Copper(II) Oxide Spindle-like Nanomotors Decorated with Calcium Peroxide Nanoshell as a New Nanozyme with Photothermal and Chemodynamic Functions Providing ROS Self-Amplification, Glutathione Depletion, and Cu(I)/Cu(II) Recycling DOI Creative Commons

Çağıl Zeynep Süngü Akdoğan,

Esin Akbay, Mehmet Ali Onur

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 25, 2024

Uniform, mesoporous copper(II) oxide nanospindles (CuO NSs) were synthesized via a method based on templated hydrothermal oxidation of copper in the presence monodisperse poly(glycerol dimethacrylate-co-methacrylic acid) nanoparticles (poly(GDMA-co-MAA) NPs). Subsequent decoration CuO NSs with CaO2 nanoshell (CuO@CaO2 yielded nanozyme capable Cu(I)/Cu(II) redox cycling. Activation cycle by exogenously generated H2O2 from significantly enhanced glutathione (GSH) depletion. CuO@CaO2 exhibited 2-fold higher GSH depletion rate compared to pristine NSs. The generation oxygen due catalase (CAT)-like decomposition resulted self-propelled diffusion behavior, characteristic fueled nanomotor. These nanostructures both peroxidase (POD)-like and CAT-like activities self-production aqueous media chemical reaction between water. Usage self-supplied POD-like activity amplified toxic hydroxyl (•OH) radicals, enhancing chemodynamic effect within tumor microenvironment (TME). provided source O2 alleviate hypoxic conditions TME. Under near-infrared laser irradiation, photothermal conversion properties, temperature elevation 25 °C. combined led more effective production •OH radicals cell culture medium. function was further an elevated temperature. To assess therapeutic potential, loaded photosensitizer, chlorine e6 (Ce6), evaluated against T98G glioblastoma cells. synergistic combination photodynamic, photohermal, modalities using CuO@CaO2@Ce6 death than 90% under vitro conditions.

Language: Английский

Hyaluronic Acid Receptor‐Mediated Nanomedicines and Targeted Therapy DOI

Qiuhong Ouyang,

Ying Zhao, Kunyao Xu

et al.

Small Methods, Journal Year: 2024, Volume and Issue: unknown

Published: July 23, 2024

Abstract Hyaluronic acid (HA) is a naturally occurring polysaccharide found in the extracellular matrix with broad applications disease treatment. HA possesses good biocompatibility, biodegradability, and ability to interact various cell surface receptors. Its wide range of molecular weights modifiable chemical groups make it an effective drug carrier for delivery. Additionally, overexpression specific receptors on surfaces many states enhances accumulation drugs at pathological sites through receptor binding. In this review, modification drugs, major proteins, latest advances receptor‐targeted nano delivery systems (DDS) treatment tumors inflammatory diseases are summarized. Furthermore, functions varying vivo selection methods different discussed.

Language: Английский

Citations

14
Enhanced Antitumor Efficacy and Reduced Toxicity in Colorectal Cancer Using a Novel Multifunctional Rg3- Targeting Nanosystem Encapsulated with Oxaliplatin and Calcium Peroxide DOI Creative Commons

Yizhuo Xie,

Ming Zhu,

Han Bao

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 1021 - 1046

Published: Jan. 1, 2025

Colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide. Oxaliplatin (OXA) currently primary chemotherapeutic agent for CRC, but its efficacy limited by tumor microenvironment (TME). Here, we present a combined approach chemotherapy and TME modulation CRC treatment. A multifunctional nanosystem (Rg3-Lip-OXA/CaO2) was established using Ginsenoside Rg3 liposomes targeting glucose transporter 1 overexpressed on surface cells to co-deliver OXA calcium peroxide (CaO2). The CaO2 nanoparticles were synthesized via CaCl2-H2O2 reaction under alkaline conditions characterized X-ray diffraction (XRD) photoelectron spectroscopy (XPS). Rg3-Lip-OXA/CaO2 prepared through thin-film hydration characterized; additionally, stability release behavior studied. O2, H2O2, Ca2+ generation ability in solution HCT116 measured. vitro cellular uptake observed fluorescence microscope flow cytometry. In cytotoxicity evaluated CCK-8 assay, cytometry, live/dead cell staining. vivo effect as well antitumor determined tumor-bearing mice. Finally, acute toxicity investigated ICR mice explore safety. XRD XPS analyses confirmed successful synthesis nanoparticles. exhibited an average particle size approximately 92.98 nm with good sustained behavior. studies optimal Rg3-Lip demonstrated that effectively produced H2O2 Ca2+, resulting significant cytotoxicity. Additionally, revealed substantial growth suppression reduced tumor-associated fibroblasts (TAFs) collagen. Acute indicated markedly drugs. This enhances reduces toxicity, offering promising optimizing treatment potential clinical application.

