ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 12, 2025

The PEGylation of drug-carrying nanoparticles has often been used to prolong blood circulation and improve drug deposition at tumor sites. Nevertheless, the PEG-rich hydrophilic surfaces retard release payloads internalization therapeutic by cancer cells, thus lowering anticancer efficacy. To boost potency combined photodynamic therapy (PDT) photothermal (PTT) against melanoma conquering PEG dilemma, herein, hybrid PEGylated chitosan-covered polydopamine (PDA) (PCPNs) with acidity-elicited detachment ability were fabricated as carriers IR780, a small-molecule photosensitizer for PTT PDT. IR780@PCPNs displayed uniform, solid-like spherical shape sound colloidal stability. Under near-infrared (NIR) irradiation, showed prominent conversion efficiency (ca. 54.6%), robust stability, reduced IR780 photobleaching, sufficient singlet oxygen (1O2) production, glutathione-depleting ability. Moreover, environmental pH being from 7.4 5.0 37 °C, decreased interactions between PCPNs due increased protonation phenolic hydroxyl residues within PDA primary amine groups chitosan accelerated species IR780@PCPNs. Importantly, cellular uptake B16F10 was remarkably promoted in weakly acidic milieu upon driven disintegration acid-labile benzoic imine. With NIR internalized generated hyperthermia 1O2 damage mitochondria, thereby effectively inhibiting proliferation cells. Collectively, our findings present practical strategy amplifying efficacy PDT using PEG-detachable

Language: Английский