
photothermal
therapy
can
provide
high‐resolution
with
the
minimum
side
effect
of
cancer
treatment.
In
this
research,
polydopamine
nanoparticles
(PDA‐NPs)
are
synthesized
functionalized
hyaluronic
acid
(HA)
as
a
cancer‐targeting
theranostics
agent.
The
synthesis
PDA‐NPs
an
average
size
25
nm
is
confirmed
by
field
emission
scanning
electron
microscope,
functionalization
HA
ultraviolet–visible
spectroscopy
Fourier
transform
infrared
spectroscopy.
highest
longitudinal
relaxation
rate
(
r
1)
observed
at
Fe
to
PDA
weight
ratio
0.25
MRI
analysis.
MTT
results
confirm
that
PDA/HA‐NPs
ion
concentration
6
μg
mL
−1
not
toxic
(cell
viability,
80%–95%).
result
immunocytochemistry
analysis
shows
binding
78%
human
bone
marrow
mesenchymal
stem
cells
CD44
antigens.
Finally,
irradiated
808
laser
investigate
their
property.
specific
absorption
0.4
mg
iron
determined
107.95
W
g
when
500
mW
cm
−2
power
density.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: April 25, 2024
Osteosarcoma
(OS)
is
the
most
common
primary
malignant
bone
tumor.
In
clinic,
usual
strategies
for
OS
treatment
include
surgery,
chemotherapy,
and
radiation.
However,
all
of
these
therapies
have
complications
that
cannot
be
ignored.
Therefore,
search
better
treatments
urgent.
Black
phosphorus
(BP),
a
rising
star
2D
inorganic
nanoparticles,
has
shown
excellent
results
in
therapy
due
to
its
outstanding
photothermal,
photodynamic,
biodegradable
biocompatible
properties.
This
review
aims
present
current
advances
use
BP
nanoparticles
therapy,
including
synthesis
properties
types
modification
nanoparticles.
addition,
we
discussed
comprehensively
application
single,
dual,
multimodal
synergistic
therapies,
as
well
studies
about
regeneration
antibacterial
Finally,
summarized
conclusions,
limitations
perspectives
therapy.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 24, 2024
Postoperative
tumor
recurrence
and
wound
infection
remain
significant
clinical
challenges
in
surgery,
often
requiring
adjuvant
therapies.
The
combination
treatment
of
photothermal
therapy
(PTT)
chemodynamic
(CDT)
has
proven
to
be
effective
cancer
infection.
However,
the
hyperthermia
during
PTT
increases
risk
normal
tissue
damage,
severely
impeding
its
application.
Moreover,
efficacy
CDT
is
limited
by
insufficient
hydrogen
peroxide
(H
Molecular Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
21(2), P. 581 - 595
Published: Dec. 22, 2023
Currently,
there
is
an
inherent
contradiction
between
the
multifunctionality
and
excellent
biocompatibility
of
anticancer
drug
nanocarriers,
which
limits
their
application.
Therefore,
to
overcome
this
limitation,
we
aimed
develop
a
biocompatible
delivery
system
for
treatment
hepatocellular
carcinoma
(HCC).
In
study,
employed
poly(3-hydroxybutyrate-
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 29, 2024
Abstract
The
challenges
of
multi‐pathway
immune
resistance
and
systemic
toxicity
caused
by
the
direct
injection
checkpoint
inhibitors
are
critical
factors
that
compromise
effectiveness
clinical
blockade
therapy.
In
this
context,
natural
polyphenols
have
been
employed
as
primary
component
to
construct
a
targeted
acid‐responsive
PD‐L1
antibody
(αPD‐L1)
delivery
nanoplatform.
This
platform
incorporates
garcinol,
an
inhibitor
Nuclear
Factor
Kappa‐B
(NF‐κB)
signaling
pathway,
regulate
pro‐tumor
escape
cytokines
regulatory
T
cells.
Additionally,
nanoplatform
has
verified
induce
immunogenic
cell
death
(ICD),
which
promotes
maturation
dendritic
cells
enhances
activity
cytotoxic
lymphocytes.
vivo
in
vitro
experimental
results
demonstrated
can
boost
response
through
NF‐κB
blocking/ICD
inducing
three‐pronged
strategy,
thereby
effectively
combating
tumor
growth
metastasis.
