Coordination‐Dissociation Induced T1‐Weighted Magnetic Resonance Imaging Responses in a spn‐Type MOF for Potential Drug Release Monitoring DOI Open Access
Dan Luo, Tianze Wu, Tianze Qiu

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Abstract Developing novel nanoplatforms capable of monitoring drug release by identifiable magnetic resonance imaging (MRI) responses is a great promising yet challenging task. Here, isoreticular chemistry strategy introduced to enable spn ‐type metal–organic framework (MOF) with T 1 ‐weighted MRI turned‐on response the via coordination‐dissociation process. Post‐synthetic functionalization endows structure high longitudinal relaxivity r 12.63 m −1 s as well abundant accessible coordination sites catch carboxylate probes and drugs. Mechanism studies reveal size‐dependent decrease in coordinated increase size, bulk benzoic acid showing largest reduction at 71%. In vitro model further validate signals respectively coordinating four drugs aromatic groups. Finally, vivo experiments confirm feasibility using this coordination‐dissociation‐induced monitor release. This proof‐of‐principle study demonstrates practical pathway for designing MOF‐based responsive MRI, paving way enhanced non‐invasive techniques.

Language: Английский

Circular RNA circBNC2 inhibits tumorigenesis by modulating ferroptosis and acts as a nanotherapeutic target in prostate cancer DOI Creative Commons
Xiang Pan, Kaiwen Chen, Wei Gao

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 24, 2025

Language: Английский

Citations

0
Research progress of porous drug carriers in tumor diagnosis and therapy DOI
Li Zhu, Xinyuan Li,

Fei Yin

et al.

Macromolecular Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Language: Английский

Citations

0
Low-temperature graphitization of nickel-containing carbon xerogels facilitated by the presence of citric acid and ethylene glycol in the resorcinol-formaldehyde precursor DOI
Grigory B. Veselov, Yu. V. Shubin, Aleksey A. Vedyagin

et al.

Journal of Non-Crystalline Solids, Journal Year: 2025, Volume and Issue: 657, P. 123487 - 123487

Published: March 8, 2025

Language: Английский

Citations

0
Coordination‐Dissociation Induced T1‐Weighted Magnetic Resonance Imaging Responses in a spn‐Type MOF for Potential Drug Release Monitoring DOI Open Access
Dan Luo, Tianze Wu, Tianze Qiu

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Abstract Developing novel nanoplatforms capable of monitoring drug release by identifiable magnetic resonance imaging (MRI) responses is a great promising yet challenging task. Here, isoreticular chemistry strategy introduced to enable spn ‐type metal–organic framework (MOF) with T 1 ‐weighted MRI turned‐on response the via coordination‐dissociation process. Post‐synthetic functionalization endows structure high longitudinal relaxivity r 12.63 m −1 s as well abundant accessible coordination sites catch carboxylate probes and drugs. Mechanism studies reveal size‐dependent decrease in coordinated increase size, bulk benzoic acid showing largest reduction at 71%. In vitro model further validate signals respectively coordinating four drugs aromatic groups. Finally, vivo experiments confirm feasibility using this coordination‐dissociation‐induced monitor release. This proof‐of‐principle study demonstrates practical pathway for designing MOF‐based responsive MRI, paving way enhanced non‐invasive techniques.

Language: Английский

Citations

0