Modulating the Gut Microbiota to Combat Drug-Induced Liver Injury: A New Frontier in Hepatic Health DOI Creative Commons
Yang Ye, Huikuan Chu

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Drug-induced liver injury (DILI) encompasses a spectrum of damage caused by pharmaceuticals or their metabolites, ranging from mild, asymptomatic dysfunction to severe, acute failure. The diagnosis DILI primarily depends on thorough understanding its clinical presentation and the careful exclusion alternative etiologies injury. This chapter provides comprehensive analysis epidemiology, pathogenesis, therapeutic approaches DILI, aiming deepen this complex condition. Furthermore, it investigates emerging role gut microbiota in pathogenesis offering novel insights potential avenues for future interventions.

Language: Английский

Comparison of Pharmacokinetics of Six Bioactive Constituents from Paeoniae Radix Rubra in Normal and Toxic Heat and Blood Stasis Syndrome Rats by Uhplc-Qqq-Ms/Ms DOI

Lin-Han Xiang,

Xu-Yan Guo,

Meng-Ge Feng

et al.

Published: Jan. 1, 2025

Ethnopharmacological relevanceIn the clinical practice of traditional Chinese medicine, concept toxic heat and blood stasis syndrome (THBSS) is commonly observed in many critical diseases. Although herbal medicine Paeoniae Radix Rubra (PRR) has been employed for treating various diseases associated with THBSS, difference pharmacokinetic characteristics its bioactive constituents between such pathological state normal remains unknown.Aim studyTo elucidate profiles six from PRR following oral administration a comparative study THBSS rats.Materials methodsOne group rats was administered at dosage 12.6 g/kg, while three additional groups were dosages 6.3, 12.6, 18.9 respectively. UHPLC-QQQ-MS/MS technology utilized to conduct analysis paeoniflorin (PAE), oxypaeoniflorin (O-PAE), galloylpaeoniflorin (G-PAE), benzoylpaeoniflorin (B-PAE), salicylic acid (SA), 3,3'-di-O-methylellagic (DMA) on rat plasma samples.ResultsThe method successfully developed simultaneous determination these compounds plasma. In rats, PAE, O-PAE, G-PAE exhibit multimodal patterns relatively prolonged durations. B-PAE rapidly absorbed eliminated, mean MRT(0-t), Tmax, t1/2, CLz/F values 1.96 h, 0.42 115.37 L/h/kg, respectively, resulting short existence body. SA DMA higher bioavailability vivo exposure (mean AUC(0-t) 13604.49 39813.75 ng/mL·h) despite their low contents PRR, having lowest elimination rate (t1/2 30.74 h). Notably, behaviors G-PAE, are significantly altered (p < 0.05). The Cmax increased by 60%, 87%, 55%, AUC(0-∞) O-PAE 35%, MRT(0-∞) 36%, Tmax extended 185% 200%. Additionally, may possess linear within range other analytes do not linearity.ConclusionsThis represents inaugural investigation into pharmacokinetics rats. alterations be attributed changed flow dynamics, microvascular permeability, disorder gut microflora, or reduced drug metabolism. Furthermore, this offers valuable insights subsequent research pharmacokinetic-pharmacodynamic relationship use THBSS.

Language: Английский

Citations

1
Drug-Induced Liver Injury and the Urgent Need for Improved Diagnostic Test DOI Creative Commons
Yoshiyasu Takefuji

Medical Reports, Journal Year: 2025, Volume and Issue: unknown, P. 100170 - 100170

Published: Jan. 1, 2025

Language: Английский

Citations

0
Inulin Hydrogel Loaded with Self-Assembled Nanoparticles of Curcumin and Glycyrrhizic Acid for Inflammatory Bowel Disease Treatment Via Anti-Inflammation, Antioxidation, and Microbiota Modulation DOI
Jiaxin Wu,

Leyan Wang,

Lu Han

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Modulating the Gut Microbiota to Combat Drug-Induced Liver Injury: A New Frontier in Hepatic Health DOI Creative Commons
Yang Ye, Huikuan Chu

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Drug-induced liver injury (DILI) encompasses a spectrum of damage caused by pharmaceuticals or their metabolites, ranging from mild, asymptomatic dysfunction to severe, acute failure. The diagnosis DILI primarily depends on thorough understanding its clinical presentation and the careful exclusion alternative etiologies injury. This chapter provides comprehensive analysis epidemiology, pathogenesis, therapeutic approaches DILI, aiming deepen this complex condition. Furthermore, it investigates emerging role gut microbiota in pathogenesis offering novel insights potential avenues for future interventions.

Language: Английский

Citations

0