ACS Applied Nano Materials,
Journal Year:
2024,
Volume and Issue:
7(20), P. 23397 - 23415
Published: Oct. 12, 2024
Hydrogen
sulfide
(H2S)
is
recognized
as
the
third
gaseous
signaling
molecule
present,
playing
a
crucial
role
in
cellular
processes.
When
designing
nanomaterials,
H2S
not
only
serves
cancer
biomarker
but
also
directly
influences
tumor
cell
proliferation
and
metastasis
by
modulating
its
concentration.
However,
gas
donor
inability
to
actively
accumulate
within
tumors
release
controlled
manner
results
restricted
treatment
efficacy
potential
toxic
side
effects.
Near-infrared
(NIR)
responsive
photothermal
probes
are
characterized
their
rapid
response
time,
high
selectivity,
sensitivity,
noninvasive
attributes.
They
offer
opportunity
for
precise,
real-time,
modulation
of
concentrations
at
both
murine
levels.
The
integration
therapy
with
other
modalities
through
multifunctional
nanocarrier
platforms
shows
promise
enhancing
outcomes
while
minimizing
adverse
development
capable
controllably
properties
considered
essential
yet
challenging
academic
research.
This
Review
critically
assesses
two
primary
approaches
NIR
strategies
involving
H2S:
targeted
utilizing
combining
alternative
modalities.
Additionally,
this
addresses
current
limitations
these
technologies
outlines
future
directions
advancement.
Overall,
aims
provide
insights
guidance
seamless
therapy,
aligning
rigorous
standards
journals.
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(2), P. 244 - 244
Published: Feb. 12, 2025
Photodynamic
therapy
has
established
itself
as
a
clinical
treatment
for
certain
superficial
cancers
by
converting
oxygen
into
cytotoxic
singlet
to
eradicate
cancer
cells.
Porphyrin-based
nanoscale
metal-organic
frameworks
have
emerged
promising
photosensitive
platforms
due
their
ability
prevent
the
hydrophobic
aggregation
quenching
of
porphyrin
molecules
and
enhance
accumulation
at
tumor
site,
thereby
becoming
focal
point
in
photodynamic
materials
research.
However,
elevated
levels
glutathione
other
reductive
substances
within
cells
can
alleviate
oxidative
stress
induced
from
process,
thus
protecting
intracellular
biomolecular
structures
damage.
Consequently,
it
is
crucial
design
functionalized
nanoplatforms
that
integrate
depletion
with
porphyrin-based
significantly
boost
efficacy.
Moreover,
excess
disrupt
structure
frameworks,
which
not
only
increases
capacity
generate
upon
light
exposure
but
also
aids
recovery
fluorescence
imaging
capabilities.
Additionally,
this
specificity
minimizes
photosensitizing
harm
normal
tissues.
This
review
compiles
recent
advancements
developing
enhanced
phototherapy
through
depletion.
It
aims
promote
further
application
provide
valuable
insights
preclinical
applications.
By
highlighting
strategies
improve
therapeutic
outcomes
while
maintaining
safety
profiles,
summary
seeks
advance
development
more
effective
targeted
treatments.
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 21, 2025
Photothermal
therapy
(PTT)
is
emerging
as
a
promising
cancer
treatment,
but
uneven
heat
distribution
increases
side
effects
and
reduces
treatment
precision,
where
high-temperature
zones
risk
inducing
undesired
inflammation,
while
low-temperature
regions
are
insufficient
due
to
upregulation
of
shock
proteins
(HSPs).
Herein,
gas-assisted
PTT
strategy
designed
link
near-infrared
heptamethine
cyanine
(Cy7)
with
self-immolative
phenyl
thiocarbonate
(PTC),
hydrogen
sulfide
(H2S)
donor
through
disulfide
bond,
creating
small-molecule
photosensitizer
(Cy7-SS-PTC)
that
can
self-assemble
into
nanoparticles
(NPs)
without
stabilizers.
