Advanced Materials,
Journal Year:
2021,
Volume and Issue:
34(1)
Published: Oct. 14, 2021
Abstract
Cancer
vaccines
aim
at
eliciting
tumor‐specific
responses
for
the
immune
system
to
identify
and
eradicate
malignant
tumor
cells
while
sparing
normal
tissues.
Furthermore,
cancer
can
potentially
induce
long‐term
immunological
memory
antitumor
responses,
preventing
metastasis
recurrence,
thus
presenting
an
attractive
treatment
option
in
immunotherapy.
However,
clinical
efficacy
of
has
remained
low
due
longstanding
challenges,
such
as
poor
immunogenicity,
immunosuppressive
microenvironment,
heterogeneity,
inappropriate
tolerance,
systemic
toxicity.
Recently,
bioinspired
materials
biomimetic
technologies
have
emerged
play
a
part
reshaping
field
nanomedicine.
By
mimicking
desirable
chemical
biological
properties
nature,
engineering
vaccine
delivery
platforms
effectively
transport
therapeutic
cargos
sites,
amplify
antigen
adjuvant
bioactivities,
enable
spatiotemporal
control
on‐demand
immunoactivation.
As
such,
integration
designs
into
enhance
retaining
good
safety
profiles,
which
contributes
expediting
translation
vaccines.
Recent
advances
vaccines,
existing
obstacles
faced,
well
insights
future
directions
are
discussed
here.
Applied Physics Reviews,
Journal Year:
2022,
Volume and Issue:
9(1)
Published: March 1, 2022
In
recent
years,
the
role
of
optically
sensitive
nanomaterials
has
become
powerful
moieties
in
therapeutic
techniques
and
particularly
emphasized.
Currently,
by
extraordinary
development
different
fields
medicine,
they
have
found
new
applications.
Phototherapy
modalities,
such
as
photothermal
therapy
(PTT)
toxic
heat
generation
photodynamic
(PDT)
reactive
oxygen
species,
are
known
promising
phototherapeutic
techniques,
which
can
overcome
limitations
conventional
protocols.
Moreover,
nanomaterial-based
PDT
PTT
match
simultaneous
immune
increase
system
stimulation
resulting
from
denaturation
cancer
cells.
Nevertheless,
should
sufficient
biocompatibility
efficiency
to
meet
requirements
agents.
The
present
review
focuses
on
potency
PDT,
PTT,
also
their
combined
alternative
protocols
with
minimal
morbidity
integrated
into
gold
standard
treatments
surgery,
chemotherapy,
radiation
at
tumor
treatment
cancer-related
infectious
diseases.
addition,
for
deeper
understanding,
photoablation
effects
emphasis
nature,
morphology,
size
photosensitive
were
studied.
Finally,
transportation
needed
carriers
photosensitizers
agents
hard-accessed
regions,
example,
cancerous
investigated.
Materials Today,
Journal Year:
2023,
Volume and Issue:
63, P. 239 - 287
Published: Jan. 12, 2023
Dissolving
microneedles
(dMNs)
are
promising
versatile
drug
delivery
systems
for
the
transdermal
of
numerous
drugs,
enabling
their
use
in
a
wide
range
biomedical
and
pharmaceutical
applications.
Being
made
water-soluble
polymers,
dMNs
own
several
advantages,
including
fast
dissolution
short
application
time
which
enhance
patients'
compliance
minimize
damage
to
skin
tissue.
Moreover,
they
possess
no
biohazard
risk
as
leave
sharp
waste
behind.
For
these
reasons,
research
on
has
increased
dramatically
recent
years.
The
formulation
successful
requires
well-defined
pre-set
design,
considering
goal
payloads
that
will
be
used.
Every
aspect
patch
needles
geometry,
polymer
composition,
method
formation
payloads,
direct
effect
mechanical
properties
MNs,
affecting
administration
efficacy.
Thus,
there
is
need
understand
how
each
factor
affects
final
optimize
MN.
Taking
this
into
consideration,
review
serves
guide
dMN
formulation,
discussing
different
setbacks
step
possible
strategies
overcome
them,
improving
administration,
enhancing
loading
various
molecules
controlled
release.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(1), P. 277 - 277
Published: Jan. 13, 2023
Transdermal
delivery
provides
numerous
benefits
over
conventional
routes
of
administration.
However,
this
strategy
is
generally
limited
to
a
few
molecules
with
specific
physicochemical
properties
(low
molecular
weight,
high
potency,
and
moderate
lipophilicity)
due
the
barrier
function
stratum
corneum
layer.
Researchers
have
developed
several
physical
enhancement
techniques
expand
applications
transdermal
field;
among
these,
microneedle
technology
has
recently
emerged
as
promising
platform
deliver
therapeutic
agents
any
size
into
across
skin.
Typically,
hydrophilic
biomolecules
cannot
penetrate
skin
by
passive
diffusion.
Microneedle
insertion
disrupts
integrity
compromises
its
protective
function,
thus
creating
pathways
(microchannels)
for
enhanced
permeation
macromolecules.
Microneedles
not
only
improve
stability
but
also
enhance
various
biomolecules.
Academic
institutions
industrial
companies
invested
substantial
resources
in
development
systems
biopharmaceutical
delivery.
This
review
article
summarizes
most
recent
research
provide
comprehensive
discussion
about
microneedle-mediated
macromolecules,
covering
topics
from
introduction
skin,
delivery,
microneedles,
biopharmaceuticals
(current
status,
administration,
issues),
different
types,
clinical
trials,
safety
acceptability
manufacturing
regulatory
issues,
future
technology.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Jan. 13, 2024
Abstract
Transdermal
drug
delivery
is
of
vital
importance
for
medical
treatments.
However,
user
adherence
to
long-term
repetitive
poses
a
grand
challenge.
Furthermore,
the
dynamic
and
unpredictable
disease
progression
demands
pharmaceutical
treatment
that
can
be
actively
controlled
in
real-time
ensure
precision
personalization.
Here,
we
report
spatiotemporal
on-demand
patch
(SOP)
integrates
drug-loaded
microneedles
with
biocompatible
metallic
membranes
enable
electrically
triggered
active
control
release.
Precise
release
targeted
locations
(<1
mm
2
),
rapid
response
electrical
triggers
(<30
s),
multi-modal
operation
involving
both
stimulation
highlight
novelty.
Solution-based
fabrication
ensures
high
customizability
scalability
tailor
SOP
various
needs.
The
wireless-powered
digital-controlled
demonstrates
great
promise
achieving
full
automation
delivery,
improving
while
ensuring
precision.
Based
on
these
characteristics,
utilized
SOPs
sleep
studies.
We
revealed
programmed
exogenous
melatonin
from
improve
mice,
indicating
potential
values
basic
research
clinical
