The Role of Genomics in Reshaping Healthcare Delivery: Personalized Medicine

The National Medical Journal of India, Journal Year: 2025, Volume and Issue: 37, P. 301 - 303

Published: April 16, 2025

Language: Английский

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Control over Imidazoquinoline Immune Stimulation by pH-Degradable Poly(norbornene) Nanogels

Biomacromolecules, Journal Year: 2020, Volume and Issue: 21(6), P. 2246 - 2257

Published: April 7, 2020

The reactivation of the innate immune system by toll-like receptor (TLR) agonists holds promise for anticancer immunotherapy. Severe side effects caused unspecific and systemic activation upon intravenous injection prevent use small-molecule TLR such purposes. However, a covalent attachment imidazoquinoline (IMDQ) TLR7/8 to pH-degradable polymeric nanogels could be shown drastically reduce inflammation but retain activity tumoral tissues their draining lymph nodes. Here, we introduce synthesis poly(norbornene)-based, acid-degradable ligation IMDQs. While intact trigger sufficient stimulation, degraded version soluble, IMDQ-conjugated poly(norbornene) chains hardly activates TLR7/8. This renders clinical safety profile, as degradation products are obtained, which would not only circumvent nanoparticle accumulation in body also provide nonactive, polymer-bound IMDQ species. Their immunologically silent behavior guarantees both spatial temporal control over and, thus, improved applications.

Language: Английский

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Post‐Polymerization Modifications to Prepare Biomedical Nanocarriers with Varying Internal Structures, their Properties and Impact on Protein Corona Formation

Macromolecular Chemistry and Physics, Journal Year: 2023, Volume and Issue: 224(24)

Published: Aug. 7, 2023

Abstract The reactive ester approach provides access to various types of drug delivery systems. Either amphiphilic block copolymer micelles with hydrophobic cores can be generated for encapsulation drugs, or they are (reversibly) crosslinked by polar molecules into nano(hydro)gel particles affording hydrophilic and coronas. Beyond short oligonucleotides complexation covalent conjugation inside the core, a surface functionalization targeting units is further possible address large variety scenarios. Interestingly, thereby not only govern nanocarriers' inner structure property, but at same time also provide strategies prevent protein corona formation. These features summarized in this article underline concept macromolecules as beneficial tool assisting delivery.

Language: Английский

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Research progress of cell membrane biomimetic nanoparticles for circulating tumor cells

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: April 30, 2024

Early detection of cancer is crucial to reducing fatalities and improving patient outcomes. Metastasis the first stage aggressive cancers, often occurring before primary lesions can be seen. It occurs when cancerous cells disseminate distant, non-malignant organs through bloodstream, known as circulating tumor (CTCs). CTCs, or cells, are valuable indicators for predicting treatment response, metastasis progression, disease progression. However, they primarily used research due challenges like heterogeneity, separation from blood, lack clinical validation. Only a few methods have been approved use. One area isolation identification which could significantly impact early prognosis. Current technologies using whole-blood samples use size, immunoaffinity, density approaches, along with positive negative enrichment techniques. Surface modification nanomaterials important effective therapies because it improves their ability target reduces interactions healthy tissues. Consequently, researchers created biomimetic nanoparticles covered cell membranes functional, targeted, biocompatible coating technology. Nanoparticles specific stay in circulation longer, avoid immune responses, makes them much better at capturing CTCs. This study examines current opportunities difficulties associated membrane–coated capture technique In addition, we examine potential future developments light obstacles investigate areas that require further fully understand its growing possibilities.

Language: Английский

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Reactive-ester derived polymer nanogels for cancer immunotherapy

European Polymer Journal, Journal Year: 2020, Volume and Issue: 124, P. 109481 - 109481

Published: Jan. 7, 2020

Language: Английский

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