Emerging nitric oxide gas‐assisted cancer photothermal treatment

Exploration, Journal Year: 2024, Volume and Issue: 4(6)

Published: March 24, 2024

Abstract Photothermal therapy (PTT) has garnered significant attention in recent years, but the standalone application of PTT still faces limitations that hinder its ability to achieve optimal therapeutic outcomes. Nitric oxide (NO), being one most extensively studied gaseous molecules, presents itself as a promising complementary candidate for PTT. In response, various nanosystems have been developed enable simultaneous utilization and NO‐mediated gas (GT), with integration photothermal agents (PTAs) thermally‐sensitive NO donors prevailing approach. This combination seeks leverage synergistic effects GT while mitigating potential risks associated toxicity through use single laser irradiation. Furthermore, additional internal or external stimuli employed trigger release when combined different types PTAs, thereby further enhancing efficacy. comprehensive review aims summarize advancements gas‐assisted cancer treatment. It commences by providing an overview precursors, including those sensitive photothermal, light, ultrasound, reactive oxygen species, glutathione. These precursors are discussed context dual‐modal PTT/GT. Subsequently, incorporation other treatment modalities such chemotherapy (CHT), photodynamic (PDT), alkyl radical therapy, radiation immunotherapy (IT) creation triple‐modal nanoplatforms is presented. The explores tetra‐modal therapies, PTT/GT/CHT/PDT, PTT/GT/CHT/chemodynamic (CDT), PTT/GT/PDT/IT, PTT/GT/starvation (ST)/IT, PTT/GT/Ca 2+ overload/IT, PTT/GT/ferroptosis (FT)/IT, PTT/GT/CDT/IT. Finally, challenges future perspectives concerning these novel paradigms discussed. anticipated serve valuable resource studies focused on development innovative photothermal/NO‐based nanotheranostics.

Language: Английский

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Multifunctional metal-organic frameworks with photothermal-triggered nitric oxide release for gas/photothermal synergistic cancer therapy

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 684, P. 47 - 59

Published: Jan. 4, 2025

Language: Английский

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New Advances in Periodontal Functional Materials Based on Antibacterial, Anti‐Inflammatory, and Tissue Regeneration Strategies

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 2, 2025

With the global population aging, awareness of oral health is rising. Periodontitis, a widespread bacterial infectious disease, gaining attention. Current novel biomaterials address key clinical issues like infection, gum inflammation, tooth loosening, and loss, focusing on antibacterial, anti-inflammatory, tissue regeneration properties. However, strategies that integrate advantages these to achieve synergistic therapeutic effects by clearing biofilms, inhibiting inflammation activation, restoring periodontal soft hard functions remain very limited. Recent studies highlight link between periodontitis systemic diseases, underscoring complexity disease. There an urgent need find comprehensive treatment plans requirements. Whether integrating new enhance existing treatments or developing approaches replace traditional therapies, efforts will drive advancements in treatment. Therefore, this review compares with treatments. It highlights design concepts mechanisms functional materials, their properties, discusses importance strategies. This aims provide guidance for emerging research promote development precise efficient

Language: Английский

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Hydroxypropyl trimethyl ammonium chloride chitosan (HACC)-modified protein nanoparticles enhance docetaxel oral delivery and exhibit potent in vitro anti-tumor and macrophage-activating effects

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 305, P. 141375 - 141375

Published: Feb. 21, 2025

Language: Английский

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Nitric Oxide‐Based Nanomedicines for Conquering TME Fortress: Say “NO” to Insufficient Tumor Treatment

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(13)

Published: Dec. 21, 2023

Abstract Almost all cancer treatments are significantly limited by the strong tumor microenvironment (TME) fortress formed abnormal vasculature, dense extracellular matrix (ECM), multidrug resistance (MDR) system, and immune “cold” environment. In huge efforts of dismantling TME fortress, nitric oxide (NO)‐based nanomedicines increasingly occupying a central position have already been identified as super “strong polygonal warriors” to dismantle for efficient treatment, benefiting from NO's unique physicochemical properties extremely fascinating biological effects. However, there is paucity systematic review elaborate on progress fundamental mechanism NO‐based in oncology this aspect. Herein, key characteristics potential NO reprogramming delineated highlighted. The evolution donors advantages discussed subsequently. Moreover, latest solid tumors comprehensively reviewed, including normalizing overcoming ECM barrier, reversing MDR, reactivating immunosuppression TME. Lastly, prospects, limitations, future directions manipulation provide new insights into construction more applicable anticancer nanomedicines.

Language: Английский

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Photothermal-controlled NO-releasing Nanogels reverse epithelial-mesenchymal transition and restore immune surveillance against cancer metastasis

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 371, P. 16 - 28

Published: May 22, 2024

Language: Английский

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Micro/nano system-mediated local treatment in conjunction with immune checkpoint inhibitor against advanced-Stage malignant melanoma

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 497, P. 154499 - 154499

Published: Aug. 3, 2024

Language: Английский

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Potential therapeutic applications of medical gases in cancer treatment

Medical Gas Research, Journal Year: 2025, Volume and Issue: 15(2), P. 309 - 317

Published: Jan. 18, 2025

Medical gases were primarily used for respiratory therapy and anesthesia, which showed promising potential in the cancer therapy. Several physiological pathological processes affected by key gases, such as oxygen, carbon dioxide, nitric oxide, hydrogen sulfide, monoxide. Oxygen targets shrinking tumor via hyperbaric oxygen therapy, once combined with radiation it enhances its effect. Nitric oxide has both anti- pro-tumor effects depending on level; at high doses, triggers cell death while low doses supports growth. The same concept is applied to sulfide promotes growth enhancing mitochondrial bioenergetics supporting angiogenesis concentrations, concentrations induces sparing normal cells. Furthermore, dioxide helps induce apoptosis improve oxygenation treatments increasing release of from hemoglobin. Moreover, high-dose monoxide gas demonstrated significant reductions vivo supported nanomedicine specialized medicines boost delivery cells availability peroxide. Despite potentials these several challenges remain. Gas should be regulated balance anti-tumor sulfide. effective systems, nanoparticles, developed targeted

Language: Английский

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Tumor-targeted near-infrared/ultraviolet-triggered photothermal/gas therapy nanoplatform for effective cancer synergistic therapy

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 249, P. 114530 - 114530

Published: Jan. 20, 2025

Language: Английский

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C3N4 nanosheet: sonopiezoelectric effect to boost NO therapy

Carbon, Journal Year: 2025, Volume and Issue: unknown, P. 120330 - 120330

Published: April 1, 2025

Language: Английский

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