Recent Advances of Composite Nanomaterials for Antibiofilm Application DOI Creative Commons
Ruilian Qi, Yuanyuan Cui, Jian Liu

et al.

Nanomaterials, Journal Year: 2023, Volume and Issue: 13(19), P. 2725 - 2725

Published: Oct. 8, 2023

A biofilm is a microbial community formed by bacteria that adsorb on the surface of tissues or materials and wrapped in extracellular polymeric substances (EPS) such as polysaccharides, proteins nucleic acids. As protective barrier, EPS can not only prevent penetration antibiotics other antibacterial agents into biofilm, but also protect from attacks human immune system, making it difficult to eradicate biofilm-related infections posing serious threat public health. Therefore, there an urgent need develop new efficient antibiofilm drugs. Although natural enzymes (lysozyme, peroxidase, etc.) antimicrobial peptides have excellent bactericidal activity, their low stability physiological environment poor permeability biofilms limit application antibiofilms. With development science, more nanomaterials are being designed be utilized for applications. Nanomaterials great prospects because good biocompati-bility, unique physical chemical properties, adjustable nanostructure, high non-proneness induce bacterial resistance. In this review, with composite antibiofilms theme, we summarize research progress three types nanomaterials, including organic materials, inorganic organic–inorganic hybrid used non-phototherapy phototherapy modes action. At same time, challenges directions these therapy discussed. It expected will provide ideas design safe materials.

Language: Английский

Understanding bacterial biofilms: From definition to treatment strategies DOI Creative Commons
Ailing Zhao,

Jiazheng Sun,

Yipin Liu

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13

Published: April 6, 2023

Bacterial biofilms are complex microbial communities encased in extracellular polymeric substances. Their formation is a multi-step process. Biofilms significant problem treating bacterial infections and one of the main reasons for persistence infections. They can exhibit increased resistance to classical antibiotics cause disease through device-related non-device (tissue) -associated infections, posing severe threat global health issues. Therefore, early detection search new alternative treatments essential suppressing biofilm-associated In this paper, we systematically reviewed biofilms, associated methods, potential treatment strategies, aiming provide researchers with latest progress biofilms.

Language: Английский

Citations

214
Designing Single‐Atom Active Sites on sp2‐Carbon Linked Covalent Organic Frameworks to Induce Bacterial Ferroptosis‐Like for Robust Anti‐Infection Therapy DOI Creative Commons
Baohong Sun, Xinye Wang,

Ziqiu Ye

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(13)

Published: Feb. 27, 2023

With the threat posed by drug-resistant pathogenic bacteria, developing non-antibiotic strategies for eradicating clinically prevalent superbugs remains challenging. Ferroptosis is a newly discovered form of regulated cell death that can overcome drug resistance. Emerging evidence shows potential triggering ferroptosis-like antibacterial therapy, but direct delivery iron species inefficient and may cause detrimental effects. Herein, an effective strategy to induce bacterial nonferrous coordinating single-atom metal sites (e.g., Ir Ru) into sp

Language: Английский

Citations

52
Molybdenum-based antimicrobial nanomaterials: A comprehensive review DOI
Jing Liao, Lei Wang, Shuaishuai Ding

et al.

Nano Today, Journal Year: 2023, Volume and Issue: 50, P. 101875 - 101875

Published: May 17, 2023

Language: Английский

Citations

47
Nanomaterial-Based Strategies to Combat Antibiotic Resistance: Mechanisms and Applications DOI Creative Commons
Nargish Parvin, Sang Woo Joo, Tapas Kumar Mandal

et al.

Antibiotics, Journal Year: 2025, Volume and Issue: 14(2), P. 207 - 207

Published: Feb. 18, 2025

The rapid rise of antibiotic resistance has become a global health crisis, necessitating the development innovative strategies to combat multidrug-resistant (MDR) pathogens. Nanomaterials have emerged as promising tools in this fight, offering unique physicochemical properties that enhance efficacy, overcome mechanisms, and provide alternative therapeutic approaches. This review explores diverse nanomaterial-based used resistance, focusing on their mechanisms action practical applications. such metal nanoparticles, carbon-based nanomaterials, polymeric nanostructures exhibit antibacterial through various pathways, including generation reactive oxygen species (ROS), disruption bacterial membranes, enhancement delivery. Additionally, ability nanomaterials bypass traditional biofilm formation efflux pumps, been demonstrated numerous studies. also discusses synergistic effects observed when are combined with conventional antibiotics, leading increased susceptibility reduced required dosages. By highlighting recent advancements clinical applications nanomaterial-antibiotic combinations, paper provides comprehensive overview how reshaping future therapies. Future research directions challenges, toxicity scalability, addressed guide safer, more effective treatments.

Language: Английский

Citations

3
Current Promising Strategies against Antibiotic-Resistant Bacterial Infections DOI Creative Commons
Jin-zhou Ye, Xinhai Chen

Antibiotics, Journal Year: 2022, Volume and Issue: 12(1), P. 67 - 67

Published: Dec. 30, 2022

Infections caused by antibiotic-resistant bacteria (ARB) are one of the major global health challenges our time. In addition to developing new antibiotics combat ARB, sensitizing or pursuing alternatives existing promising options counter antibiotic resistance. This review compiles most anti-ARB strategies currently under development. These include following: (i) discovery novel modification antibiotics, screening small-molecule libraries, exploration peculiar places; (ii) improvement in efficacy through metabolic stimulation loading a novel, more efficient delivery systems; (iii) development conventional such as bacteriophages and their encoded endolysins, anti-biofilm drugs, probiotics, nanomaterials, vaccines, antibody therapies. Clinical preclinical studies show that these treatments possess great potential against ARB. Some products expected become commercially available near future.

