Acta Pharmaceutica Sinica B,
Journal Year:
2023,
Volume and Issue:
14(3), P. 1329 - 1344
Published: Oct. 20, 2023
Osteosarcoma
is
usually
resistant
to
immunotherapy
and,
thus
primarily
relies
on
surgical
resection
and
high-dosage
chemotherapy.
Unfortunately,
less
invasive
or
toxic
therapies
such
as
photothermal
therapy
(PTT)
chemodynamic
(CDT)
generally
failed
show
satisfactory
outcomes.
Adequate
multimodal
with
proper
safety
profiles
may
provide
better
solutions
for
osteosarcoma.
Herein,
a
simple
nanocomposite
that
synergistically
combines
CDT,
PTT,
chemotherapy
osteosarcoma
treatment
was
fabricated.
In
this
composite,
small
2D
NiFe-LDH
flakes
were
processed
into
3D
hollow
nanospheres
via
template
methods
encapsulate
5-Fluorouracil
(5-FU)
high
loading
capacity.
The
then
adsorbed
onto
larger
Ti3C2
MXene
monolayers
finally
shielded
by
bovine
serum
albumin
(BSA)
form
5-FU@NiFe-LDH/Ti3C2/BSA
nanoplatforms
(5NiTiB).
Both
in
vitro
vivo
data
demonstrated
the
5-FU
induced
chemotherapy,
driven
effects,
MXene-based
killing
collectively
exhibited
synergistic
"all
one"
anti-tumor
effect.
5NiTiB
improved
tumor
suppression
rate
from
<5%
alone
∼80.1%.
This
nanotherapeutic
platform
achieved
higher
therapeutic
efficacy
lower
agent
dose,
thereby
minimizing
side
effects.
Moreover,
composite
produce,
enabling
fine-tuning
of
dosages
suit
different
requirements.
Thus,
versatile
efficient,
potential
further
development.
Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: July 19, 2023
Abstract
Adjuvants
are
indispensable
components
of
vaccines.
Despite
being
widely
used
in
vaccines,
their
action
mechanisms
not
yet
clear.
With
a
greater
understanding
the
by
which
innate
immune
response
controls
antigen-specific
response,
adjuvants’
beginning
to
be
elucidated.
can
categorized
as
immunostimulants
and
delivery
systems.
Immunostimulants
danger
signal
molecules
that
lead
maturation
activation
antigen-presenting
cells
(APCs)
targeting
Toll-like
receptors
(TLRs)
other
pattern
recognition
(PRRs)
promote
production
antigen
signals
co-stimulatory
signals,
turn
enhance
adaptive
responses.
On
hand,
systems
carrier
materials
facilitate
presentation
prolonging
bioavailability
loaded
antigens,
well
antigens
lymph
nodes
or
APCs.
The
systematically
summarized
at
this
review.
This
is
followed
an
introduction
mechanisms,
properties,
progress
classical
vaccine
adjuvants.
Furthermore,
since
some
adjuvants
under
investigation
exhibit
potency
than
adjuvants,
could
compensate
for
deficiencies
summary
adjuvant
platforms
subsequently
presented.
Notably,
we
highlight
different
immunological
properties
these
platforms,
will
provide
wide
range
options
rational
design
basis,
review
points
out
development
prospects
problems
should
paid
attention
future.
Cancer Discovery,
Journal Year:
2024,
Volume and Issue:
14(11), P. 2089 - 2108
Published: Oct. 23, 2024
Abstract
Antibody–drug
conjugates
(ADC)
represent
one
of
the
most
rapidly
expanding
treatment
modalities
in
oncology,
with
11
ADCs
approved
by
FDA
and
more
than
210
currently
being
tested
clinical
trials.
Spanning
over
40
years,
ADC
development
has
enhanced
our
understanding
multifaceted
mechanisms
action
for
this
class
therapeutics.
In
article,
we
discuss
key
insights
into
toxicity,
efficacy,
stability,
distribution,
fate
ADCs.
Furthermore,
highlight
ongoing
challenges
related
to
their
optimization,
rational
sequencing
strategies,
identification
predictive
biomarkers.
