Janus Nanofiber Membranes with Photothermal‐Enhanced Biofluid Drainage and Sterilization for Diabetic Wounds

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(24)

Published: Feb. 16, 2024

Abstract Diabetic wounds are difficult to heal, and the key wound healing is exudate management effective disinfection. Inspired by asymmetric wettability of Janus‐structured lotus leaves, herein study has presented design a biomimetic Janus membrane that integrates unidirectional biofluid drainage photothermal‐enhanced evaporation/sterilization capabilities for accelerating diabetic healing. This prepared electrospinning polyacrylonitrile (PAN) nanofiber containing polydopamine (PDA) on surface polypropylene (PP) nonwoven membrane. Such PP/PAN x%PDA enables antigravity “pumping” water from hydrophobic PP layer hydrophilic PAN within 22 s through contact points interface. The incorporation 30 wt% PDA in imparts high photoabsorption photothermal responsiveness, facilitating continuous volatilization exudate, achieving twice displacement water, causing irreversible damage bacteria. As result, it effectively alleviates inflammation cellular fibrosis while promoting collagen deposition due its structure antibacterial properties. Impressively, such achieves an impressive closure rate 96.7% wounds, better than (59.8%) conventional bandages. Therefore, this offers promising alternative chronic wounds.

Language: Английский

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Chitosan-based injectable hydrogel with multifunction for wound healing: A critical review

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 333, P. 121952 - 121952

Published: Feb. 19, 2024

Language: Английский

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Progress in nanomaterial-based synergistic photothermal-enhanced chemodynamic therapy in combating bacterial infections

Progress in Materials Science, Journal Year: 2024, Volume and Issue: 144, P. 101292 - 101292

Published: April 6, 2024

The prevalence of multidrug-resistant (MDR) bacterial infections has emerged as a serious threat to clinical treatment and global human health, become one the most important challenges in therapy. Hence, there is an urgent need develop safe, effective, new antibacterial strategies based on multifunctional nanomaterials for accurate detection MDR infections. Chemodynamic therapy (CDT) emerging therapeutic strategy that uses Fenton/Fenton-like metal-based nanocatalysts convert hydrogen peroxide (H2O2) into hydroxyl radicals (OH) destroy Despite enormous potential CDT, single CDT limitations such low catalytic efficacy insufficient production H2O2. In this regard, can be combined with other strategies, photothermal (PTT), which effectively enhanced by PTT heating effect. Thus, rational combination nanoplatform been demonstrated highly efficient achieving better This review summarizes discusses latest advances photothermal-enhanced (PT/CDT) infection theranostics well advantages, challenges, future research directions applications, will inspire development PT/CDT

Language: Английский

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Green and sustainable hydrogels based on Quaternized chitosan to enhance wound healing

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 492, P. 152288 - 152288

Published: May 20, 2024

Language: Английский

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Recent advances of hydrogels as smart dressings for diabetic wounds

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(5), P. 1126 - 1148

Published: Jan. 1, 2024

This review highlights the latest progress of smart hydrogel dressings for bandaging, monitoring and therapy diabetic wounds.

Language: Английский

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Research progress of natural polysaccharide-based and natural protein-based hydrogels for bacteria-infected wound healing

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 496, P. 153803 - 153803

Published: July 6, 2024

Language: Английский

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Multifunctional dynamic chitosan-guar gum nanocomposite hydrogels in infection and diabetic wound healing

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: unknown, P. 123316 - 123316

Published: Jan. 1, 2025

Language: Английский

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Healing with precision: A multi-functional hydrogel-bioactive glass dressing boosts infected wound recovery and enhances neurogenesis in the wound bed

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 370, P. 210 - 229

Published: April 27, 2024

Language: Английский

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Copper-based nanomaterials for the treatment of bacteria-infected wounds: material classification, strategies and mechanisms

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 522, P. 216205 - 216205

Published: Sept. 11, 2024

Language: Английский

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Integrated Copper Nanomaterials‐Decorated Microsphere Photothermal Platform for Comprehensive Melanoma Treatment

Small Structures, Journal Year: 2024, Volume and Issue: 5(6)

Published: April 1, 2024

Patients who undergo resection for melanoma face challenges, such as delayed healing and radiation dermatitis. Moreover, incomplete tumor is a key factor contributing to poor prognosis increased recurrence rates. However, therapeutic platform that can effectively prevent promote wound remains challenge. Hence, pioneering approach presented using melanoma‐derived cancer cell membrane (CM) antigen encapsulate copper (Cu)‐based metal‐organic framework (MOF) nanomaterials fabricate termed MOF@CM. Then MOF@CM adsorbed onto polydopamine (PDA)‐modified poly lactic‐co‐glycolic acid (PLGA) porous microspheres (PLGA/PDA) develop the nanomaterials‐decorated PLGA/PDA‐CCM (PLGA/PDA loaded with CM‐coated MOF). It exerts homologous targeting photothermal effects, inducing immunogenic death. Simultaneously, sustained release of shows enhanced presentation in dendritic cells (DCs) help CpG, induces DC maturation activated immune responses, acting an effective vaccine recurrence. The harnesses combined advantages local thermal effect presence Cu‐based MOF, which endow antibacterial properties stimulate angiogenesis, thereby facilitating mitigating This integrated microsphere treatment represents promising strategy addressing melanoma.

Language: Английский

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