Nanotherapeutics induced redox resetting of oxidative and nitrosative stress: targeting glutathione-depletion in cancer DOI

Kapil Dangi,

Vijay Kumar, Disha Mittal

et al.

Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 11

Published: April 7, 2025

Cancer cells display a distinctive defense mechanism against any exogenous moieties that renders all treatments inefficient. Glutathione, thiol tripeptide plays paradoxical role in cancer as intracellular glutathione (GSH) are voracious scavengers of free radicals produced by chemotherapy, generation reactive oxygen species (ROS) and nitrogen (RNS). show Warburg effect, wherein the GSH levels exceptionally enhanced to overcome oxidative stress created ROS/RNS production or other generated side products redox reactions. Therefore, resetting is essential maintain homeostasis for cell survival their proliferation trigger escalation levels. Nanotherapeutics have facilitated targeted delivery GSH-depleting agents combination with radiotherapy, novel therapeutic interventions including chemodynamic therapy (CDT), photodynamic (PDT), ferroptosis induction, sonodynamic (SDT), immunotherapy being explored. This review aims compile strategic cells, importance nanotherapeutics depletion target numerous forms programmed death (PCD), apoptosis, ferroptosis, necroptosis, autophagy.

Language: Английский

Paclitaxel prodrug nanoparticles boost antitumor efficacy via hitchhiking of human serum albumin DOI

Shaojin Lu,

Shiyu Zhou,

Xiujuan Xiang

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 679, P. 144 - 154

Published: Oct. 16, 2024

Language: Английский

Citations

4
Self‐Accelerated Nanoregulators for Positive Feedback Ferroptosis‐Immunotherapy DOI Open Access
Xu Zhang, Xinlu Zhang, Qin Fan

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Abstract Activating specific immunity through intelligent delivery of chemotherapeutic drugs shows great potential for effective tumor therapy. However, conventional microenvironment‐responsive nanomedicines are often difficult to achieve both specificity and sensitivity, leading severe adverse effects or limited drug release efficiency. Furthermore, the immunosuppressive microenvironment will also seriously restrict treatment efficacy. In this work, a cascade‐responsive multi‐polyprodrug nanoregulator is developed. Under with high hydrogen peroxide level, nanoregulators can simultaneously (doxorubicin), indoleamine 2,3‐dioxygenase 1 inhibitor (1‐methyl‐tryptophan) cinnamaldehyde in self‐accelerating manner. The combination reactive oxygen species‐induced ferroptosis doxorubicin‐induced apoptosis synergistically enhance immunogenic cell death activate immune response. released1‐methyl‐tryptophan promote cytotoxic T lymphocyte activation reduce escape by inhibiting tryptophan conversion. Meanwhile, it enhances species scavenging cystine/glutamate antiporter expression, achieving positive feedback ferroptosis‐immunotherapy. This work provides self‐accelerated strategy cooperation mode synergistic immunotherapy based on ferroptosis‐apoptosis.

Language: Английский

Citations

0
Histone deacetylase inhibiting nanoprodrugs for enhanced chemodynamic therapy through multistage downregulating glutathione DOI
Yongxin Liu, Xinlu Zhang, Xu Zhang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 305, P. 141184 - 141184

Published: Feb. 17, 2025

Language: Английский

Citations

0
Nanotherapeutics induced redox resetting of oxidative and nitrosative stress: targeting glutathione-depletion in cancer DOI

Kapil Dangi,

Vijay Kumar, Disha Mittal

et al.

Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 11

Published: April 7, 2025

Cancer cells display a distinctive defense mechanism against any exogenous moieties that renders all treatments inefficient. Glutathione, thiol tripeptide plays paradoxical role in cancer as intracellular glutathione (GSH) are voracious scavengers of free radicals produced by chemotherapy, generation reactive oxygen species (ROS) and nitrogen (RNS). show Warburg effect, wherein the GSH levels exceptionally enhanced to overcome oxidative stress created ROS/RNS production or other generated side products redox reactions. Therefore, resetting is essential maintain homeostasis for cell survival their proliferation trigger escalation levels. Nanotherapeutics have facilitated targeted delivery GSH-depleting agents combination with radiotherapy, novel therapeutic interventions including chemodynamic therapy (CDT), photodynamic (PDT), ferroptosis induction, sonodynamic (SDT), immunotherapy being explored. This review aims compile strategic cells, importance nanotherapeutics depletion target numerous forms programmed death (PCD), apoptosis, ferroptosis, necroptosis, autophagy.

Language: Английский

Citations

0