ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(50), P. 69045 - 69054
Published: Dec. 5, 2024
Alzheimer's
disease
(AD)
is
one
of
the
most
common
neurodegenerative
diseases,
commonly
affecting
aged,
with
pathophysiological
changes
presenting
15
to
20
years
before
clinical
symptoms.
Early
diagnosis
and
intervention
are
crucial
in
effectively
slowing
progression
AD.
In
current
study,
poly(2-(methacryloyloxy)ethyl
phosphorylcholine)
(PMPC)-functionalized
NaGdF4
nanoparticles
(NaGdF4-PMPC)
were
developed
as
magnetic
resonance
imaging
(MRI)
contrast
agents
for
targeting
alpha
7
nicotinic
acetylcholine
receptors
(α7
nAChRs)
AD
mice.
NaGdF4-PMPC
showed
excellent
biocompatibility,
ability,
MRI
performance,
longitudinal
molar
relaxivity
(r1)
transverse
(r2)
being
1.21-fold
1.33-fold
higher
than
those
agent
Gd-DTPA,
respectively,
resulting
higher-sensitive
MR
angiography.
After
intravenous
injection,
3D
dynamic
contrast-enhanced
(DCE)
images
high-resolution
vasculature
mouse
brain
obtained.
addition,
by
using
NaGdF4-PMPC,
susceptibility-weighted
(SWI)
signals
brains
greatly
retained
compared
healthy
mice
24
h,
emphasizing
ability
NaGdF4-PMPC.
Furthermore,
CD31,
α7
nAChRs,
Thioflavin
S
staining
also
utilized
investigate
relationship
among
vascular
inflammation,
amyloid-β
(Aβ)
deposition
This
work
highlights
a
promising
targeted
strategy
timely
New Journal of Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
The
study
presents
a
Fe
3
O
4
@C@Pt
nanozyme,
modified
with
folic
acid,
that
efficiently
targets
tumor
cells
and
inhibits
growth
through
combined
photothermal
therapy
catalysis.
Alveolar
echinococcosis
(AE)
is
a
serious
parasitic
infectious
disease
that
highly
invasive
and
destructive
to
the
liver
has
high
mortality
rate.
However,
currently,
there
no
effective
targeted
imaging
treatment
method
for
precise
detection
therapy
of
AE.
We
proposed
new
two-step
targeting
strategy
(TSTS)
AE
based
on
poly(lactic-co-glycolic
acid)
(PLGA).
designed
constructed
novel
type
ICG@PLGA@Lips
nanoprobe
with
integrated
properties.
First,
we
used
characteristics
PLGA
gluconeogenic
raw
material
target
during
blood
circulation.
Then,
utilized
specifically
penetrating
shell
achieve
specific
identification
in
liver.
Under
808
nm
laser
excitation,
effectively
achieved
accurate
near-infrared
II
(NIR-II,
900-1700
nm)
fluorescence
methods
through
PDT
effects.
improved
optical
properties
ICG,
while
liposomes
further
biocompatibility
nanoprobe.
As
showed
strong
NIR-II
emission
good
biocompatibility,
advantages
navigation
surgical
resection
lesions.
Thus,
assistance
ICG@PLGA@Lips,
real-time
first
time.
successfully
obtained
vivo
imaging-guided
photodynamic/surgical
This
TSTS-based
exploration
provided
early
AE,
which
expected
significantly
improve
prognosis
patients.
