BMC Medicine,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Feb. 28, 2025
The
relationship
between
coronary
artery
calcium
(CAC)
and
progression
of
diastolic
dysfunction
(DD)
during
longitudinal
follow-up
is
uncertain.
This
study
aimed
to
investigate
the
prevalence
DD
according
severity
CAC
understand
their
synergistic
effect
on
mortality.
was
a
population-based
cohort
study.
All
15,193
adults
who
underwent
health
screening
exam
with
simultaneous
echocardiography
scan
were
enrolled.
Definite
(≥
3/4
abnormal
parameters
for
[e′,
E/e′,
tricuspid
regurgitation
velocity,
left
atrial
volume
index])
definite
or
probable
2/4)
defined.
All-cause
mortality
assessed
based
DD.
Among
population,
7995
participants
(52.6%)
had
=
0;
4661
(30.7%)
0
<
100;
2537
(16.7%)
≥
100.
ratios
(adjusted
ratio:
1.72,
95%
CI:
1.23–2.22)
1.83,
1.31–2.36)
significantly
higher
in
individuals
100
than
those
0.
There
significant
linear
association
E/e′
p
linearity
0.001).
Compared
without
DD,
adjusted
HRs
CI
2.56
(95%
1.67–3.94),
3.08
1.28–7.39),
3.91
1.68–9.10).
at
measurement
least
two
echocardiographic
measurements,
presence
100)
associated
accelerated
over
time
HR:
1.46,
1.13–1.88),
more
rapid
elevation
(difference:
0.06,
0.02–0.10,
0.003).
In
general
there
both
subclinical
increased
Moreover,
affects
independently
other
clinical
factors.
Journal of cardiovascular computed tomography,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 1, 2025
Low-cost/no-cost
non-contrast
CT
calcium
scoring
(CTCS)
exams
can
provide
direct
evidence
of
coronary
atherosclerosis.
In
this
study,
using
features
from
CTCS
images,
we
developed
a
novel
machine
learning
model
to
predict
obstructive
artery
disease
(CAD),
as
defined
by
the
disease-reporting
and
data
system
(CAD-RADS).
This
study
analyzed
1324
patients
SCOT-HEART
trial
who
underwent
both
angiography.
Obstructive
CAD
was
CAD-RADS
4A-5,
while
0-3
were
considered
non-obstructive
CAD.
We
clinical,
Agatston-score-derived,
epicardial
fat-omics
The
most
predictive
selected
elastic
net
logistic
regression
used
train
CatBoost
model.
Model
performance
evaluated
1000
repeated
five-fold
cross-validation
survival
analyses
major
adverse
cardiovascular
event
(MACE)
revascularization.
Generalizability
assessed
an
external
validation
set
2316
for
predictions.
Among
patients,
identified
in
334
(25.2
%).
Elastic
top
14
(5
2
7
fat-omics).
proposed
method
achieved
excellent
classifying
CAD,
with
AUC
90.1
±
0.9
%
sensitivity/specificity/accuracy
83.5
5.5
%/93.7
1.9
%/82.4
2.0
%.
inclusion
Agatston-score-derived
significantly
improved
classification
performance.
Survival
showed
that
actual
predicted
differentiated
experienced
MACE
scans.
Our
findings
highlight
potential
clinical
benefits
imaging
identifying
likely
benefit
advanced
imaging.
Expert Review of Cardiovascular Therapy,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 7
Published: Feb. 4, 2025
People
living
with
HIV
(PLHIV)
are
at
higher
risk
of
cardiovascular
disease
(CVD),
and
dyslipidemia
is
a
prevalent
comorbidity
that
requires
effective
treatment.
Limitations
for
the
use
statins
such
as
drug
interactions
adverse
effects
highlight
need
alternative
therapies.
This
review
evaluates
role
PCSK9
inhibitors
in
reducing
PLHIV
dyslipidemia.
We
analyzed
studies
available
on
PUBMED,
using
keywords
HIV,
dyslipidemia,
inhibitors,
statin
intolerance.
discuss
mechanisms
underlying
increased
risk,
limitations
statins,
including
recent
study
inhibitors.
Evolocumab
significantly
reduced
LDL-C
levels
by
56.9%
PLHIV,
72.5%
patients
achieving
≥50%
reduction.
The
trial
confirmed
drug's
safety.
Additionally,
demonstrated
reductions
lipoprotein(a)
inflammatory
markers.
PCSK9i
present
promising
option
lipid
management
especially
statin-intolerant
individuals
or
those
residual
despite
therapy.
Additional
non-statin
therapies
targeting
profiles,
low
HDL-C,
high
triglycerides,
lipoprotein(a),
under
development.
