Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: May 6, 2024
Poly-ether-ether-ketone
(PEEK)
is
a
biomedical
plastic
that
can
be
used
for
orthopedic
implants,
but
it
offers
poor
antibacterial
properties
and
bioactivity.
In
this
study,
PEEK
was
sulfonated
with
the
obtained
porous
structure
adsorbing
graphene
oxide
(GO).
The
surface
microstructures
of
original
PEEK,
(SPEEK),
GO-grafted
(GO-SPEEK)
were
characterized.
results
revealed
GO-SPEEK
3D
exhibiting
superior
hydrophilicity
to
PEEK.
Although
SPEEK
shown
possess
antimicrobial
against
both
Escherichia
coli
Staphylococcus
aureus
,
bactericidal
effect
even
more
significant
GO-SPEEK,
at
about
86%
94%,
respectively.
addition,
in
vitro
simulated-body-fluid
immersion
cell
experiments
indicated
had
much
better
hydroxyapatite
(HA)-precipitation
induction
capacity
cell–material
interactions
(e.g.,
adhesion,
proliferation,
osteodifferentiation,
extracellular
matrix
mineralization.
tensile
test
mechanical
maintained
after
modification,
as
has
comparable
values
elastic
modulus
strength
Our
investigation
sought
method
simultaneously
endow
good
bioactivity
well
properties,
providing
theoretical
basis
developing
high-performance
implants
clinic.
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(5), P. 1379 - 1392
Published: Jan. 1, 2024
The
constructed
ZnS–Ti
3
C
2
/PLLA
scaffolds
were
able
to
release
H
S
gas
disrupt
biofilm
and
further
remove
bacteria
through
photothermal.
In
addition,
the
Zn
2+
released
from
composite
could
promote
osteogenic
differentiation
of
BMSCs.
Small,
Journal Year:
2024,
Volume and Issue:
20(29)
Published: Feb. 20, 2024
As
the
global
population
ages,
bone
diseases
have
become
increasingly
prevalent
in
clinical
settings.
These
conditions
often
involve
detrimental
factors
such
as
infection,
inflammation,
and
oxidative
stress
that
disrupt
homeostasis.
Addressing
these
disorders
requires
exogenous
strategies
to
regulate
osteogenic
microenvironment
(OME).
The
regulation
of
OME
can
be
divided
into
four
processes:
induction,
modulation,
protection,
support,
each
serving
a
specific
purpose.
To
this
end,
metal-organic
frameworks
(MOFs)
are
an
emerging
focus
nanomedicine,
which
show
tremendous
potential
due
their
superior
delivery
capability.
MOFs
play
numerous
roles
metal
ion
donors,
drug
carriers,
nanozymes,
photosensitizers,
been
extensively
explored
recent
studies.
This
review
presents
comprehensive
introduction
by
MOF-based
nanomaterials.
By
discussing
various
functional
MOF
composites,
work
aims
inspire
guide
creation
sophisticated
efficient
nanomaterials
for
disease
management.
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(35), P. 8543 - 8576
Published: Jan. 1, 2024
Applications
of
nano-MOFs
in
bone
tissue
engineering,
wound
healing,
and
others,
including
periodontitis,
tendon
repair,
nerve
cardiovascular
disease.
Created
with
BioRender.com.
Materials Today Bio,
Journal Year:
2023,
Volume and Issue:
24, P. 100929 - 100929
Published: Dec. 29, 2023
The
immune
microenvironment
plays
a
pivotal
role
in
osteoanagenesis.
Biomaterials
can
modulate
osteogenic
efficacy
by
inducing
specific
local
reactions.
As
3D-printing
technology
advances,
digital
light
projection
printing
has
emerged
as
promising
method
for
creating
large
scale,
high-precision
biomaterial
scaffolds.
By
adjusting
the
solid
content
and
sintering
conditions
during
printing,
pore
size
of
biomaterials
be
meticulously
controlled.
Yet,
systematic
influence
on
remains
uncharted.
We
fabricated
3D-printed
hydroxyapatite
bioceramic
scaffolds
with
three
distinct
sizes:
400
μm,
600
800
μm.
Our
study
revealed
that
μm
promote
macrophage
M2
polarization,
which
is
achieved
upregulating
interferon−beta
HIF-1α
production.
When
these
materials
were
implanted
subcutaneously
rats
within
rabbit
skulls,
we
observed
notably
improved
long-term
inflammatory
response,
fostered
vascular
proliferation,
augmented
new
bone
growth.
This
research
paves
way
innovative
therapeutic
strategies
treating
segmental
defects
clinical
settings.
