Long non-coding RNAs are involved in the crosstalk between cancer-associated fibroblasts and tumor cells DOI Creative Commons

Chenbo Yang,

Jiao Shu,

Yiwei Li

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 9, 2024

The proliferation of tumors is not merely self-regulated by the cancer cells but also intrinsically connected to tumor microenvironment (TME). Within this complex TME, cancer-associated fibroblasts (CAFs) are pivotal in modulation onset and progression. Rich signaling interactions exist between CAFs cells, which crucial for regulation. Long non-coding RNAs (LncRNAs) emerge from cellular transcription as a class functionally diverse RNA molecules. Recent studies have revealed that LncRNAs integral crosstalk with capacity modify transcriptional activity secretion profiles, thus facilitating activation, proliferation, metastasis, drug resistance, other related functionalities. This comprehensive review revisits latest research on LncRNA-mediated encapsulates biological roles LncRNAs, delves into molecular pathways broader perspective, aspiring offer novel perspectives deeper comprehension etiology enhancement therapeutic approaches.

Language: Английский

CGAM: An end-to-end causality graph attention Mamba network for esophageal pathology grading DOI
Yingbo Qu, Xiaolong Zhou, Pan Huang

et al.

Biomedical Signal Processing and Control, Journal Year: 2025, Volume and Issue: 103, P. 107452 - 107452

Published: Jan. 8, 2025

Language: Английский

Citations

3
Emerging Trends in Gastrointestinal Cancer Targeted Therapies: Harnessing Tumor Microenvironment, Immune Factors, and Metabolomics Insights DOI
Sanchita Rauth, Mokenge P. Malafa, Moorthy P. Ponnusamy

et al.

Gastroenterology, Journal Year: 2024, Volume and Issue: 167(5), P. 867 - 884

Published: May 15, 2024

Language: Английский

Citations

13
Targeting extracellular matrix interaction in gastrointestinal cancer: Immune modulation, metabolic reprogramming, and therapeutic strategies DOI

Jiyifan Li,

Wenxin Zhang, Lu Chen

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2024, Volume and Issue: unknown, P. 189225 - 189225

Published: Nov. 1, 2024

Language: Английский

Citations

4
Unveiling Another Dimension: Advanced Visualization of Cancer Invasion and Metastasis via Micro-CT Imaging DOI Open Access
Sergey Tkachev,

Vladimir Brosalov,

O. M. Kit

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(7), P. 1139 - 1139

Published: March 28, 2025

Invasion and metastasis are well-known hallmarks of cancer, with metastatic disease accounting for 60% to 90% cancer-related deaths [...].

Language: Английский

Citations

0
Long non-coding RNAs are involved in the crosstalk between cancer-associated fibroblasts and tumor cells DOI Creative Commons

Chenbo Yang,

Jiao Shu,

Yiwei Li

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 9, 2024

The proliferation of tumors is not merely self-regulated by the cancer cells but also intrinsically connected to tumor microenvironment (TME). Within this complex TME, cancer-associated fibroblasts (CAFs) are pivotal in modulation onset and progression. Rich signaling interactions exist between CAFs cells, which crucial for regulation. Long non-coding RNAs (LncRNAs) emerge from cellular transcription as a class functionally diverse RNA molecules. Recent studies have revealed that LncRNAs integral crosstalk with capacity modify transcriptional activity secretion profiles, thus facilitating activation, proliferation, metastasis, drug resistance, other related functionalities. This comprehensive review revisits latest research on LncRNA-mediated encapsulates biological roles LncRNAs, delves into molecular pathways broader perspective, aspiring offer novel perspectives deeper comprehension etiology enhancement therapeutic approaches.

Language: Английский

Citations

0