Glutathione and acid dual-responsive bismuth-based nanosensitizer for chemo-mediated cancer sonodynamic therapy DOI

Guobo Chen,

Jing Ping,

Jun Du

et al.

Biomedical Materials, Journal Year: 2024, Volume and Issue: 19(4), P. 045035 - 045035

Published: June 10, 2024

Chemotherapeutic agents hold significant clinical potential in combating tumors. However, delivering these drugs to the tumor site for controlled release remains a crucial challenge. In this study, we synthesize and construct glutathione (GSH) acid dual-responsive bismuth-based nano-delivery platform (BOD), aiming sonodynamic enhancement of docetaxel (DTX)-mediated therapy. The bismuth nanomaterial can generate multiple reactive oxygen species under ultrasound stimulation. Furthermore, loading DTX form BOD effectively reduces toxicity bloodstream, ensuring its cytotoxic effect is predominantly exerted at site. be well released high expression GSH acidic microenvironment. Meanwhile, also promote DTX. Results from both

Language: Английский

Bi‐Pt Heterojunction Cascade Reaction Platform for Sono‐Immunotherapy of Tumors via PANoptosis and Ferroptosis DOI
Sijia Wu, Qian Wang, Junhui Du

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 5, 2024

Abstract Sonodynamic therapy (SDT) represents a promising, noninvasive, and precise treatment modality for tumors, demonstrating significant potential in clinical applications. However, the efficiency of sonosensitizers generating reactive oxygen species (ROS) is often limited by rapid electron‐hole recombination. In this study, BiF 3 @BiOI synthesized via co‐precipitation method, followed in‐situ reduction to decorate it with Pt nanoparticles, resulting @BiOI@Pt‐PVP (BBP) nanocomposite enhancing SDT efficacy. The formation heterojunction enhances charge separation ability. decoration nanoparticles narrows bandgap alters band positions Fermi level BBP, which can effectively mitigate recombination pairs facilitate cascade reaction ROS, thereby improving ROS generation ultrasound excitation. Additionally, bismuth ions BBP generated holes consume glutathione, exacerbating cellular oxidative damage, triggering PANoptosis ferroptosis. Furthermore, demonstrate peroxidase‐like activity, catalyzing endogenous hydrogen peroxide oxygen. These functions are helpful against tumors alleviating hypoxic conditions, reshaping microenvironment, modulating immune cell infiltration capacity, efficacy immunotherapy. dual strategy forming heterojunctions sensitization noble metals sono‐catalytic therapy‐induced activation tumor treatment.

Language: Английский

Citations

9
Ternary Schottky Junction for Sonocatalytic Water Splitting in Gas‐Immunotherapy‐Mediated Cancer Treatment DOI Creative Commons
Rui Zhang, Qian Wang, Junjie Pan

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Hydrogen therapy has shown new potential in cancer treatment, particularly high-pressure and hypoxic areas, where it demonstrates the ability to alter tumor microenvironment regulate metabolism. disrupts mitochondrial function of cells, interferes with their energy metabolism, ultimately leads depletion apoptosis. In this study, a sonocatalyst (BPM), is designed generate hydrogen oxygen situ within tumors, further enhancing therapeutic efficacy. The mesocrystalline structure BPM, composed bismuth fluoride, polyoxometalates, molybdenum carbide, significantly improves charge separation electron transfer efficiency under ultrasound irradiation, resulting an efficient water-splitting reaction. By simultaneously generating depleting glutathione, BPM effectively triggers oxidative stress alleviates hypoxia, thereby disrupting inhibiting metabolism cells. Additionally, enhances antitumor immune responses by promoting dendritic cell maturation, activating T lymphocytes, polarizing macrophages toward M1 phenotype, reversing immunosuppressive state microenvironment. results indicate that holds for gas-immunotherapy combination treatments, offering multifunctional strategy improve outcomes.

Language: Английский

Citations

1
Anion exchange regulated charge separation engineering in bismuth nanoflowers for sonocatalytic radio-immunotherapy DOI
Hong Qian, Junjie Pan, Xueyu Li

et al.

