ACS Applied Nano Materials,
Journal Year:
2024,
Volume and Issue:
7(10), P. 12129 - 12141
Published: May 7, 2024
The
poor
targeting
and
high
toxicity
of
chemotherapeutic
drugs
make
them
less
effective
against
breast
cancer.
In
this
study,
in
accordance
with
their
photothermal
effect,
the
aptamer
(Apt)
(AS1411)
doxorubicin
(DOX)
were
linked
to
zeolite
imidazole
salt
frame8
(ZIF-8)
by
using
gold
nanorods
(Au
NRs).
Thereby,
a
multifunctional
nanoparticle
platform
(DOX/Au-Apt@ZIF-8)
was
constructed
deliver
effectively
utilize
DOX
realize
antitumor
effects
multimodal
combination
chemotherapy–target–photothermal
therapy.
This
responsive
both
pH
near-infrared
(NIR)
light.
characterization
experiments,
DOX/Au-Apt@ZIF-8
exhibited
good
dispersibility,
particle
size
stability,
consistent
spectral
characteristics.
conversion
efficiency
up
53.5%.
cell
uptake
cycle
targeted
tumor
cells
blocked
growth
S
phase.
Moreover,
an
vivo
exerted
inhibitory
on
tumors.
When
combined
NIR
irradiation,
inhibited
tissue
enhancing
inducing
apoptosis.
Importantly,
histopathological
analysis
revealed
that
nanoparticles
toxic
other
organs
had
biosafety.
As
such,
fabricated
study
is
expected
offer
treatment
approach
Clinical and Translational Medicine,
Journal Year:
2025,
Volume and Issue:
15(4)
Published: April 1, 2025
Abstract
Angiogenesis,
as
a
core
marker
of
cancer
survival
and
growth,
is
integral
to
the
processes
tumour
invasion
metastasis.
In
recent
years,
targeted
angiogenesis
treatment
strategies
have
gradually
become
an
important
direction
in
treatment.
Single‐cell
sequencing
technology
can
provide
new
insights
into
by
providing
deeper
understanding
heterogeneity
endothelial
cells
exploring
interactions
between
surrounding
microenvironment.
Here,
we
systematically
review
research
progress
cell
pathophysiology
its
endothelial‒mesenchymal
transition
illustrate
from
single‐cell
perspective.
Finally,
examine
contributions
different
types
within
microenvironment
relation
angiogenesis,
well
latest
therapy,
hoping
useful
clinical
application
antiangiogenic
Furthermore,
summary
present
development
potential
inhibitors
ongoing
trials
for
combination
therapies
provided.
Key
points
Angiogenesis
plays
key
role
progression,
metastasis,
so
targeting
are
becoming
therapy.
Interactions
stromal
immune
significant
angiogenesis.
The
immunotherapy
nanotechnology
therapy
provides
vital
strategy
prolonging
patients.
ACS Applied Nano Materials,
Journal Year:
2024,
Volume and Issue:
7(10), P. 12129 - 12141
Published: May 7, 2024
The
poor
targeting
and
high
toxicity
of
chemotherapeutic
drugs
make
them
less
effective
against
breast
cancer.
In
this
study,
in
accordance
with
their
photothermal
effect,
the
aptamer
(Apt)
(AS1411)
doxorubicin
(DOX)
were
linked
to
zeolite
imidazole
salt
frame8
(ZIF-8)
by
using
gold
nanorods
(Au
NRs).
Thereby,
a
multifunctional
nanoparticle
platform
(DOX/Au-Apt@ZIF-8)
was
constructed
deliver
effectively
utilize
DOX
realize
antitumor
effects
multimodal
combination
chemotherapy–target–photothermal
therapy.
This
responsive
both
pH
near-infrared
(NIR)
light.
characterization
experiments,
DOX/Au-Apt@ZIF-8
exhibited
good
dispersibility,
particle
size
stability,
consistent
spectral
characteristics.
conversion
efficiency
up
53.5%.
cell
uptake
cycle
targeted
tumor
cells
blocked
growth
S
phase.
Moreover,
an
vivo
exerted
inhibitory
on
tumors.
When
combined
NIR
irradiation,
inhibited
tissue
enhancing
inducing
apoptosis.
Importantly,
histopathological
analysis
revealed
that
nanoparticles
toxic
other
organs
had
biosafety.
As
such,
fabricated
study
is
expected
offer
treatment
approach
