A self-assembling graphene oxide coating for enhanced bactericidal and osteogenic properties of poly-ether-ether-ketone DOI Creative Commons
Run Huang,

Yingjian Gu,

Yeju Yuan

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: May 6, 2024

Poly-ether-ether-ketone (PEEK) is a biomedical plastic that can be used for orthopedic implants, but it offers poor antibacterial properties and bioactivity. In this study, PEEK was sulfonated with the obtained porous structure adsorbing graphene oxide (GO). The surface microstructures of original PEEK, (SPEEK), GO-grafted (GO-SPEEK) were characterized. results revealed GO-SPEEK 3D exhibiting superior hydrophilicity to PEEK. Although SPEEK shown possess antimicrobial against both Escherichia coli Staphylococcus aureus , bactericidal effect even more significant GO-SPEEK, at about 86% 94%, respectively. addition, in vitro simulated-body-fluid immersion cell experiments indicated had much better hydroxyapatite (HA)-precipitation induction capacity cell–material interactions (e.g., adhesion, proliferation, osteodifferentiation, extracellular matrix mineralization. tensile test mechanical maintained after modification, as has comparable values elastic modulus strength Our investigation sought method simultaneously endow good bioactivity well properties, providing theoretical basis developing high-performance implants clinic.

Language: Английский

Two-Dimensional SiH/g-C3N4 van der Waals Type-II Heterojunction Photocatalyst: A New Effective and Promising Photocatalytic Material DOI Open Access
Qi Wang,

Qian Zhu,

Lei Cao

et al.

Coatings, Journal Year: 2024, Volume and Issue: 14(3), P. 263 - 263

Published: Feb. 22, 2024

The two-dimensional layered heterostructure have been demonstrated as an effective method for achieving efficient photocatalytic hydrogen production. In this work, we propose, the first time, creation of van der Waals heterostructures from monolayers SiH and g-C3N4 using first-principle calculations. We also systematically investigated additional properties such electronic structure optical behavior composed monolayers. results study show that SiH/g-C3N4 is categorized a type-II heterostructure, which has bandgap 2.268 eV. Furthermore, interface was observed to efficiently separate transfer photogenerated charges, resulting in enhanced redox performance. Moreover, calculation HOMO (Highest occupied molecular orbital) LUMO (Least unoccupied charge density difference can further confirm heterojunction heterojunction, excellent production water decomposition addition, exhibited HER (Hydrogen evolution reaction) efficiency. This essential process splitting. heterojunctions, potential required splitting spanned by band edge potential. Calculating absorption spectra, it discovered possesses outstanding within visible-light range, implying its high efficiency research provides broader direction investigation novel photocatalysts offers theoretical guidance future photocatalysts.

Language: Английский

Citations

4
Self-assembled water soluble and bone-targeting phosphorylated quercetin ameliorates postmenopausal osteoporosis in ovariectomy mice DOI
Peng Luo,

Yanlong Zhong,

Xiaowei Yang

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 249, P. 114495 - 114495

Published: Jan. 5, 2025

Language: Английский

Citations

0
Enhancement of stability and activity of zinc carbonate nanoparticles using chitosan, hydroxyethyl cellulose, methyl cellulose and hyaluronic acid for multifaceted applications in medicine DOI
А.В. Блинов, Zafar Rekhman,

Mariya Yasnaya

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 139768 - 139768

Published: Jan. 1, 2025

Language: Английский

Citations

0
Near-Infrared Light-Triggered Photothermal-Pyroelectric Scaffold Offering Wireless Electrical Stimulation Accelerates Nerve Repair DOI
Cijun Shuai, Feng Ding,

Xiong Shuai

et al.

ACS Applied Polymer Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

Although electrical stimulation had considerable potential for accelerating nerve repair, its future application was confined by the need an external power supply and a limited range of action. Herein, scaffold with wireless cell recruitment function constructed incorporating polyethylenimine (PEI)-modified reduced graphene oxide (rGO) into pyroelectric polyvinylidene fluoride (PVDF) fabricated via laser additive manufacturing technique. Once irradiated near-infrared light (NIR), rGO dispersed in PVDF matrix could form numerous micro/nanoscaled thermal gradient fields through photothermal conversion effect. These further induce to spontaneously polarize release surface charges, thereby achieving stimulation. More importantly, positively charged amino groups on PEI recruit negatively cells electrostatic interactions, thus realizing better The qPCR results upregulated neuronal markers Tuj, GFAP, Nestin demonstrated that generated effectively bone marrow mesenchymal stem differentiate neurons. Further mechanisms revealed enhanced differentiation mainly attributed promoting calcium influx opening gated ion channels. In summary, this work holds great promise treatment repair.