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 687, P. 801 - 816

Published: Feb. 17, 2025

Language: Английский

Citations

1
Recent advances of piezoelectric materials used in sonodynamic therapy of tumor DOI

Hsin-I Huang,

Yuqing Miao, Yuhao Li

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 523, P. 216282 - 216282

Published: Oct. 22, 2024

Language: Английский

Citations

8
Overcoming Tumor Hypoxic Bismuth-based Ternary Heterojunctions Enable Defect Modulation-augmented Tumor Sonocatalytic Immunotherapy DOI

Zongyan He,

Qian Wang, Junhui Du

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 315, P. 122962 - 122962

Published: Nov. 12, 2024

Language: Английский

Citations

5
Ultrasound-enhanced dual-responsive bismuth nanocatalysts for alleviating tumor hypoxia and promoting breast cancer sonodynamic-immunotherapy DOI
Junjie Pan, Hong Qian, Jiajia Zheng

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160292 - 160292

Published: Feb. 1, 2025

Language: Английский

Citations

0
Emerging Piezoelectric Sonosensitizer for ROS-Driven Sonodynamic Cancer Therapy DOI Creative Commons
Guiyun Wang,

Yanxia Qi,

Zhuang Liu

et al.

Inorganics, Journal Year: 2025, Volume and Issue: 13(3), P. 71 - 71

Published: Feb. 26, 2025

As a non-invasive modality, sonodynamic therapy (SDT) offers several advantages in cancer treatment, including deep tissue penetration and precise spatiotemporal control, resulting from the interplay between low-intensity ultrasound sonosensitizers. Piezoelectric materials, known for their remarkable capacity of interconversion mechanical electrical energy, have garnered considerable attention biomedical applications, which can serve as pivotal sonosensitizers SDT. These materials generate internal electric fields via ultrasound-induced deformation, modulates alteration charge carriers, thereby initiating surface redox reactions to reactive oxygen species (ROS) realizing therapeutic efficacy This review provides an in-depth exploration piezoelectric utilized SDT, with particular emphasis on recent innovations, elucidation underlying mechanisms, optimization strategies advanced materials. Furthermore, incorporation immunotherapy, photodynamic, chemodynamic, chemotherapy is explored, emphasizing potential enhance outcomes. By examining basic principles effect its contributions this sheds light promising applications oncology. It also highlights future directions improving these expanding clinical utility tumor therapy.

Language: Английский

Citations

0
P–N Type ReS2/Cu2O Nanoheterojunction for Sonodynamic and Chemodynamic Tumor Therapy DOI
Zheng Zhang, Junhui Du, Qingwen Qi

et al.

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 27, 2025

Language: Английский

Citations

0
Biodegradable Bismuth Nanostructures as a Ferroptosis Inducer for Phototherapy of Breast Cancer DOI
Qian Wang, Han Yang,

Fujun Yang

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(12), P. 14406 - 14418

Published: June 7, 2024

The therapeutic efficacy of monotherapy on tumors is often limited due to the constraints tumor response conditions, significantly impacting clinical treatment outcomes. In this study, we design a collaborative nanosystem (BBSP) that combines photodynamic therapy (PDT) and photothermal (PTT). system formulated by doping sulfur ions modulate wide band gap BiF3 semiconductor nanospheres. introduction its combination with bismuth not only enhance light absorption but also introduce oxygen vacancies local surface plasmon resonance effect bismuth. Compared BiF3, reduced carrier separation efficiency improved. Under irradiation 520 nm laser, electrons reduce in process transition meanwhile give energy O2, producing large number reactive species (ROS). Simultaneously, holes valence oxidize glutathione (GSH), coordination ion GSH further depletes GSH. RNA sequencing results reveal downregulation GPX4 cells, inducing ferroptosis. Additionally, sulfide augmented absorption, synergizing heat, thereby increasing oxidative damage inhibiting growth. BBSP emerges as promising strategy for treatment, orchestrating ferroptosis apoptosis through combined application PDT PTT.

Language: Английский

Citations

3
Two-dimensional nanomaterials based on rare earth elements for biomedical applications DOI Creative Commons
Mingjun Bai, Hao Wan, Ying Zhang

et al.

Chemical Science, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Two-dimensional rare earth-containing nanomaterials are promising candidates in biomedical applications such as drug delivery, bio-imaging, antibacterial and cancer treatment due to their unique structure versatile energy levels.

Language: Английский

Citations

2