Disulfide bond-driven nanoassembly of lipophilic epirubicin prodrugs for breast cancer therapy

Journal of Pharmaceutical Investigation, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Language: Английский

---

Photosensitizer-driven nanoassemblies of homodimeric prodrug for self-enhancing activation and synergistic chemo-photodynamic therapy

Theranostics, Journal Year: 2021, Volume and Issue: 11(12), P. 6019 - 6032

Published: Jan. 1, 2021

Carrier-free prodrug-nanoassemblies have emerged as promising nanomedicines. In particular, the self-assembled nanoparticles (NPs) composed of homodimeric prodrugs with ultrahigh drug loading attracted broad attention. However, most show poor self-assembly ability due to their symmetric structures. Herein, we developed photosensitizer-driven nanoassemblies prodrug for self-enhancing activation and chemo-photodynamic synergistic therapy. Methods: this work, a pyropheophorbide (PPa)-driven an oxidation-responsive cabazitaxel homodimer (CTX-S-CTX) was fabricated (pCTX-S-CTX/PPa NPs). The assembly mechanisms, aggregation-caused quenching (ACQ) effect alleviation, singlet oxygen generation, activation, cellular uptake, intracellular reactive species (ROS) generation cytotoxicity pCTX-S-CTX/PPa NPs were investigated in vitro. Moreover, pharmacokinetics, ex vivo biodistribution therapeutic efficacy studied mice bearing 4T1 tumor. Results: Interestingly, PPa found drive CTX-S-CTX, which cannot self-assemble into stable alone. Multiple intermolecular forces be involved process. Notably, nanostructure destroyed presence endogenous ROS, significantly relieving ACQ PPa. turn, ROS generated by under laser irradiation together synergistically promoted activation. As expected, demonstrated potent antitumor activity breast cancer BALB/c xenograft model. Conclusion: Our findings offer simple strategy facilitate provide efficient nanoplatform

Language: Английский

---

Erythrocyte membrane-camouflaged carrier-free nanoassembly of FRET photosensitizer pairs with high therapeutic efficiency and high security for programmed cancer synergistic phototherapy

Bioactive Materials, Journal Year: 2021, Volume and Issue: 6(8), P. 2291 - 2302

Published: Jan. 23, 2021

Phototherapy has been intensively investigated as a non-invasive cancer treatment option. However, its clinical translation is still impeded by unsatisfactory therapeutic efficacy and severe phototoxicity. To achieve high efficiency security, nanoassembly of Forster Resonance Energy Transfer (FRET) photosensitizer pairs developed on basis dual-mode co-loading photocaging strategy. For proof-of-concept, an erythrocyte-camouflaged FRET pair co-assembly chlorine e6 (Ce6, donor) 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindotricarbocyanine iodide (DiR, acceptor) for breast treatment. Notably, Ce6 in the nanoassemby quenched DiR could be unlocked photodynamic therapy (PDT) only when photobleached 808-nm laser. As result, Ce6-caused phototoxicity well controlled. Under cascaded laser irradiation (808–660 nm), tumor-localizing temperature rise following not induces tumor cell apoptosis but also facilitates penetration NPs, relieves hypoxia, promotes PDT Ce6. Such pair-based provides new strategy developing multimodal phototherapy nanomedicines with good security.

Language: Английский

---

Small changes in the length of diselenide bond-containing linkages exert great influences on the antitumor activity of docetaxel homodimeric prodrug nanoassemblies

Asian Journal of Pharmaceutical Sciences, Journal Year: 2021, Volume and Issue: 16(3), P. 337 - 349

Published: Feb. 25, 2021

Homodimeric prodrug-based self-assembled nanoparticles, with carrier-free structure and ultrahigh drug loading, is drawing more attentions. prodrugs are composed of two molecules a pivotal linkage. The influence the linkages on self-assembly, in vivo fate antitumor activity homodimeric focus research. Herein, three docetaxel (DTX) developed using different lengths diselenide bond-containing linkages. Interestingly, compared other linkages, longest linkage could facilitate self-delivery DTX prodrugs, thus improving stability, circulation time tumor targeting prodrug nanoassemblies. Besides, extension reduces redox-triggered release cytotoxicity nanoassemblies cells. Although possessed lowest to 4T1 cells, their stable nanostructure maintained intact during achieve maximum accumulation which finally "turned table". Our study illustrates crucial role gives valuable proposal for development advanced nano-DDS cancer treatment.

Language: Английский

---

Precisely engineering a dual-drug cooperative nanoassembly for proteasome inhibition-potentiated photodynamic therapy

Chinese Chemical Letters, Journal Year: 2021, Volume and Issue: 33(4), P. 1927 - 1932

Published: Nov. 24, 2021

Language: Английский

---