Ultrasound-activated piezoelectric biomaterials for cartilage regeneration DOI Creative Commons

Yangchen Wei,

Zhengyang Li, Tianhao Yu

et al.

Ultrasonics Sonochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 107353 - 107353

Published: April 1, 2025

Due to the low density of chondrocytes and limited ability repair damaged extracellular matrix (ECM) in cartilage, many patients with congenital or acquired craniofacial trauma require filler graft materials support facial structure, restore function, improve self-confidence, regain socialization. Ultrasound has capacity stimulate piezoelectric materials, converting mechanical energy into electrical signals that can regulate metabolism, proliferation, differentiation chondrocytes. This unique property sparked growing interest using biomaterials regenerative medicine. In this review, we first explain principle behind ultrasound-activated how they generate piezopotential. We then review studies demonstrating bioelectricity promotes chondrocyte regeneration, stimulates secretion key components supports cartilage regeneration by activating relevant signaling pathways. Next, discuss properties, synthesis, modification strategies various biomaterials. further recent progresses development specifically designed for regeneration. Lastly, future research challenges facing technology, engineering. While technology holds great promise, certain obstacles remain, including issues related material stability, precise control over ultrasound parameters, integration these systems clinical settings. The combination other emerging fields, such as Artificial Intelligence (AI) organoid chips, may open new frontiers hope encourages exploration their applications medicines.

Language: Английский

Ultrasound-activated piezoelectric biomaterials for cartilage regeneration DOI Creative Commons

Yangchen Wei,

Zhengyang Li, Tianhao Yu

et al.

Ultrasonics Sonochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 107353 - 107353

Published: April 1, 2025

Due to the low density of chondrocytes and limited ability repair damaged extracellular matrix (ECM) in cartilage, many patients with congenital or acquired craniofacial trauma require filler graft materials support facial structure, restore function, improve self-confidence, regain socialization. Ultrasound has capacity stimulate piezoelectric materials, converting mechanical energy into electrical signals that can regulate metabolism, proliferation, differentiation chondrocytes. This unique property sparked growing interest using biomaterials regenerative medicine. In this review, we first explain principle behind ultrasound-activated how they generate piezopotential. We then review studies demonstrating bioelectricity promotes chondrocyte regeneration, stimulates secretion key components supports cartilage regeneration by activating relevant signaling pathways. Next, discuss properties, synthesis, modification strategies various biomaterials. further recent progresses development specifically designed for regeneration. Lastly, future research challenges facing technology, engineering. While technology holds great promise, certain obstacles remain, including issues related material stability, precise control over ultrasound parameters, integration these systems clinical settings. The combination other emerging fields, such as Artificial Intelligence (AI) organoid chips, may open new frontiers hope encourages exploration their applications medicines.

Language: Английский

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