Upon
internalized
by
cells,
Cy7-SS-PTC
NPs
respond
elevated
glutathione
levels,
simultaneously
release
Cy7
H2S
via
cascade
reaction.
The
released
reassembles
nanoaggregates,
generating
hyperthermia
under
808
nm
light
irradiation,
then
binds
albumin,
producing
strong
fluorescence
track
tumors
for
precise
treatment.
not
only
disrupts
the
mitochondrial
respiratory
chain,
blocks
ATP
production,
suppresses
HSP70
overexpression
amplify
efficacy
also
curbs
proinflammatory
cytokines
in
zones,
delivering
powerful
tumor
ablation
minimal
inflammation.
This
small-molecule-based
"H2S-assisted
PTT"
optimizes
current
validates
its
potential
clinical
application.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 23, 2025
Abstract
Photodynamic
therapy
(PDT)
and
photothermal
(PTT)
offer
the
advantages
of
precise
temporal
spatial
selectivity
in
cancer
treatment,
minimizing
damage
to
normal
cells
while
effectively
eliminating
tumor
cells.
However,
therapeutic
efficacy
phototherapy
is
always
hindered
by
challenges
such
as
hypoxia
heat
resistance.
Herein,
a
pH‐responsive
metal‐drug
nanocomplex
(denoted
PAFH)
comprising
hypericin
(HYP),
apigenin
(APG),
polyvinylpyrrolidone
(PVP),
Fe
3+
developed
enhance
PDT
PTT.
The
PAFH
exhibits
properties
under
808
nm
laser
irradiation,
which
can
disassociate
response
acidic
microenvironment
temperature
increase
induced
PTT,
thereby
eventually
triggering
on‐site
release
APG
HYP.
released
inhibits
synthesis
shock
protein
HSP‐90,
facilitating
PAFH‐mediated
PTT
kill
at
mild
temperature.
Additionally,
alleviates
then
regulates
expression
hypoxia‐inducible
factor
HIF‐1𝛼,
increasing
cellular
oxygen
levels
produce
singlet
for
enhanced
HYP‐mediated
inhibiting
metastasis.
Ultimately,
this
sophisticated
nanosystem
represents
an
advanced
strategy
promote
mitigating
counteracting
resistance,
significantly
improving
therapy.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Nov. 4, 2024
Gas
therapy
has
emerged
as
a
promising
approach
for
treating
cancer,
with
gases
like
NO,
H2S,
and
CO
showing
positive
effects.
Among
these,
NO
is
considered
key
gas
molecule
significant
potential
in
stopping
cancer
progression.
However,
due
to
its
high
reactivity
short
half-life,
delivering
directly
tumors
crucial
enhancing
treatment.
NO-driven
nanomedicines
(NONs)
have
been
developed
effectively
deliver
donors
tumors,
great
progress
recent
years.
This
review
provides
an
overview
of
the
latest
advancements
NO-based
nanotherapeutics.
It
discusses
types
used
current
research,
mechanisms
action
behind
different
delivery
systems
also
explores
combining
other
treatments
enhanced
therapy.
Finally,
it
examines
future
prospects
challenges
using
NONs
clinical
settings
Molecules,
Journal Year:
2023,
Volume and Issue:
28(16), P. 6038 - 6038
Published: Aug. 13, 2023
Phototherapy
has
the
advantages
of
being
a
highly
targeted,
less
toxic,
invasive,
and
repeatable
treatment,
compared
with
conventional
treatment
methods
such
as
surgery,
chemotherapy,
radiotherapy.
The
preparation
strategies
are
significant
in
order
to
determine
physical
chemical
properties
nanoparticles.
However,
choosing
appropriate
meet
applications
is
still
challenging.
This
review
summarizes
recent
progress
organic
nanoparticles,
mainly
focusing
on
principles,
methods,
nanopreparation
strategies.
In
addition,
typical
examples
cancer
phototherapeutics
introduced
detail
inform
choice
relative
future
trend
outlook
preliminarily
proposed.
