Dissolving PEGDA-Based Microneedles to Transdermally Deliver PDA@Cu with Photothermal Properties for Potential Antibacterial Applications DOI
Ya Gao, Hua Huo, Renyuan Zhang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(51), P. 70339 - 70351

Published: Dec. 13, 2024

The stratum corneum of the skin functions as a barrier, obstructing drug absorption and complicating treatment infections caused by pathogens such bacteria, fungi, viruses through topical methods. In this research, microneedle patch was developed, which consists gelatin-sucrose (SG) that encapsulates polydopamine-copper nanoparticles (PDA@Cu) at tip for antibacterial purposes. Poly(ethylene glycol) diacrylate (PEGDA) served primary substrate shaft (PDA@Cu-SG/PEGDA). This engineered to enhance permeability facilitate efficient delivery drugs rapid dissolution tips. Coordinate bonds can be formed between PDA Cu ions, resulting in immobilization particles on surface, aids green synthesis PDA@Cu photothermal particles. SG polymer, contained PDA@Cu, employed fill cavities series centrifugation steps. Subsequently, UV-induced polymerization carried out produce PEGDA microneedles with hydrophilic tips Furthermore, physicochemical characteristics polymer microneedles, including morphology, composition, mechanical strength, were thoroughly characterized. These demonstrated sufficient strength. Owing ability disrupt bacterial membranes, excellent vitro efficacy. We validated activity against Escherichia coli Staphylococcus aureus conducting plate coating assays. results assays indicated minimally invasive strategy achieved broad-spectrum effects; thus, may suitable approach managing polymicrobial during clinical trials.

Language: Английский

Hydrogel contact lenses modified by quaternary chitosan and epigallocatechin gallate with enhancement of antimicrobial for bacterial keratitis DOI
Shuai Lin, Yujun Zheng, Pengfei Xue

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 306, P. 141787 - 141787

Published: March 6, 2025

Language: Английский

Citations

0
Tendon injury repair strategy driven by supramolecular hydrogen bonding and dynamic covalent bond self-assembly microspheres DOI

T. Liu,

Xiaoxuan Ma,

Chenhui Zhu

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162726 - 162726

Published: April 1, 2025

Language: Английский

Citations

0
Bioinspired glycocalyx-mimetic hydrogel enabling photothermal-amplified therapeutic cascade for chronic wound healing DOI

Zongyan Quan,

Fangdie Ye,

Han Yu

et al.

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 694, P. 137669 - 137669

Published: April 24, 2025

Language: Английский

Citations

0
2D cotton fabric coated with 3D chitosan/carbon-black aerogel for continuous efficient solar desalination DOI

Huihui Ren,

Jinjing Hu, Mohammad‐Mahdi Pazuki

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 163276 - 163276

Published: April 1, 2025

Language: Английский

Citations

0
Self-driven charge transfer mechanism of Bi NPs/PCN-224 for enhanced photodynamic antimicrobial chemotherapy effect DOI
Yujia Han, Huadong Zeng, Hongyan Hao

et al.

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 689, P. 137207 - 137207

Published: March 1, 2025

Language: Английский

Citations

0
Chitin, Chitosan and Its Derivatives: Antimicrobials and/or Mitigators of Water DOI Creative Commons

Eva Scarcelli,

Alessia Catalano, Domenico Iacopetta

et al.

Macromol—A Journal of Macromolecular Research, Journal Year: 2025, Volume and Issue: 5(2), P. 15 - 15

Published: April 8, 2025

Antimicrobial resistance (AMR) is a major global health problem, exacerbated by the excessive and inappropriate use of antibiotics in human medicine, animal care agriculture. Therefore, new strategies compounds are needed to overcome this issue. In view, it may be appropriate reconsider existing biomaterials alleviate antibiotic overuse. Chitin, naturally abundant amino mucopolysaccharide, poly-β-1, 4-N-acetylglucosamine (GlcNAc). It white, hard, inelastic, nitrogenous polysaccharide source surface pollution coastal areas. Chitosan derives from partial N-deacetylation chitin originates shells crustaceans fungi cell walls. nontoxic natural antimicrobial polymer approved GRAS (Generally Recognized as Safe United States Food Drug Administration). Chitin chitosan, non-toxic biopolymers, useful for wastewater treatment remove pollutants, such pharmaceuticals, heavy metals dyes. The described features make these biopolymers intriguing investigated their application antibacterials.

Language: Английский

Citations

0
Engineered bioactive glass-chitosan hybrid for dual tissue and bone regeneration multifunctional healing DOI

Yu-Chien Lin,

Susaritha Ramanathan, Huey-Yuan Wang

et al.

Biomaterials Advances, Journal Year: 2025, Volume and Issue: unknown, P. 214340 - 214340

Published: May 1, 2025

Language: Английский

Citations

0
Dissolving PEGDA-Based Microneedles to Transdermally Deliver PDA@Cu with Photothermal Properties for Potential Antibacterial Applications DOI
Ya Gao, Hua Huo, Renyuan Zhang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(51), P. 70339 - 70351

Published: Dec. 13, 2024

The stratum corneum of the skin functions as a barrier, obstructing drug absorption and complicating treatment infections caused by pathogens such bacteria, fungi, viruses through topical methods. In this research, microneedle patch was developed, which consists gelatin-sucrose (SG) that encapsulates polydopamine-copper nanoparticles (PDA@Cu) at tip for antibacterial purposes. Poly(ethylene glycol) diacrylate (PEGDA) served primary substrate shaft (PDA@Cu-SG/PEGDA). This engineered to enhance permeability facilitate efficient delivery drugs rapid dissolution tips. Coordinate bonds can be formed between PDA Cu ions, resulting in immobilization particles on surface, aids green synthesis PDA@Cu photothermal particles. SG polymer, contained PDA@Cu, employed fill cavities series centrifugation steps. Subsequently, UV-induced polymerization carried out produce PEGDA microneedles with hydrophilic tips Furthermore, physicochemical characteristics polymer microneedles, including morphology, composition, mechanical strength, were thoroughly characterized. These demonstrated sufficient strength. Owing ability disrupt bacterial membranes, excellent vitro efficacy. We validated activity against Escherichia coli Staphylococcus aureus conducting plate coating assays. results assays indicated minimally invasive strategy achieved broad-spectrum effects; thus, may suitable approach managing polymicrobial during clinical trials.

Language: Английский

Citations

3