Materials chemistry horizons., Journal Year: 2024, Volume and Issue: 3(4), P. 1 - 20
Published: Dec. 1, 2024
Language: Английский
Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 687, P. 540 - 551
Published: Feb. 15, 2025
Language: Английский
Citations
0
Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13
Published: April 30, 2025
A notable increase in cancer-related fatalities and morbidity worldwide is attributed to drug resistance. The factors contributing resistance include efflux via ABC transporters, apoptosis evasion, epigenetic alterations, DNA repair mechanisms, the tumor microenvironment, among others. Systemic toxicities associated with conventional cancer diagnostics therapies have led development of alternative approaches, such as nanotechnology, enhance diagnostic precision improve therapeutic outcomes. Nanomaterial, including carbon nanotubes, dendrimers, polymeric micelles, liposomes, shown significant benefits diagnosis treatment due their unique physicochemical properties, biocompatibility, stability, enhanced permeability, retention characteristics, targeted delivery. Building on these advantages, this review conducted through comprehensive analysis recent literature explore principal mechanisms resistance, potential nanomaterials revolutionize selective delivery treatment. Additionally, strategies employed by overcome tumors, pump inhibition, multidrug loading, gene silencing are discussed detail. Furthermore, we examine challenges that limit application impede transition clinical use.
Language: Английский
Citations
0
Nanoscale, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy characterized by limited treatment options and poor prognosis. Nanoparticle-based drug delivery systems have emerged as a promising strategy to enhance cancer therapy efficacy improving targeting, reducing toxicity, enabling multifunctional applications. This review highlights some key types of nanoparticles, including liposomes, polymeric metallic dendrimers, quantum dots, which could effectively improve the various drugs used in chemotherapy, radiotherapy, immunotherapy, offering more precise effective options. With ability stability overcome biological barriers, nanoparticle-based represent transformative for ESCC treatment. Despite challenges, such biocompatibility scalability, future holds great promise, particularly development personalized nanomedicine novel therapeutic approaches targeting tumor microenvironment. ongoing advancements, hold immense potential revolutionize patient outcomes.
Language: Английский
Citations
0
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: April 2, 2025
Traditional treatments for periodontitis are limited by their inability to adequately modulate the immune response and control inflammation. Recently, nucleic acid-modified nanomaterials have attracted significant attention potential in regulating Among these, most nanomaterials, such as spherical acids, tend exhibit pro-inflammatory effects. In this study, we identified first time that poly-T sequence-modified gold nanorods (PTM AuNRs) possess anti-inflammatory properties. The PTM AuNRs demonstrated excellent biocompatibility efficacy treating ligation-induced periodontitis. responses inhibiting differentiation of M1 macrophages reducing cytokine levels through promoting AMPK activation. When administered via local injection, effectively suppress inflammatory cell infiltration, downregulate levels, mitigate collagen fiber degradation alveolar bone loss. Together, these findings highlight a promising innovative therapeutic strategy management.
Language: Английский
Citations
0
Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)
Published: April 24, 2025
Mucosal melanoma, a highly aggressive form of skin cancer, remains challenging to manage due the lack effective therapies. Mucin 18 (MUC18) is overexpressed in both primary and metastatic lesions melanoma but rarely normal tissues. The expression profile makes MUC18 potential target for development therapeutic antibodies or chimeric antigen receptor-T (CAR-T) cell therapy. This study aims generate an CAR-T targeting MUC18-positive evaluate its preclinical antitumor activity. A humanized anti-MUC18 single chain antibody fragment (scFv) was used construct with various designs hinge, transmembrane, co-stimulatory, CD3ζ domains. efficacy cells assessed vitro, rechallenged xenograft models, as well patient-derived (PDX) models human mucosal melanoma. scFv selectively bound high affinity. Various specifically killed could proliferate result exposure antigen. Among them, containing IgG4-derived hinge domain CD28 co-stimulatory demonstrated superior efficiency. Robust tumor regression expansion were observed multiple after treatment IgG4 empowered cells. novel therapy CAR-T, that showed strong potency eradication inhibition relapse. candidate provide promising strategy refractory
Language: Английский
Citations
0
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: May 8, 2025
The development of new CRISPR/Cas9 delivery systems with a synergistic therapeutic mode can provide perspective for efficient tumor treatment. In this work, we developed bionic 2D FeS nanoplatform high loading (FCRM), highlighting the synergy and ferroptosis in regulating heat shock proteins (HSPs) enhanced photothermal therapy (PTT). Due to ultrathin structure pH-response nanosheets, FCRM quickly decompose microenvironment effectively release Fe2+, which be further by process. accurately downregulate level intracellular antiapoptosis protein Survivin. Fe2+ induce lipid peroxidation cells. Ferroptosis regulation Survivin synergistically expression HSPs, thereby reducing resistance cells PTT. Additionally, caused significant magnetic resonance contrast enhancement, aided accurate diagnosis tumors. Therefore, has great potential achieving targeted imaging dual HSPs ferroptosis-gene
Language: Английский
Citations
0
Inorganic Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 25, 2024
The rational collocation and construction of multiphase composite electrode materials with ingenious structures is a key strategic to enhance the electrochemical performance supercapacitors (SCs). Within this project, unique Co9S8@CoAl-LDH/NF core–shell heterostructure consisting CoAl-LDH/NF ultrathin nanosheets sturdily attached Co9S8/NF needle-like nanorods grown in situ on self-supported conductive substrate nickel foam (NF) by an effortless productive multistep hydrothermal method. structure can effectively capacitive properties as well mechanical strength material. Compared single-component (1769.6 mF cm–2 91.6%) (858 85.2%), composites have excellent capacitance (5052.4 cm–2) along exceptional retention (5000 cycles) 98.5% even after undergoing charging discharging. Furthermore, asymmetric SCs fabricated AC/NF exhibit energy density 0.17 mWh at 3.20 mW cm–2. Therefore, innovative presented study holds immense practical potential groundbreaking material realm SCs.
Language: Английский
Citations
1
Materials chemistry horizons., Journal Year: 2024, Volume and Issue: 3(4), P. 1 - 20
Published: Dec. 1, 2024
Language: Английский
Citations
0