Pharmaceutics,
Journal Year:
2021,
Volume and Issue:
13(2), P. 155 - 155
Published: Jan. 25, 2021
Nanotechnology
platforms,
such
as
nanoparticles,
liposomes,
dendrimers,
and
micelles
have
been
studied
extensively
for
various
drug
deliveries,
to
treat
or
prevent
diseases
by
modulating
physiological
pathological
processes.
The
delivery
molecules
range
from
traditional
small
recently
developed
biologics,
proteins,
peptides,
nucleic
acids.
Among
them,
proteins
shown
a
series
of
advantages
potential
in
therapeutic
applications,
introducing
due
genetic
defects,
used
nanocarriers
anticancer
agents
decelerate
tumor
growth
control
metastasis.
This
review
discusses
the
existing
nanoparticle
systems,
design
strategies,
using
each
system,
possible
limitations.
Moreover,
we
will
examine
intracellular
different
protein
therapeutics,
antibodies,
antigens,
gene
editing
into
host
cells
achieve
effects
cancer
vaccines.
Finally,
explore
current
applications
treatments.
Nano Letters,
Journal Year:
2023,
Volume and Issue:
23(4), P. 1219 - 1228
Published: Feb. 2, 2023
Due
to
the
complexity
and
heterogeneity
in
tumor
microenvironment,
efficacy
of
breast
cancer
treatment
has
been
significantly
impeded.
Here,
we
established
a
living
system
using
an
engineered
M13
bacteriophage
through
chemical
cross-linking
biomineralization
remodel
microenvironment.
Chemically
gel
(M13
Gel)
could
situ
synthesize
photothermal
palladium
nanoparticles
(PdNPs)
on
pVIII
capsid
protein
obtain
M13@Pd
Gel.
In
addition,
NLG919
was
further
loaded
into
form
(M13@Pd/NLG
gel)
for
down-regulating
expression
tryptophan
metabolic
enzyme
indoleamine
2,3-dioxygenase
1
(IDO1).
Both
vitro
vivo
studies
showed
that
served
not
only
as
cargo-loaded
device
but
also
self-immune
adjuvant,
which
induced
immunogenic
death
cells
effectively
down-regulated
IDO1
expression.
Such
bioactive
constructed
by
natural
materials
reverse
immunosuppression
improve
anti-breast
response.
Journal of Medicinal Chemistry,
Journal Year:
2023,
Volume and Issue:
66(11), P. 7268 - 7279
Published: May 23, 2023
To
integrate
targeted
diagnosis
and
treatment
of
cancer,
we
proposed
to
develop
a
gadolinium
(Gd)
agent
based
on
the
properties
apoferritin
(AFt).
this
end,
not
only
optimized
series
Gd(III)
8-hydroxyquinoline-2-carboxaldehyde-thiosemicarbazone
compounds
obtain
compound
(C4)
with
remarkable
T1-weighted
magnetic
resonance
imaging
(MRI)
performance
cytotoxicity
cancer
cells
in
vitro
but
also
constructed
an
AFt–C4
nanoparticle
(NP)
delivery
system.
Importantly,
NPs
improved
targeting
ability
C4
vivo
showed
enhanced
MRI
tumor
growth
inhibition
ratio
relative
alone.
Furthermore,
confirmed
that
inhibited
through
apoptosis,
ferroptosis,
ferroptosis-induced
immune
response.
Pharmaceutics,
Journal Year:
2021,
Volume and Issue:
13(2), P. 155 - 155
Published: Jan. 25, 2021
Nanotechnology
platforms,
such
as
nanoparticles,
liposomes,
dendrimers,
and
micelles
have
been
studied
extensively
for
various
drug
deliveries,
to
treat
or
prevent
diseases
by
modulating
physiological
pathological
processes.
The
delivery
molecules
range
from
traditional
small
recently
developed
biologics,
proteins,
peptides,
nucleic
acids.
Among
them,
proteins
shown
a
series
of
advantages
potential
in
therapeutic
applications,
introducing
due
genetic
defects,
used
nanocarriers
anticancer
agents
decelerate
tumor
growth
control
metastasis.
This
review
discusses
the
existing
nanoparticle
systems,
design
strategies,
using
each
system,
possible
limitations.
Moreover,
we
will
examine
intracellular
different
protein
therapeutics,
antibodies,
antigens,
gene
editing
into
host
cells
achieve
effects
cancer
vaccines.
Finally,
explore
current
applications
treatments.
