Delayed Magnetic Resonance Imaging of Alzheimer’s Disease by Using Poly(2-(methacryloyloxy)ethyl phosphorylcholine)-Functionalized Nanoprobes DOI
Wenyue Li, Xinyi Zhang, Chuang Liu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(50), P. 69045 - 69054

Published: Dec. 5, 2024

Alzheimer's disease (AD) is one of the most common neurodegenerative diseases, commonly affecting aged, with pathophysiological changes presenting 15 to 20 years before clinical symptoms. Early diagnosis and intervention are crucial in effectively slowing progression AD. In current study, poly(2-(methacryloyloxy)ethyl phosphorylcholine) (PMPC)-functionalized NaGdF4 nanoparticles (NaGdF4-PMPC) were developed as magnetic resonance imaging (MRI) contrast agents for targeting alpha 7 nicotinic acetylcholine receptors (α7 nAChRs) AD mice. NaGdF4-PMPC showed excellent biocompatibility, ability, MRI performance, longitudinal molar relaxivity (r1) transverse (r2) being 1.21-fold 1.33-fold higher than those agent Gd-DTPA, respectively, resulting higher-sensitive MR angiography. After intravenous injection, 3D dynamic contrast-enhanced (DCE) images high-resolution vasculature mouse brain obtained. addition, by using NaGdF4-PMPC, susceptibility-weighted (SWI) signals brains greatly retained compared healthy mice 24 h, emphasizing ability NaGdF4-PMPC. Furthermore, CD31, α7 nAChRs, Thioflavin S staining also utilized investigate relationship among vascular inflammation, amyloid-β (Aβ) deposition This work highlights a promising targeted strategy timely

Language: Английский

Recent advances in nanomaterials for integrated phototherapy and immunotherapy DOI Creative Commons
Zhuqing Sun, Nannan Wang, Yelin Wu

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 535, P. 216608 - 216608

Published: March 27, 2025

Language: Английский

Citations

0
Targeted Drug Delivery with Photoluminescent Emitters: Applications in Diagnostic DOI
Abayomi Bamisaye, Nelson Oshogwue Etafo, Muyideen Olaitan Bamidele

et al.

Engineering materials, Journal Year: 2025, Volume and Issue: unknown, P. 75 - 119

Published: Jan. 1, 2025

Language: Английский

Citations

0
Recent advances in graphitic carbon nitride-based heterojunction for biomedical applications DOI
Ruilong Jia, Chengen He,

Shan-Shan Wang

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 500, P. 157464 - 157464

Published: Nov. 1, 2024

Language: Английский

Citations

3
A "lysosomal bomb" constructed based on amorphous calcium carbonate to induce tumor apoptosis by amplified sonodynamic therapy DOI

Zhimin Mo,

Yuxuan Luo, Qi Xu

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 245, P. 114287 - 114287

Published: Oct. 2, 2024

Language: Английский

Citations

2
A tumor Microenvironment-triggered protein-binding Near-infrared-II Theranostic nanoplatform for Mild-Temperature photothermal therapy DOI

Wenlong Huang,

Bo Jin,

Huili Gong

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 680, P. 375 - 388

Published: Nov. 9, 2024

Language: Английский

Citations

1
Delayed Magnetic Resonance Imaging of Alzheimer’s Disease by Using Poly(2-(methacryloyloxy)ethyl phosphorylcholine)-Functionalized Nanoprobes DOI
Wenyue Li, Xinyi Zhang, Chuang Liu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(50), P. 69045 - 69054

Published: Dec. 5, 2024

Alzheimer's disease (AD) is one of the most common neurodegenerative diseases, commonly affecting aged, with pathophysiological changes presenting 15 to 20 years before clinical symptoms. Early diagnosis and intervention are crucial in effectively slowing progression AD. In current study, poly(2-(methacryloyloxy)ethyl phosphorylcholine) (PMPC)-functionalized NaGdF4 nanoparticles (NaGdF4-PMPC) were developed as magnetic resonance imaging (MRI) contrast agents for targeting alpha 7 nicotinic acetylcholine receptors (α7 nAChRs) AD mice. NaGdF4-PMPC showed excellent biocompatibility, ability, MRI performance, longitudinal molar relaxivity (r1) transverse (r2) being 1.21-fold 1.33-fold higher than those agent Gd-DTPA, respectively, resulting higher-sensitive MR angiography. After intravenous injection, 3D dynamic contrast-enhanced (DCE) images high-resolution vasculature mouse brain obtained. addition, by using NaGdF4-PMPC, susceptibility-weighted (SWI) signals brains greatly retained compared healthy mice 24 h, emphasizing ability NaGdF4-PMPC. Furthermore, CD31, α7 nAChRs, Thioflavin S staining also utilized investigate relationship among vascular inflammation, amyloid-β (Aβ) deposition This work highlights a promising targeted strategy timely

Language: Английский

Citations

1