Development of Nanocarrier-Based Radionuclide and Photothermal Therapy in Combination with Chemotherapy in Melanoma Cancer Treatment

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(10), P. 13460 - 13471

Published: March 3, 2023

Conventional cancer therapy methods have serious drawbacks that are related to the nonspecific action of anticancer drugs leads high toxicity on normal cells and increases risk recurrence. The therapeutic effect can be significantly enhanced when various treatment modalities implemented. Here, we demonstrate radio- photothermal (PTT) delivered through nanocarriers (gold nanorods, Au NRs) in combination with chemotherapy a melanoma results complete tumor inhibition compared single therapy. synthesized effectively labeled 188Re radionuclide radiolabeling efficiency (94-98%) radiochemical stability (>95%) appropriate for Further, 188Re-Au NRs, mediating conversion laser radiation into heat, were intratumorally injected PTT was applied. Upon irradiation near-infrared laser, dual achieved. Additionally, 188Re-labeled NRs paclitaxel (PTX) has improved (188Re-labeled irradiation, PTX) monoregime. Thus, this local triple-combination step toward clinical translation use treatment.

Language: Английский

---

Encapsulation of a small-molecule drug based on substituted 2-aminothiophenes in calcium carbonate carriers for therapy of melanoma

Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(13), P. 3431 - 3445

Published: Jan. 1, 2024

Encapsulation of 2-aminothiophenes in calcium carbonate particles leads to improved antitumor activity against melanoma.

Language: Английский

---

Recent advances in the development of 225Ac- and 211At-labeled radioligands for radiotheranostics

Analytical Sciences, Journal Year: 2024, Volume and Issue: 40(5), P. 803 - 826

Published: April 2, 2024

Abstract Radiotheranostics utilizes a set of radioligands incorporating diagnostic or therapeutic radionuclides to achieve both diagnosis and therapy. Imaging probes using have been used for systemic cancer imaging. Integration into the imaging serves as potent agents radionuclide Among them, targeted alpha therapy (TAT) is promising next-generation The α-particles emitted by in TAT result high linear energy transfer over short range, inducing substantial damage nearby cells surrounding binding site. Therefore, key successful treatment with minimal side effects depends on selective delivery their targets. Recently, targeting biomolecules highly expressed various cells, such sodium/iodide symporter, norepinephrine transporter, somatostatin receptor, α v β 3 integrin, prostate-specific membrane antigen, fibroblast-activation protein, human epidermal growth factor receptor 2 developed made remarkable progress toward clinical application. In this review, we focus two radionuclides, 225 Ac 211 At, which are expected wide range applications TAT. We also introduce recent fundamental studies radiopharmaceuticals labeled these radionuclides. Graphical abstract

Language: Английский

---

Novel bio-carriers for radionuclide delivery in cancer radiotherapy

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 533, P. 216557 - 216557

Published: Feb. 26, 2025

Language: Английский

---

Calcium carbonate carriers for combined chemo- and radionuclide therapy of metastatic lung cancer

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 344, P. 1 - 11

Published: Feb. 16, 2022

Language: Английский

---

Polyelectrolyte Multilayered Capsules as Biomedical Tools

Polymers, Journal Year: 2022, Volume and Issue: 14(3), P. 479 - 479

Published: Jan. 25, 2022

Polyelectrolyte multilayered capsules (PEMUCs) obtained using the Layer-by-Layer (LbL) method have become powerful tools for different biomedical applications, which include drug delivery, theranosis or biosensing. However, exploitation of PEMUCs in field requires a deep understanding most fundamental bases underlying their assembly processes, and control properties to fabricate novel materials with optimized ability specific targeting therapeutic capacity. This review presents an updated perspective on multiple avenues opened application field, aiming highlight some important advantages offered by LbL fabrication platforms use detection treatment diseases.

Language: Английский

---

Universal Chelator-Free Radiolabeling of Organic and Inorganic-Based Nanocarriers with Diagnostic and Therapeutic Isotopes for Internal Radiotherapy

Chemistry of Materials, Journal Year: 2022, Volume and Issue: 34(14), P. 6593 - 6605

Published: July 8, 2022

Biomedical application of various nanoparticles (NPs) for bioimaging and therapeutic purposes attracts huge interest. In particular, NPs can be used as nanocarriers radionuclides radiotherapy malignant neoplasms. However, most approaches NP radiolabeling are complicated, their transfer into clinical practice is difficult due to multistep process, limited reproducibility, lack an automated procedure. Here, we develop a universal method suitable (either organic or inorganic) internal B16-F10 melanoma tumors. The obtained (polylactide, silica, gold, iron oxide) were labeled with diagnostic (99mTc) (188Re) high efficiency (∼94–98%) radiochemical stability (>95%). After intratumoral administration, these 188Re-labeled mostly remained in the tumor, inhibiting tumor growth rate compared untreated absence any significant leakage radiolabeled healthy tissues (the liver, heart, kidneys, lungs, spleen) was confirmed by single-photon emission computed tomography (SPECT) direct radiometry analysis. Histological analysis revealed no abnormal changes organs after therapy (e.g., acute pathologic findings detected liver kidneys). As result, treatment mice led prolonged survival control group. Thus, our study provides general guidance use different types radionuclide therapy.

