Collagen-Based Scaffolds for Volumetric Muscle Loss Regeneration DOI Open Access
Anna L. Luss, M. M. Bobrova, Pavel P. Kulikov

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(23), P. 3429 - 3429

Published: Dec. 6, 2024

Volumetric muscle loss (VML) is a serious problem in healthcare that requires innovative solutions. Collagen and its derivatives are promising biomaterials for tissue replacement due to their high biocompatibility, biodegradability, lack of toxicity. This review comprehensively discusses collagen from various sources, structural characteristics, cross-linking methods obtain hydrogels, approaches incorporating therapeutic molecules create biocomposite system with controlled release. Collagen-based scaffolds constructs engineering regenerative medicine. They can both perform function independently act as depot biologically active substances (drugs, growth factors, genetic material, etc.). volume restoration three-dimensional support cell adhesion proliferation provide release molecules. Various mechanical biological properties be achieved by agents bioactive incorporated into the structure. highlights recent studies on collagen-based hydrogels volumetric loss.

Language: Английский

Collagen-Based Scaffolds for Volumetric Muscle Loss Regeneration DOI Open Access
Anna L. Luss, M. M. Bobrova, Pavel P. Kulikov

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(23), P. 3429 - 3429

Published: Dec. 6, 2024

Volumetric muscle loss (VML) is a serious problem in healthcare that requires innovative solutions. Collagen and its derivatives are promising biomaterials for tissue replacement due to their high biocompatibility, biodegradability, lack of toxicity. This review comprehensively discusses collagen from various sources, structural characteristics, cross-linking methods obtain hydrogels, approaches incorporating therapeutic molecules create biocomposite system with controlled release. Collagen-based scaffolds constructs engineering regenerative medicine. They can both perform function independently act as depot biologically active substances (drugs, growth factors, genetic material, etc.). volume restoration three-dimensional support cell adhesion proliferation provide release molecules. Various mechanical biological properties be achieved by agents bioactive incorporated into the structure. highlights recent studies on collagen-based hydrogels volumetric loss.

Language: Английский

Citations

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