The next frontier in hemorrhagic management: A comprehensive review on development of natural polymer-based injectable hydrogels as promising hemostatic dressings

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 497, P. 155033 - 155033

Published: Aug. 23, 2024

Language: Английский

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Natural polysaccharide-based hydrogels for hemostasis and wound healing: A review

Precision medicine and engineering., Journal Year: 2025, Volume and Issue: unknown, P. 100016 - 100016

Published: Jan. 1, 2025

Language: Английский

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Intelligent response agarose/chitosan hydrogel wound dressing: Synergistic chemotherapy, PDT and PTT effects against bacterial infection

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 139927 - 139927

Published: Jan. 1, 2025

Language: Английский

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Tannic acid based multifunctional hydrogels with mechanical stability for wound healing

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 243, P. 114127 - 114127

Published: July 26, 2024

Language: Английский

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Self-expanding cellulose sponge with enhanced hemostatic ability by tannic acid/metal ion composite coating for highly effective hemostasis of difficult-to-control bleeding wounds

Biomaterials Advances, Journal Year: 2024, Volume and Issue: 166, P. 214025 - 214025

Published: Sept. 3, 2024

Language: Английский

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Real-time quantification of microfluidic hydrogel crosslinking via gas-phase electrophoresis

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 684, P. 201 - 212

Published: Jan. 7, 2025

Language: Английский

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Green biosynthetic silver nanoparticles from Ageratum conyzoides as multifunctional hemostatic agents: combining hemostasis, antibacterial, and anti-inflammatory properties for effective wound healing

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101468 - 101468

Published: Jan. 10, 2025

Widespread interest in new hemostatic agents arises from the challenge of simultaneously satisfying requirements hemostatic, antibacterial, and anti-inflammatory properties while also considering associated economic costs. An ideal hemostasis material should facilitate rapid hemostasis, intervene against infection, promote wound healing, be cost-effective easy to prepare. Herein, we demonstrate that medicinal plant-derived silver nanoparticles (AgNPs) exhibit potential constitute a promising multifunctional reagent library. Biogenic synthesis AgNPs utilizing Ageratum conyzoides extracts, referred as AC-AgNPs, successfully combines with inherent antibacterial activity exhibited by AgNPs. In-vitro coagulation experiments indicate AC-AgNPs have strong effect, which is related their size, concentration, negative charge, they low cytotoxicity hemolysis. Subsequent including scanning electron microscopy, flow cytometry, western blotting, network pharmacology analysis revealed can cause platelet activation aggregation, stimulated kallikrein-kinin system, shorten activated partial thromboplastin prothrombin time, increase fibrinogen content. These findings act on multiple signaling pathways, endogenous exogenous complement activation, aggregation. Furthermore, efficacy demonstrated mouse models tail amputation liver injury, where significantly reduce amount blood loss bleeding time. Our work shows possess anti-inflammatory, capabilities, ultimately facilitating healing. The biogenic plants could candidate for practical application.

Language: Английский

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Multifunctional Hydrogel Integrated Hemangioma Stem Cell‐Derived Nanovesicle‐Loaded Metal‐Polyphenol Network Promotes Diabetic Flap Survival

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Abstract Diabetes‐associated skin defects represent a significant global health challenge. While flap grafts have been preferred treatment for soft‐tissue injuries in diabetic patients, their survival is often compromised by impaired vascularization, infection, and the adverse pathological microenvironment. To address these limitations, hybrid photo‐crosslinkable hydrogel (HPC) integrated hemangioma stem cell‐derived nanovesicle (HemV)‐loaded dual‐metal‐polyphenol network (dMPN) (HemV@dMPN/HPC) developed. HemVs, derived from highly vascularized infantile tissues, play key role promoting cell proliferation angiogenesis. The dMPN facilitates gradual release of copper (Cu 2+ ) magnesium ions (Mg ), stimulating angiogenesis mitigating inflammation. HPC further sustains ion while preserving therapeutic efficacy HemVs. Moreover, both Cu act to confer antibacterial properties, accelerating wound healing. This multifunctional HemV@dMPN/HPC platform offers promising strategy treating large can potentially improve graft survival.

Language: Английский

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Injectable carboxymethyl chitosan/konjac glucomannan/catechin hydrogel with free radical-scavenging, antimicrobial, and pro-healing abilities for infected wound repair

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142572 - 142572

Published: March 1, 2025

Language: Английский

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Functional hydrogels for accelerated wound healing: advances in conductive hydrogels and self-powered electrical stimulation

Journal of Biomaterials Science Polymer Edition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 32

Published: April 14, 2025

Compared to traditional dressings, hydrogel dressings not only protect the wound surface and prevent bacterial infection but also possess excellent moisturizing properties, which can provide an optimal moist environment for healing, exhibit good biocompatibility, making them considered best treatment materials. This review focuses on research status application progress of various functional such as hemostatic, antimicrobial, anti-inflammatory, antioxidant, conductive hydrogels. It proposes combination hydrogels with flexible solar cells form self-powered devices. externally powered devices, this approach reduce carbon footprints by utilizing clean energy, aligning neutrality policy requirements. Additionally, it eliminates need frequent battery replacement or power connections, effectively saving labor operational costs. Self-powered devices convert energy into electrical is conducted site through hydrogels, generating continuous stimulation (ES). guides directional migration keratinocytes fibroblasts toward center wound; activates MAPK/ERK signaling pathway accelerate cell cycle process, upregulates expression vascular endothelial growth factor, thereby inducing proliferation lumen formation. These multiple mechanisms work synergistically promote healing. Finally, provides outlook emergence applications multifunctional stimuli-responsive highlighting common challenges in future development weak mechanical strength poor long-term stability, well feasible solutions these issues.

Language: Английский

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