Language: Английский

Citations

42
ZnO@ZIF-8 Nanoparticles as Nanocarrier of Ciprofloxacin for Antimicrobial Activity DOI Creative Commons

Bruno Altran Costa,

Marina Paiva Abuçafy, Thúlio Wliandon Lemos Barbosa

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(1), P. 259 - 259

Published: Jan. 11, 2023

Numerous antimicrobial drugs have been prescribed to kill or inhibit the growth of microbes such as bacteria, fungi, and viruses. Despite known therapeutic efficacy these drugs, inefficient delivery could result in an inadequate index several side effects. In order overcome this adversity, present study investigated antibiotic drug loading zeolitic imidazolate frameworks (ZIFs), association with ZnO nanoparticles properties. economic synthesis method, surface was first converted ZIF-8 2-methylimidazole a ligand, resulting ZnO@ZIF-8 structure. This system enables high drug-loading efficiency (46%) drug, ciprofloxacin, within pores ZIF-8. provides control release active moieties, simulated body-fluid conditions, maximum 67% released 96 h. The antibacterial activities CIP-ZnO@ZIF-8 were tested against Gram-positive Staphylococcus aureus strain Gram-negative Pseudomonas aeruginosa strain, showing good inhibition. obtained by combining ciprofloxacin minimal inhibitory concentration (MIC) that 10 times lower than for S. 200 P. aeruginosa, suggesting may potential application prolonged treatment.

Language: Английский

Citations

39
DNA-functionalized carbon quantum dots for electrochemical detection of pyocyanin: A quorum sensing molecule in Pseudomonas aeruginosa DOI

Boobalan Thulasinathan,

D Sujatha,

Sethupathi Murugan

et al.

Biosensors and Bioelectronics, Journal Year: 2023, Volume and Issue: 227, P. 115156 - 115156

Published: Feb. 20, 2023

Language: Английский

Citations

24
Scalable and Versatile Metal Ion Solidificated Alginate Hydrogel for Skin Wound Infection Therapy DOI
Haomiao Zhang,

Ye Lu,

Lei Huang

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(18)

Published: March 14, 2024

Bacterial infections in wounds continue to be a major challenge clinical settings worldwide and represent significant threat human health. This work proposes novel expandable versatile methods for solidifying sodium alginate (SA) with metal ions (such as Fe

Language: Английский

Citations

13
Nanotechnology‐driven strategies to enhance the treatment of drug‐resistant bacterial infections DOI
Junjie Zhang,

Ming Liu,

Haiyang Guo

et al.

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2024, Volume and Issue: 16(3)

Published: May 1, 2024

Abstract The misuse of antibiotics has led to increased bacterial resistance, posing a global public health crisis and seriously endangering lives. Currently, antibiotic therapy remains the most common approach for treating infections, but its effectiveness against multidrug‐resistant bacteria is diminishing due slow development new increase drug resistance. Consequently, developing a\ntimicrobial strategies improving efficacy combat infection become an urgent priority. emergence nanotechnology revolutionized traditional treatment, presenting opportunities refractory infection. Here we comprehensively review research progress in nanotechnology‐based antimicrobial delivery highlight diverse platforms designed target different resistance mechanisms. We also outline use combining with other therapeutic modalities enhance drug‐resistant infections. These innovative have potential susceptibility overcome Finally, challenges prospects application nanomaterial‐based combating are discussed. This article categorized under: Biology‐Inspired Nanomaterials > Nucleic Acid‐Based Structures Therapeutic Approaches Drug Discovery Nanomedicine Infectious Disease

Language: Английский

Citations

13
Powering mesoporous silica nanoparticles into bioactive nanoplatforms for antibacterial therapies: strategies and challenges DOI Creative Commons
Biao Li,

Yan Liao,

Xiaoyu Su

et al.

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Sept. 8, 2023

Abstract Bacterial infection has been a major threat to worldwide human health, in particular with the ever-increasing level of antimicrobial resistance. Given complex microenvironment bacterial infections, conventional use antibiotics typically renders low efficacy control, thus calling for novel strategies effective antibacterial therapies. As an excellent candidate delivery, mesoporous silica nanoparticles (MSNs) demonstrate unique physicochemical advantages Beyond delivery capability, extensive efforts have devoted engineering MSNs be bioactive further synergize therapeutic effect control. In this review, we critically reviewed essential properties that benefit their application, followed by themed summary manipulating into nanoplatforms enhanced The chemically functionalized platform, photo-synergized physical platform and targeting-directed are introduced details, where clinical translation challenges these MSNs-based briefly discussed afterwards. This review provides critical information emerging trend turning bioinert agents, paving way inspire translate nanotherapies combating diseases. Graphical

Language: Английский

Citations

22