Combined
advancements
antisense
oligonucleotides
(ASOs)
siRNA
technologies,
they
hold
promise
transforming
treatment
PLHIV.
Open Heart,
Journal Year:
2025,
Volume and Issue:
12(1), P. e002791 - e002791
Published: Feb. 1, 2025
Background
Left
ventricular
(LV)
mass
is
closely
associated
with
atherosclerotic
heart
disease,
but
the
mechanisms
are
not
well
defined.
This
study
aimed
to
evaluate
risk
factors
LV
and
subclinical
coronary
atherosclerosis,
in
an
Asian
population
free
of
baseline
cardiovascular
disease.
Methods
The
SingHEART
a
population-based
cohort
which
individuals
underwent
ambulatory
blood
pressure
(BP)
monitoring,
cardiac
MRI
measure
indexed
index
(LVMI)
artery
calcium
(CAC)
scoring.
Individuals
were
stratified
based
on
LVMI
presence
CAC,
intergroup
differences
analysed.
Logistic
regression
models
used
assess
interaction
BP
prevalent
CAC.
Results
included
880
subjects
(mean
age
45.8±11.7
years,
51.4%
women).
high
had
higher
than
those
normal
LVMI.
Across
all
groups,
was
Compared
normotensive
LVMI,
no
increased
CAC
(p=0.530);
however,
progressively
hypertensive
(risk
ratio
(RR)
1.47,
95%
CI
1.13
1.91),
or
(RR
1.72,
1.26
2.36).
Conclusions
In
this
healthy
asymptomatic
population,
hypertension
strongest
factor
for
hypertrophy
modifier,
its
prognostic
significance
adults
without
requires
further
study.
Circulation Cardiovascular Imaging,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 18, 2025
BACKGROUND:
Coronary
artery
calcium
(CAC)
scoring
predicts
cardiovascular
risk,
but
social
determinants
of
health
may
play
a
role
in
its
prognostic
ability.
We
examined
whether
the
Social
Vulnerability
Index
(SVI)
modifies
association
between
CAC
and
major
adverse
events
(MACE)
community-based
screening
cohort.
METHODS:
studied
49
224
participants
without
known
disease
referred
for
scanning
from
2014
to
2022
based
on
risk
factors.
SVI
was
determined
each
participant
census
tract.
8-year
incidence
MACE
(myocardial
infarction,
stroke,
heart
failure,
revascularization,
death)
by
quartile
across
score
strata
(0,
1–99,
100–399,
≥400).
Cox
proportional
hazard
models
estimated
ratios
MACE,
associated
with
demographics,
metabolic
factors,
CAC.
RESULTS:
Higher
female
sex,
non-White
race,
greater
comorbidities,
higher
scores.
The
rate
increased
monotonically
quartile,
ratio
1.54
(95%
CI,
1.24–1.90,
P
<0.001)
highest
versus
lowest
after
adjustment.
modified
SVI,
stronger
gradient
apparent
among
vulnerable
subgroups.
CONCLUSIONS:
In
this
no-cost
cohort,
independently
predicted
outcomes
all
strata.
Focused
efforts
mitigate
incremental
vulnerability
are
needed.
BMC Medicine,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Feb. 28, 2025
The
relationship
between
coronary
artery
calcium
(CAC)
and
progression
of
diastolic
dysfunction
(DD)
during
longitudinal
follow-up
is
uncertain.
This
study
aimed
to
investigate
the
prevalence
DD
according
severity
CAC
understand
their
synergistic
effect
on
mortality.
was
a
population-based
cohort
study.
All
15,193
adults
who
underwent
health
screening
exam
with
simultaneous
echocardiography
scan
were
enrolled.
Definite
(≥
3/4
abnormal
parameters
for
[e′,
E/e′,
tricuspid
regurgitation
velocity,
left
atrial
volume
index])
definite
or
probable
2/4)
defined.
All-cause
mortality
assessed
based
DD.
Among
population,
7995
participants
(52.6%)
had
=
0;
4661
(30.7%)
0
<
100;
2537
(16.7%)
≥
100.
ratios
(adjusted
ratio:
1.72,
95%
CI:
1.23–2.22)
1.83,
1.31–2.36)
significantly
higher
in
individuals
100
than
those
0.
There
significant
linear
association
E/e′
p
linearity
0.001).
Compared
without
DD,
adjusted
HRs
CI
2.56
(95%
1.67–3.94),
3.08
1.28–7.39),
3.91
1.68–9.10).
at
measurement
least
two
echocardiographic
measurements,
presence
100)
associated
accelerated
over
time
HR:
1.46,
1.13–1.88),
more
rapid
elevation
(difference:
0.06,
0.02–0.10,
0.003).
In
general
there
both
subclinical
increased
Moreover,
affects
independently
other
clinical
factors.
