Polymers for Advanced Technologies,
Journal Year:
2023,
Volume and Issue:
35(1)
Published: Nov. 28, 2023
Abstract
Theranostics
based
on
magnetic
resonance
imaging
(MRI)
and
photothermal
therapy
can
provide
high‐resolution
with
the
minimum
side
effect
of
cancer
treatment.
In
this
research,
polydopamine
nanoparticles
(PDA‐NPs)
are
synthesized
functionalized
hyaluronic
acid
(HA)
as
a
cancer‐targeting
theranostics
agent.
The
synthesis
PDA‐NPs
an
average
size
25
nm
is
confirmed
by
field
emission
scanning
electron
microscope,
functionalization
HA
ultraviolet–visible
spectroscopy
Fourier
transform
infrared
spectroscopy.
highest
longitudinal
relaxation
rate
(
r
1)
observed
at
Fe
to
PDA
weight
ratio
0.25
MRI
analysis.
MTT
results
confirm
that
PDA/HA‐NPs
ion
concentration
6
μg
mL
−1
not
toxic
(cell
viability,
80%–95%).
result
immunocytochemistry
analysis
shows
binding
78%
human
bone
marrow
mesenchymal
stem
cells
CD44
antigens.
Finally,
irradiated
808
laser
investigate
their
property.
specific
absorption
0.4
mg
iron
determined
107.95
W
g
when
500
mW
cm
−2
power
density.
Royal Society of Chemistry eBooks,
Journal Year:
2024,
Volume and Issue:
unknown, P. 244 - 263
Published: July 19, 2024
The
treatment
of
microbial
infections
is
hampered
by
the
development
resistance
microbes
to
antimicrobial
drugs.
To
overcome
drug
resistance,
delivery
systems
have
been
widely
developed
and
studied.
Injectable
gels
are
that
exhibit
a
sol–gel
transition
under
mild
conditions.
They
offer
several
advantages,
such
as
enhanced
patient
compliance,
ease
application,
prolonged
delivery,
flexibility,
overcoming
side
effects
common
with
systemic
promoting
localized
for
site-specific
action,
controlled
kinetics,
periods,
etc.
Several
research
reports
revealed
promising
results
require
further
studies.
also
explored
infections,
osteomyelitis,
uveitis,
cytomegalovirus
retinitis,
transplant
orthopaedic
postoperative
HIV,
meningitis,
HPV,
sepsis,
dental
acute
bacterial
rhinosinusitis,
infected
irregular
tubular
fistula
in
anus
muscle,
candidiasis,
therapeutic
efficacy
reported
injectable
reveals
there
still
crucial
need
them
be
investigated.
However,
it
important
highlight
few
on
their
applications
fungal
infections.
This
chapter
comprehensive
biomedical
Polymers for Advanced Technologies,
Journal Year:
2023,
Volume and Issue:
35(1)
Published: Nov. 28, 2023
Abstract
Theranostics
based
on
magnetic
resonance
imaging
(MRI)
and
photothermal
therapy
can
provide
high‐resolution
with
the
minimum
side
effect
of
cancer
treatment.
In
this
research,
polydopamine
nanoparticles
(PDA‐NPs)
are
synthesized
functionalized
hyaluronic
acid
(HA)
as
a
cancer‐targeting
theranostics
agent.
The
synthesis
PDA‐NPs
an
average
size
25
nm
is
confirmed
by
field
emission
scanning
electron
microscope,
functionalization
HA
ultraviolet–visible
spectroscopy
Fourier
transform
infrared
spectroscopy.
highest
longitudinal
relaxation
rate
(
r
1)
observed
at
Fe
to
PDA
weight
ratio
0.25
MRI
analysis.
MTT
results
confirm
that
PDA/HA‐NPs
ion
concentration
6
μg
mL
−1
not
toxic
(cell
viability,
80%–95%).
result
immunocytochemistry
analysis
shows
binding
78%
human
bone
marrow
mesenchymal
stem
cells
CD44
antigens.
Finally,
irradiated
808
laser
investigate
their
property.
specific
absorption
0.4
mg
iron
determined
107.95
W
g
when
500
mW
cm
−2
power
density.