Language: Английский

---

Targeted Alpha Therapy: All We Need to Know about 225Ac’s Physical Characteristics and Production as a Potential Theranostic Radionuclide

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(12), P. 1679 - 1679

Published: Dec. 2, 2023

The high energy of α emitters, and the strong linear transfer that goes along with it, lead to very efficient cell killing through DNA damage. Moreover, degree oxygenation cycle state have no impact on these effects. Therefore, radioisotopes can offer a treatment choice individuals who are not responding β- or gamma-radiation therapy chemotherapy drugs. Only few α-particle emitters suitable for targeted alpha (TAT) clinical applications. majority available research involves 225Ac its daughter nuclide 213Bi. Additionally, disintegration cascade generates γ decays be used in single-photon emission computed tomography (SPECT) imaging, expanding potential theranostic applications nuclear medicine. Despite growing interest applying 225Ac, restricted global accessibility this radioisotope makes it difficult conduct extensive trials many radiopharmaceutical candidates. To boost availability applications, review attempts highlight fundamental physical properties α-particle-emitting isotope, as well existing possible production methods.

Language: Английский

---

Calcium Carbonate Core–Shell Particles for Incorporation of ²²⁵Ac and Their Application in Local α-Radionuclide Therapy

ACS Applied Materials & Interfaces, Journal Year: 2021, Volume and Issue: 13(22), P. 25599 - 25610

Published: May 24, 2021

Actinium-225 (225Ac) radiolabeled submicrometric core-shell particles (SPs) made of calcium carbonate (CaCO3) coated with biocompatible polymers [tannic acid-human serum albumin (TA/HSA)] have been developed to improve the efficiency local α-radionuclide therapy in melanoma models (B16-F10 tumor-bearing mice). The 225Ac-SPs possess radiochemical stability and demonstrate effective retention 225Ac its daughter isotopes. SPs additionally labeled zirconium-89 (89Zr) perform biodistribution studies using positron emission tomography-computerized tomography (PET/CT) imaging for 14 days after intratumoral injection. According PET/CT analysis, a significant accumulation 89Zr-SPs tumor area is revealed whole investigation period, which correlates direct radiometry analysis administration 225Ac-SPs. histological has no abnormal changes healthy tissue organs treatment (e.g., acute pathologic findings are detected liver kidneys). At same time, inhibition growth observed as compared control samples [nonradiolabeled phosphate-buffered saline (PBS)]. mice resulted prolonged survival samples. Thus, our study validates application 225Ac-doped submicron CaCO3 therapy.

Language: Английский

---

Functionalized Calcium Carbonate–Based Microparticles as a Versatile Tool for Targeted Cancer Treatment

Published: April 3, 2024

Nano- and microparticles are increasingly widely used in biomedical research applications, particularly as specific labels targeted delivery vehicles. Silica has long been considered the best material for such vehicles, but it some disadvantages limiting its potential, proneness of silica-based carriers to spontaneous drug release. Calcium carbonate (CaCO3) is an emerging alternative, being easily available, cost-effective, biocompatible with high porosity surface reactivity, which makes attractive choice delivery. CaCO3 particles this field form either bare microbeads or core/shell representing polymer-coated cores. In addition, they serve removable templates obtaining hollow polymer microcapsules. Each these types advantages terms applications. primarily due their capacity carrying pharmaceutics, whereas systems ensure better protection drug-loaded core from environment. Hollow capsules because can encapsulate large amounts pharmaceutical agents be so designed release contents target site response stimuli. This review focuses first on chemistry cores, microbeads, Then, using structures therapeutic agents, including drugs, proteins, DNA, outlined. The results systematic analysis available data presented. They show that encapsulation various CaCO3-based microcapsules a promising technique delivery, especially cancer therapy, enhancing bioavailability targeting cells while reducing side effects. To date, assembled mainly dealt properties vitro, vivo behavior still remains poorly studied. However, enormous potential highly applications undoubted. last issue addressed depth Conclusion Outlook sections review.

Language: Английский

---