Significance:
The
utilization
have
allowed
relevant
improvements
prognosis
multiple
cancer
types.
Concomitantly,
rise
oncology
produced
several
challenges,
including
prediction
activity,
sequence,
minimization
side
effects,
that
still
too
often
resemble
those
cytotoxic
molecule
they
carry.
review,
retrace
years
field
delve
deep
these
complex
therapeutics
reasons
behind
many
achievements
failures
observed
date.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: June 2, 2024
Abstract
Research
into
mRNA
vaccines
is
advancing
rapidly,
with
proven
efficacy
against
coronavirus
disease
2019
and
promising
therapeutic
potential
a
variety
of
solid
tumors.
Adjuvants,
critical
components
vaccines,
significantly
enhance
vaccine
effectiveness
are
integral
to
numerous
formulations.
However,
the
development
selection
adjuvant
platforms
still
in
their
nascent
stages,
mechanisms
many
adjuvants
remain
poorly
understood.
Additionally,
immunostimulatory
capabilities
certain
novel
drug
delivery
systems
(DDS)
challenge
traditional
definition
adjuvants,
suggesting
that
revision
this
concept
necessary.
This
review
offers
comprehensive
exploration
applications
self-adjuvant
DDS.
It
thoroughly
addresses
existing
issues
mentioned
above
details
three
main
challenges
immune-related
adverse
event,
unclear
mechanisms,
unsatisfactory
outcomes
old
age
group
design
practical
application
cancer
adjuvants.
Ultimately,
proposes
optimization
strategies
which
consists
exploring
adjuvant,
optimizing
DDS,
improving
route
administration
improve
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(5)
Published: Nov. 23, 2023
Abstract
The
immunomodulatory
effect
of
divalent
manganese
cations
(Mn
2+
),
such
as
activation
the
cGAS−STING
pathway
or
NLRP3
inflammasomes,
positions
them
adjuvants
for
cancer
immunotherapy.
In
this
study,
it
is
found
that
trace
Mn
ions,
bound
to
bovine
serum
albumin
(BSA)
form
Mn@BSA
nanocomplexes,
stimulate
pro‐inflammatory
responses
in
human‐
murine‐derived
macrophages
through
TLR4‐mediated
signaling
cascades.
Building
on
this,
assembly
nanocomplexes
obtain
nanowire
structures
enables
stronger
and
longer‐lasting
immunostimulation
by
regulating
phagocytosis.
Furthermore,
their
nanowires
efficiently
activate
peritoneal
macrophages,
reprogramme
tumor‐associated
inhibit
growth
melanoma
tumors
vivo.
They
also
show
better
biosafety
potential
clinical
applications
compared
typical
TLR4
agonists
lipopolysaccharides.
Accordingly,
findings
provide
insights
into
mechanism
metalloalbumin
complexes
TLR
macrophage
polarization
highlight
importance
nanostructures
macrophage‐mediated
innate
immunity.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(29)
Published: April 28, 2023
Tumor-draining
lymph
nodes
(TDLNs)
are
the
first
sites
where
tumor
components
reach
and
dendritic
cells
(DCs)
present
tumor-associated
antigens
to
T
cells.
DCs
rely
on
autophagy
process
into
epitope
peptides
form
epitope-MHC
complexes.
Selective
delivery
of
autophagy-stimulating
drugs
TDLNs
may
be
a
precise
strategy
boost
chemotherapy-induced
antitumor
immunity.
Here,
multistage
stimulating
is
proposed
activate
immunity
cascade
by
inducing
immunogenic
death
elevating
antigen
presentation
in
TDLNs.
A
tumor-microenvironment-responsive
"albumin-hitchhiking"
micelle
established
self-assembling
tumor-targeting
oxaliplatin
prodrug
lipophilized
trehalose
prodrug.
This
demonstrates
that
lipophilic
modification
with
DSPE
tail
exposure
site
enhances
its
binding
endogenous
albumin
realizes
TDLNs-selective
reflux,
it
upregulates
processing
DCs.
study
introduces
an
approach
for
targeted
provides
insights
mechanisms
tumor-specific