Language: Английский

Citations

0
Advances in Wearable Nanomaterial-Based Sensors for Environmental and Health Monitoring: A Comprehensive Review DOI

Sikandar Aftab,

Ganesh Koyyada, Najaf Rubab

et al.

Journal of environmental chemical engineering, Journal Year: 2025, Volume and Issue: unknown, P. 115788 - 115788

Published: Feb. 1, 2025

Language: Английский

Citations

0
Controlled-Release of Cinnamaldehyde from MXene/ZIF8/Gelatin Composite Coatings: An Integrated Strategy to Combat Implant-Associated Infection DOI

Jiaxin Guan,

Xiaofeng Wang,

Zhi Hui Tian

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 251, P. 114615 - 114615

Published: March 7, 2025

Language: Английский

Citations

0
Tricalcium silicate enhanced by silver nanoparticles-bacterial cellulose for dental restoration DOI
Wenping Li, Junjie Yu, Chen Chen

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141862 - 141862

Published: March 1, 2025

Language: Английский

Citations

0
SrCO3@PCL/PDA Composite Scaffold Promote Osteoporotic Bone Regeneration Through Immune Regulation DOI
Jianhang Du, Xiaogang Bao,

Wen Jing

et al.

Composites Part B Engineering, Journal Year: 2025, Volume and Issue: unknown, P. 112406 - 112406

Published: March 1, 2025

Language: Английский

Citations

0
In vitro assessment of the osteogenic and antibacterial capabilities of Mg-MOF particles with encapsulated levofloxacin within polydopamine DOI
Wei Xiong,

Yuxiang Zhou,

Yuyi Li

et al.

Published: April 10, 2025

Abstract Infectious bone defect is a condition where infection and occur simultaneously. The simultaneous achievement of effective antimicrobial management enhanced regeneration continues to present major hurdle in musculoskeletal therapeutics. To address these limitations, we have developed novel osteoconductive material, this material (PDA@Mg-MOF-LEV) consists Magnesium-based metal-organic frameworks (Mg-MOF) particles loaded with the antibiotic levofloxacin (LEV) coated polydopamine (PDA), which integrates photothermal therapy delivery combat bacterial drug resistance facilitate tissue regeneration. Under near-infrared (NIR) irradiation, PDA@Mg-MOF-LEV demonstrate superior antibacterial efficacy osteogenic potential. Drug release studies indicate that NIR irradiation significantly increases LEV by 337% Mg ions 196% compared standard conditions. Furthermore, vitro assays confirm markedly enhances activity particles, achieving inhibition rates 97.5 ± 1.45% against Escherichia coli (E. coli) 98.5 2.27% Staphylococcus aureus (S. aureus). mediated not only but also directly stimulates differentiation calcium deposition mBMSCs, positioning as multi-modal therapeutic platform for infective osteogenesis.

Language: Английский

Citations

0
Performance of 3D printed porous polyetheretherketone composite scaffolds combined with nano-hydroxyapatite/carbon fiber in bone tissue engineering: a biological evaluation DOI Creative Commons
Lian Mi, Feng Li, Dian Xu

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: Jan. 25, 2024

Polyetheretherketone (PEEK) has been one of the most promising materials in bone tissue engineering recent years, with characteristics such as biosafety, corrosion resistance, and wear resistance. However, weak bioactivity PEEK leads to its poor integration tissues, restricting application biomedical fields. This research effectively fabricated composite porous scaffolds using a combination PEEK, nano-hydroxyapatite (nHA), carbon fiber (CF) by process fused deposition molding (FDM). The experimental study aimed assess impact varying concentrations nHA CF on biological performance scaffolds. incorporation 10% shown enhance overall mechanical scaffolds, including increased tensile strength improved strength. Additionally, addition 20% resulted significant increase surface roughness high hydrophilicity facilitated vitro inoculation MC3T3-E1 cells. findings demonstrated that inclusion cell attachment proliferation compared other suggests positively influenced properties potentially facilitating regeneration. In biocompatibility experiments showed have good biosafety. investigation osteoblast differentiation revealed intensity calcium nodule staining intensified, along an expression transcription factors alkaline phosphatase activities. These suggest containing favorable for induction. Hence, presents avenue restoration defects field engineering.

Language: Английский

Citations

3