Chimica Techno Acta,
Journal Year:
2024,
Volume and Issue:
11(2)
Published: May 21, 2024
Nanoparticles
(NPs)
are
widely
used
platforms
for
delivery
of
various
biologically
active
compounds.
Unfortunately,
there
is
a
lack
comprehensive
investigations
that
would
include
few
types
NPs
with
different
physicochemical
parameters
and
their
potential
use
as
systems
in
one
tumor
model.
Therefore,
to
achieve
therapeutic
effect
via
nanocarrier
agent,
the
properties
developed
must
be
clearly
defined.
Herein,
we
report
development
modification
99mTc
Cy5-labeled
based
on
calcium
carbonate
(CaCO3)
silica
oxide
(SiO2)
investigate
vitro
vivo
distribution
an
example
breast
cancer
We
describe
synthesis
characterization
these
NPs,
including
morphology,
size
distribution,
stability
biological
media
cytotoxicity.
Transmission
electron
microscopy
(TEM),
confocal
laser
scanning
(CLSM),
dynamic
light
scattering
(DLS),
Fourier
transform
infrared
spectroscopy
(FTIR),
direct
radiometry
analysis,
histology
were
collect
all
data.
The
cellular
uptake
4T1
cell
linewas
shown
vivo.
As
result,
demonstrated
non-toxic,
biocompatible,
stable
system
bioactive
compounds
into
cancer.
ACS Applied Materials & Interfaces,
Journal Year:
2023,
Volume and Issue:
15(10), P. 13460 - 13471
Published: March 3, 2023
Conventional
cancer
therapy
methods
have
serious
drawbacks
that
are
related
to
the
nonspecific
action
of
anticancer
drugs
leads
high
toxicity
on
normal
cells
and
increases
risk
recurrence.
The
therapeutic
effect
can
be
significantly
enhanced
when
various
treatment
modalities
implemented.
Here,
we
demonstrate
radio-
photothermal
(PTT)
delivered
through
nanocarriers
(gold
nanorods,
Au
NRs)
in
combination
with
chemotherapy
a
melanoma
results
complete
tumor
inhibition
compared
single
therapy.
synthesized
effectively
labeled
188Re
radionuclide
radiolabeling
efficiency
(94-98%)
radiochemical
stability
(>95%)
appropriate
for
Further,
188Re-Au
NRs,
mediating
conversion
laser
radiation
into
heat,
were
intratumorally
injected
PTT
was
applied.
Upon
irradiation
near-infrared
laser,
dual
achieved.
Additionally,
188Re-labeled
NRs
paclitaxel
(PTX)
has
improved
(188Re-labeled
irradiation,
PTX)
monoregime.
Thus,
this
local
triple-combination
step
toward
clinical
translation
use
treatment.
Analytical Sciences,
Journal Year:
2024,
Volume and Issue:
40(5), P. 803 - 826
Published: April 2, 2024
Abstract
Radiotheranostics
utilizes
a
set
of
radioligands
incorporating
diagnostic
or
therapeutic
radionuclides
to
achieve
both
diagnosis
and
therapy.
Imaging
probes
using
have
been
used
for
systemic
cancer
imaging.
Integration
into
the
imaging
serves
as
potent
agents
radionuclide
Among
them,
targeted
alpha
therapy
(TAT)
is
promising
next-generation
The
α-particles
emitted
by
in
TAT
result
high
linear
energy
transfer
over
short
range,
inducing
substantial
damage
nearby
cells
surrounding
binding
site.
Therefore,
key
successful
treatment
with
minimal
side
effects
depends
on
selective
delivery
their
targets.
Recently,
targeting
biomolecules
highly
expressed
various
cells,
such
sodium/iodide
symporter,
norepinephrine
transporter,
somatostatin
receptor,
α
v
β
3
integrin,
prostate-specific
membrane
antigen,
fibroblast-activation
protein,
human
epidermal
growth
factor
receptor
2
developed
made
remarkable
progress
toward
clinical
application.
In
this
review,
we
focus
two
radionuclides,
225
Ac
211
At,
which
are
expected
wide
range
applications
TAT.
We
also
introduce
recent
fundamental
studies
radiopharmaceuticals
labeled
these
radionuclides.
Graphical
abstract
Polymers,
Journal Year:
2022,
Volume and Issue:
14(3), P. 479 - 479
Published: Jan. 25, 2022
Polyelectrolyte
multilayered
capsules
(PEMUCs)
obtained
using
the
Layer-by-Layer
(LbL)
method
have
become
powerful
tools
for
different
biomedical
applications,
which
include
drug
delivery,
theranosis
or
biosensing.
However,
exploitation
of
PEMUCs
in
field
requires
a
deep
understanding
most
fundamental
bases
underlying
their
assembly
processes,
and
control
properties
to
fabricate
novel
materials
with
optimized
ability
specific
targeting
therapeutic
capacity.
This
review
presents
an
updated
perspective
on
multiple
avenues
opened
application
field,
aiming
highlight
some
important
advantages
offered
by
LbL
fabrication
platforms
use
detection
treatment
diseases.
Chemistry of Materials,
Journal Year:
2022,
Volume and Issue:
34(14), P. 6593 - 6605
Published: July 8, 2022
Biomedical
application
of
various
nanoparticles
(NPs)
for
bioimaging
and
therapeutic
purposes
attracts
huge
interest.
In
particular,
NPs
can
be
used
as
nanocarriers
radionuclides
radiotherapy
malignant
neoplasms.
However,
most
approaches
NP
radiolabeling
are
complicated,
their
transfer
into
clinical
practice
is
difficult
due
to
multistep
process,
limited
reproducibility,
lack
an
automated
procedure.