Language: Английский

Citations

0
Nanoparticle‐Based drug delivery strategies for targeted therapy to hypoxic solid tumors DOI

ZhouXue Wu,

Junru Chen,

Biqiong Wang

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 158081 - 158081

Published: Nov. 1, 2024

Language: Английский

Citations

3
Enhanced Photothermal and Chemodynamic Tumor Therapy by a Cu–Ca-Based Nanoplatform DOI

Minqin Huang,

Erhao Wang,

Xiuju Li

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(9), P. 10928 - 10940

Published: May 1, 2024

In this study, a fascinating nanoplatform, possessing fluorescent imaging, hyperthermia-amplified reactive oxygen species (ROS) generation, and calcium-overloaded comediated multimodal therapeutic effects toward breast malignancy, was innovatively constructed. Accordingly, engineering accurate targeting theranostic scheme can be used for efficacious ablation of carcinoma. Because Cu Ca ions induce ROS generation cytoplasmic overaccumulation, respectively, here, Cu–Ca-based nanoplatform designed by adsorbing indocyanine green (ICG) through the relatively high specific surface area Arg-Gly-Asp peptide (RGD) decorating covalent conjugation. Upon internalization tumor cells, biodegradation triggered under an intracellular weak acid microenvironment; released ICG molecules allowed near-IR (NIR) II imaging photothermal production. Importantly, in guaranteed more efficient Fenton-like reaction-mediated chemodynamic therapy NIR laser exposure. Meanwhile, virus-like hollowed Cu–Ca (VhCu-Ca) created artificial calcium-overloading stress cytoplasm. vitro vivo studies have demonstrated that our proposed integrated advantages targeting, via synergistic treatments. Therefore, multimode developed facile versatile strategy diagnosis suppression tumors.

Language: Английский

Citations

2
Coordination catalysis of metals and polydopamine enables controlled release of CO from MnCO by enhancing oxidative stress and the thermal effect DOI
Wenxin Zhang,

Linyu Li,

Yang Shu

et al.

Inorganic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(16), P. 5196 - 5209

Published: Jan. 1, 2024

Coordination catalysis of Zn/Mn and polydopamine enhanced intracellular oxidative stress thermal effect, thus facilitated release CO from MnCO.

Language: Английский

Citations

2
Advances in Nanotherapeutics for Tumor Treatment by Targeting Calcium Overload DOI
Chenglong Wang,

Junrong Peng,

Yiwei Xiao

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 245, P. 114190 - 114190

Published: Sept. 2, 2024

Language: Английский

Citations

2
GSH responsive AuNRs@TFF nanotheranostic for NIR-II photoacoustic imaging-guided CDT/PTT synergistic cancer therapy DOI

Nan Leng,

Yuzhu Zhou,

Changchun Wen

et al.

Biomaterials Advances, Journal Year: 2024, Volume and Issue: 166, P. 214056 - 214056

Published: Sept. 28, 2024

Language: Английский

Citations

2
Engineering of calcium overload for state-of-the-art tumor therapy DOI
Xinping Liu, Hui Hu, Jinjin Chen

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 501, P. 157747 - 157747

Published: Nov. 17, 2024

Language: Английский

Citations

1
The progress and prospect of calcium peroxide nanoparticles in cancer therapy DOI Creative Commons
S Zhang, Chuanchuan He, Chunxia Zhang

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 101, P. 106114 - 106114

Published: Aug. 31, 2024

Language: Английский

Citations

0
H2O2 Self‐Supplying CaO2/POM@MOF Bimodal Nanogeneration Materials for Photothermal and Chemodynamic Synergistic Antimicrobials DOI
Na Chen, Yuan Li, Yang Pan

et al.

Applied Organometallic Chemistry, Journal Year: 2024, Volume and Issue: 39(1)

Published: Sept. 30, 2024

ABSTRACT The emergence of bacterial resistance has a negative impact on the conventional antimicrobial treatments, and research into development new materials is great significance. Multimodal synergistic exert better effects compared with single modality. In recent years, Polyoxometalate (POM) shown potential in biomedical field due to its high catalytic activity photothermal conversion ability. However, owing small surface area, applications have been greatly limited. Herein, we designed H 2 O self‐supplied CDT PTT bimodal nanogeneration material (i.e., CaO /POM@MOF) possessing larger area for treatment infections, which could release weakly acidic microenvironment infection dual site POM@MOF enhance reaction generate ROS, resulting oxidative stress leakage contents, exposure NIR light generates localized temperature that cause rupture cell membranes denaturation their proteins. Meanwhile, superior stability can fewer metal ions improve biocompatibility. vitro experiments demonstrated /POM@MOF possessed combined effect exhibited excellent efficacy. This work presents promising strategy combat infections.

Language: Английский

Citations

0