Here,
we
develop
a
universal
method
suitable
(either
organic
or
inorganic)
internal
B16-F10
melanoma
tumors.
The
obtained
(polylactide,
silica,
gold,
iron
oxide)
were
labeled
with
diagnostic
(99mTc)
(188Re)
high
efficiency
(∼94–98%)
radiochemical
stability
(>95%).
After
intratumoral
administration,
these
188Re-labeled
mostly
remained
in
the
tumor,
inhibiting
tumor
growth
rate
compared
untreated
absence
any
significant
leakage
radiolabeled
healthy
tissues
(the
liver,
heart,
kidneys,
lungs,
spleen)
was
confirmed
by
single-photon
emission
computed
tomography
(SPECT)
direct
radiometry
analysis.
Histological
analysis
revealed
no
abnormal
changes
organs
after
therapy
(e.g.,
acute
pathologic
findings
detected
liver
kidneys).
As
result,
treatment
mice
led
prolonged
survival
control
group.
Thus,
our
study
provides
general
guidance
use
different
types
radionuclide
therapy.
Pharmaceuticals,
Journal Year:
2023,
Volume and Issue:
16(12), P. 1679 - 1679
Published: Dec. 2, 2023
The
high
energy
of
α
emitters,
and
the
strong
linear
transfer
that
goes
along
with
it,
lead
to
very
efficient
cell
killing
through
DNA
damage.
Moreover,
degree
oxygenation
cycle
state
have
no
impact
on
these
effects.
Therefore,
radioisotopes
can
offer
a
treatment
choice
individuals
who
are
not
responding
β-
or
gamma-radiation
therapy
chemotherapy
drugs.
Only
few
α-particle
emitters
suitable
for
targeted
alpha
(TAT)
clinical
applications.
majority
available
research
involves
225Ac
its
daughter
nuclide
213Bi.
Additionally,
disintegration
cascade
generates
γ
decays
be
used
in
single-photon
emission
computed
tomography
(SPECT)
imaging,
expanding
potential
theranostic
applications
nuclear
medicine.
Despite
growing
interest
applying
225Ac,
restricted
global
accessibility
this
radioisotope
makes
it
difficult
conduct
extensive
trials
many
radiopharmaceutical
candidates.
To
boost
availability
applications,
review
attempts
highlight
fundamental
physical
properties
α-particle-emitting
isotope,
as
well
existing
possible
production
methods.
ACS Applied Materials & Interfaces,
Journal Year:
2021,
Volume and Issue:
13(22), P. 25599 - 25610
Published: May 24, 2021
Actinium-225
(225Ac)
radiolabeled
submicrometric
core-shell
particles
(SPs)
made
of
calcium
carbonate
(CaCO3)
coated
with
biocompatible
polymers
[tannic
acid-human
serum
albumin
(TA/HSA)]
have
been
developed
to
improve
the
efficiency
local
α-radionuclide
therapy
in
melanoma
models
(B16-F10
tumor-bearing
mice).
The
225Ac-SPs
possess
radiochemical
stability
and
demonstrate
effective
retention
225Ac
its
daughter
isotopes.
SPs
additionally
labeled
zirconium-89
(89Zr)
perform
biodistribution
studies
using
positron
emission
tomography-computerized
tomography
(PET/CT)
imaging
for
14
days
after
intratumoral
injection.
According
PET/CT
analysis,
a
significant
accumulation
89Zr-SPs
tumor
area
is
revealed
whole
investigation
period,
which
correlates
direct
radiometry
analysis
administration
225Ac-SPs.
histological
has
no
abnormal
changes
healthy
tissue
organs
treatment
(e.g.,
acute
pathologic
findings
are
detected
liver
kidneys).
At
same
time,
inhibition
growth
observed
as
compared
control
samples
[nonradiolabeled
phosphate-buffered
saline
(PBS)].
mice
resulted
prolonged
survival
samples.
Thus,
our
study
validates
application
225Ac-doped
submicron
CaCO3
therapy.
Nano-
and
microparticles
are
increasingly
widely
used
in
biomedical
research
applications,
particularly
as
specific
labels
targeted
delivery
vehicles.
Silica
has
long
been
considered
the
best
material
for
such
vehicles,
but
it
some
disadvantages
limiting
its
potential,
proneness
of
silica-based
carriers
to
spontaneous
drug
release.
Calcium
carbonate
(CaCO3)
is
an
emerging
alternative,
being
easily
available,
cost-effective,
biocompatible
with
high
porosity
surface
reactivity,
which
makes
attractive
choice
delivery.
CaCO3
particles
this
field
form
either
bare
microbeads
or
core/shell
representing
polymer-coated
cores.
In
addition,
they
serve
removable
templates
obtaining
hollow
polymer
microcapsules.
Each
these
types
advantages
terms
applications.
primarily
due
their
capacity
carrying
pharmaceutics,
whereas
systems
ensure
better
protection
drug-loaded
core
from
environment.
Hollow
capsules
because
can
encapsulate
large
amounts
pharmaceutical
agents
be
so
designed
release
contents
target
site
response
stimuli.
This
review
focuses
first
on
chemistry
cores,
microbeads,
Then,
using
structures
therapeutic
agents,
including
drugs,
proteins,
DNA,
outlined.
The
results
systematic
analysis
available
data
presented.
They
show
that
encapsulation
various
CaCO3-based
microcapsules
a
promising
technique
delivery,
especially
cancer
therapy,
enhancing
bioavailability
targeting
cells
while
reducing
side
effects.
To
date,
assembled
mainly
dealt
properties
vitro,
vivo
behavior
still
remains
poorly
studied.
However,
enormous
potential
highly
applications
undoubted.
last
issue
addressed
depth
Conclusion
Outlook
sections
review.